Understanding attention-control across functional systems and temporal scales

了解跨功能系统和时间尺度的注意力控制

• 批准号: 8485686
• 负责人: Mark Steven Cohen
• 金额: $ 22.18万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-11 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8485686
• 关键词: Addictive Behavior; Aging; Arousal; Attention; Attention Deficit Disorder; Bipolar Disorder; Books; Brain; Classification; Coupled; Coupling; Crowding; Decision Making; Diagnosis; Disease; Electroencephalography; Evolution; Failure; Functional Magnetic Resonance Imaging; Image; Impairment; Individual; Investigation; Measures; Mental Depression; Methods; Mind; Modeling; Monitor; Obsessive-Compulsive Disorder; Parietal; Participant; Pattern; Performance; Play; Process; Reading; Research; Rest; Role; Sampling; Schizophrenia; Signal Transduction; Source; Specificity; Stimulus; System; Testing; Thalamic structure; Time; Treatment Efficacy; Vision; behavioral impairment; brain metabolism; cognitive control; design; distraction; experience; falls; forgetting; improved; interest; millisecond; neuromechanism; neuropsychiatry; novel; relating to nervous system; response; sensory stimulus; stem; time use

DESCRIPTION (provided by applicant): Nearly every neuropsychiatric disorder (e.g., depression & schizophrenia, attention deficit disorder, obsessive compulsive disorder and bipolar disorder) shows deficits in attention control: the ability to attend to behaviorally relevat sensory stimuli and ignore irrelevant stimuli. Attentional control is, of course, a central factor n the attention deficit disorders and is thought to play a significant role in addictive behaviors. These deficits can occur because of impaired suppression of distractions or because of fluctuations in sustaining of attention, when the mind wanders. We propose to develop measures that will allows us to distinguish between these deficits at the neural level, describe their interactions and facilitate tracking of attention performance that is imperative for accurate diagnosis and monitoring of treatment efficacy. To achieve this we will combine the complementary methods of electroencephalography (EEG) (especially relevant to short term processes and spectral specificity) and functional MRI (relevant to slow evolutions in sustained attention and providing spatial specificity not readily observed with EEG) to measure fast and slow changes in attention. These measures will ultimately allow us to explain when and why internal state and distractibility impair behavior.

描述（由申请人提供）：几乎每种神经精神疾病（例如抑郁症和精神分裂症，注意力缺陷障碍，强迫症和双相情感障碍）都显示出注意力控制中的缺陷：能够参加行为相关的感觉刺激并忽略无关紧要的刺激。当然，注意力控制是注意力不足障碍的核心因素，被认为在成瘾行为中起着重要作用。这些缺陷可能是由于抑制分心的抑制受损或在思维徘徊时的注意力下降而发生的。我们建议制定措施，使我们能够在神经层面区分这些缺陷，描述它们的相互作用并促进关注表现的​​跟踪，这对于准确而言至关重要 诊断和监测治疗功效。为了实现这一目标，我们将结合脑电图（EEG）（尤其与短期过程和光谱特异性）的互补方法和功能MRI（与持续注意的缓慢发展相关，并提供空间特异性，而不是与EEG相关的空间特异性），以衡量注意力的快速变化和慢速变化。这些措施最终将使我们能够解释内部状态何时以及为什么会损害行为。