Reducing Depressive Symptoms in Systemic Lupus Erythematosus

减少系统性红斑狼疮的抑郁症状

基本信息

批准号：
8074981
负责人：
CAROL MARIE GRECO
金额：
$ 32.4万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-01 至 2014-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8074981
关键词：
Accounting Address Adult Affect African American Aftercare Anguish Antigens Area Arthralgia Attention Attenuated Autoimmune Diseases Behavior Behavior Therapy Binding Biological Markers Biomedical Research Caucasians Caucasoid Race Cells Chronic Chronic Disease Cognitive Therapy Complement Activation Complex Control Groups Counseling Depressive disorder Disease Distress Dose Educational Intervention Endogenous depression Epidemiologic Studies Equipment and supply inventories Etiology Evaluation Fatigue Female Flare Future General Population Great Britain Guided imagery Health Healthcare Hospitalization Immune Immune response Incidence Inflammation Inflammatory Intervention Investigation Lead Lupus Major Depressive Disorder Measures Mediator of activation protein Medical Mental Depression Mental Health Mind-Body Intervention Mind-Body Method Musculoskeletal Diseases Myalgia National Institute of Arthritis and Musculoskeletal and Skin Diseases Organ Outcome Outcome Measure Pain Participant Patients Pharmaceutical Preparations Pilot Projects Population Publishing Randomized Randomized Controlled Trials Relapse Relaxation Research Rheumatism Sampling Self Care Self Efficacy Self Management Serum Severities Site Socioeconomic Status Stress Symptoms Systemic Lupus Erythematosus Testing Therapeutic Time Training Training Programs Translating Woman Work activation product biopsychosocial body-mind burden of illness complement C4d coping depressive symptoms design disability disability-adjusted life years emotion regulation follow-up health related quality of life immune activation immune function improved indexing innovation inventory of depressive symptomatology low socioeconomic status mindfulness novel novel strategies physical conditioning primary outcome psychologic psychological distress single episode major depressive disorder skills skills training skin disorder success therapy design

项目摘要

DESCRIPTION (provided by applicant): Systemic lupus erythematosus (SLE) is a chronic, multisystemic inflammatory disease that is frequently associated with significant psychological suffering. Building upon our team's strengths in lupus biomedical research and behavioral interventions, we propose to study a non-pharmacologic intervention to improve mental and physical health of patients with SLE and co-morbid depression. In this project, entitled, Reducing Depressive Symptoms in SLE, we will investigate the efficacy of an innovative non-pharmacologic intervention, Mind-Body Skills Training (MBST) for improving mental and physical health outcomes in SLE in a randomized controlled trial (RCT). MBST is a novel approach that combines cognitive-behavioral therapy methods, mind-body relaxation skills, and mindfulness components, each of which is beneficial for reducing pain and/or distress in other inflammatory conditions. We will assign 150 SLE patients with depressive disorder or subsyndromal depression to MBST or to a supportive counseling control condition. The primary specific aims of the project are to evaluate the effects of the 8-session MBST program on 1) mental health (depression) and 2) physical health (pain, fatigue, and health-related quality of life). Additionally we will explore the effects of the MBST intervention on 1) novel SLE biomarkers of inflammation and immune function: cell-bound complement activation products, developed at our site, 2) measures of SLE disease activity, and we will explore 3) potential treatment modifiers and mediators: baseline pain and socioeconomic status, and self-efficacy and perceived stress. We will evaluate health outcomes after the interventions and at 6- and 12-months follow-up. SLE is one of the most complex autoimmune diseases, with one of the highest rates of depression. The MBST intervention has strong potential for addressing the unique physical manifestations and mental suffering in this patient group, and may have broad impact on distressed patients with other debilitating chronic diseases. PUBLIC HEALTH RELEVANCE: Depressive disorders are very common in patients with chronic inflammatory diseases, including Systemic Lupus Erythematosus (SLE). We will evaluate the effects of a novel non-pharmacologic intervention, Mind- Body Skills Training (MBST), for improving mental and physical health in SLE patients with comorbid depression. If MBST is beneficial for SLE, which is one of the most complex and devastating autoimmune diseases, the intervention may have broad health impact on patients suffering from other debilitating chronic illnesses as well.

描述（由申请人提供）：系统性红斑狼疮（SLE）是一种慢性、多系统炎症性疾病，通常与严重的心理痛苦相关。基于我们团队在狼疮生物医学研究和行为干预方面的优势，我们建议研究一种非药物干预措施，以改善系统性红斑狼疮和共病抑郁症患者的心理和身体健康。在这个题为“减少 SLE 抑郁症状”的项目中，我们将在一项随机对照试验 (RCT) 中研究创新的非药物干预措施——身心技能训练 (MBST) 对于改善 SLE 心理和身体健康结果的功效。 MBST 是一种新颖的方法，结合了认知行为治疗方法、身心放松技巧和正念成分，每一种方法都有益于减轻其他炎症条件下的疼痛和/或痛苦。我们将 150 名患有抑郁症或亚综合征抑郁症的 SLE 患者分配到 MBST 或支持性咨询控制条件下。该项目的主要具体目标是评估 8 期 MBST 计划对 1) 心理健康（抑郁）和 2) 身体健康（疼痛、疲劳和健康相关生活质量）的影响。此外，我们将探讨 MBST 干预对 1) 炎症和免疫功能的新型 SLE 生物标志物的影响：我们现场开发的细胞结合补体激活产品，2) SLE 疾病活动的测量，我们将探索 3) 潜在的治疗方法调节因素和调节因素：基线疼痛和社会经济地位、自我效能和感知压力。我们将在干预后以及 6 个月和 12 个月的随访时评估健康结果。系统性红斑狼疮是最复杂的自身免疫性疾病之一，也是抑郁症发病率最高的疾病之一。 MBST 干预对于解决该患者群体独特的身体表现和精神痛苦具有巨大的潜力，并且可能对患有其他使人衰弱的慢性疾病的痛苦患者产生广泛的影响。公共卫生相关性：抑郁症在慢性炎症性疾病患者中非常常见，包括系统性红斑狼疮 (SLE)。我们将评估一种新型非药物干预措施——身心技能训练（MBST）对于改善患有抑郁症的 SLE 患者的心理和身体健康的效果。如果 MBST 对 SLE（最复杂和最具破坏性的自身免疫性疾病之一）有益，那么该干预措施也可能对患有其他使人衰弱的慢性疾病的患者产生广泛的健康影响。