OC Foundation Genetics Collaborative Conference

OC基金会遗传学合作会议

• 批准号: 8514062
• 负责人: DAVID L PAULS
• 金额: $ 4.73万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-23 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8514062
• 关键词: Adult; Affect; Architecture; Attention deficit hyperactivity disorder; Autistic Disorder; Bipolar Disorder; Child; Collaborations; Complex; Country; Detection; Disease; Family; Foundations; Funding; Genes; Genetic; Gilles de la Tourette syndrome; Goals; Grant; Group Meetings; Individual; Mental disorders; Molecular Genetics; National Institute of Mental Health; Obsessive-Compulsive Disorder; Parents; Play; Publishing; Research; Research Personnel; Role; Sample Size; Sampling; Schizophrenia; Site; Susceptibility Gene; Text; Time; Triad Acrylic Resin; Twin Multiple Birth; United States; genetic linkage; genome wide association study; meetings; symposium; working group

ABSTRACT This is a competing renewal of a multi-year conference grant that has supported a forum for researchers to pursue collaborative studies of the molecular genetics of obsessive compulsive disorder (OCD). This application is consistent with NIMH initiatives to facilitate meetings in which researchers come together to establish mechanisms for collaborating in a manner that would facilitate the detection of genes predisposing to psychiatric disorders. At the present time, there are approximately 60 researchers who have attended the meetings of this group. These individuals come from 38 different research centers in 13 foreign countries and the United States. OCD is a serious psychiatric condition that can have debilitating affects on both adults and children. The importance of genetic factors in OCD has been demonstrated by twin and family aggregation studies. Furthermore, recent molecular genetic studies have begun to provide evidence that specific genes may play a role in the manifestation of the disorder. Although these preliminary results are encouraging, several considerations suggest that fully clarifying the genetic architecture of OCD will require large samples and collaborative efforts. It is clear from ongoing studies of the genetics of schizophrenia, autism, Gilles de la Tourette's syndrome, ADHD and bipolar disorder that are consistent with statistical considerations regarding the power to locate genes for complex disorders, that samples collected by individual investigators may not be sufficiently large to provide significant evidence for genetic linkage. Furthermore, once linkage has been demonstrated, even larger samples sizes are needed to identify and characterize susceptibility genes. Thus, it is clear that coordinated collaboration is needed to share findings and pool samples. Cooperative research of this type is often difficult. With the support of the Obsessive Compulsive Foundation and this grant from NIMH, this group of investigators is collaborating on the first Genome Wide Association Study of OCD. At the present time, investigators from 19 different sites have agreed to combine their OCD samples. The total sample consists of approximately 4,500 individuals, 1,800 singleton cases and 800 triads consisting of an affected individual and two parents. It is expected that the results of this GWAS will be published before December 2008. Thus, the aim of this proposal is to obtain funding that will allow this group to continue meeting to further establish collaborative working groups focused on different aspects of the genetics of OCD.

抽象的 这是对多年会议赠款的竞争续约，该赠款支持一个论坛，以供研究人员对强迫症的分子遗传学（OCD）进行协作研究。该应用与NIMH计划相一致，以促进会议，研究人员聚集在一起建立以促进易于精神疾病的基因的方式进行合作的机制。目前，大约有60名研究人员参加了该小组的会议。这些人来自13个外国和美国的38个不同的研究中心。 强迫症是一种严重的精神病疾病，对成人和儿童都会产生衰弱的影响。双胞胎和家庭聚集研究已经证明了遗传因素在强迫症中的重要性。此外，最近的分子遗传研究已经开始提供证据，表明特定基因可能在该疾病的表现中起作用。尽管这些初步结果令人鼓舞，但一些考虑因素表明，完全澄清强迫症的遗传结构将需要大量样本和协作努力。从对精神分裂症，自闭症，吉尔斯·德拉特雷特综合症，ADHD和双相情感障碍的遗传学的持续研究中可以清楚地看出，这与有关为复杂疾病定位基因定位基因的统计学考虑一致，即单个研究人员收集的样本可能不足以提供遗传链接的重要证据。此外，一旦证明了连接，甚至需要更大的样品尺寸来识别和表征敏感性基因。因此，很明显，需要协调合作来共享发现和池样本。 这种类型的合作研究通常很困难。在强迫性的基金会和NIMH的这项赠款的支持下，这组研究人员正在合作第一个基因组广泛的OCD研究。目前，来自19个不同地点的调查人员已同意将其强迫症样本结合起来。总样本由大约4,500个人，1,800个单例病例和800个三合会组成，由受影响的个体和两个父母组成。预计该GWA的结果将在2008年12月之前发布。因此，该提案的目的是获得资金，使该小组能够继续开会，以进一步建立关注OCD遗传学不同方面的协作工作组。

项目成果

Genome-wide association study of pediatric obsessive-compulsive traits: shared genetic risk between traits and disorder.

• DOI: 10.1038/s41398-020-01121-9
• 发表时间: 2021-02-02
• 期刊: Translational psychiatry
• 影响因子: 6.8
• 作者: Burton CL;Lemire M;Xiao B;Corfield EC;Erdman L;Bralten J;Poelmans G;Yu D;Shaheen SM;Goodale T;Sinopoli VM;OCD Working Group of the Psychiatric Genomics Consortium;Soreni N;Hanna GL;Fitzgerald KD;Rosenberg D;Nestadt G;Paterson AD;Strug LJ;Schachar RJ;Crosbie J;Arnold PD
• 通讯作者: Arnold PD