OC Foundation Genetics Collaborative Conference

OC基金会遗传学合作会议

• 批准号: 6887981
• 负责人: DAVID L PAULS
• 金额: $ 11.53万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-23 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6887981
• 关键词: genetic susceptibility; meeting /conference /symposium; molecular genetics; obsessive compulsive disorder; travel

DESCRIPTION (provided by applicant): A multi-year conference grant is being proposed to support a forum for researchers to pursue collaborative studies of the molecular genetics of obsessive compulsive disorder (OCD). This application is consistent with NIMH initiatives to facilitate meetings in which researchers come together to establish mechanisms for collaborating in a manner that would facilitate the detection of genes predisposing to psychiatric disorders. At the present time, there are approximately 50 researchers who have attended the first two meetings of this group. These individuals come from 12 foreign countries and from 13 different research centers in the United States. The group has already met twice and will be meeting again in April 2004. OCD is a serious psychiatric condition that can have debilitating affects on both adults and children. The importance of genetic factors in OCD has been demonstrated by twin and family aggregation studies. Furthermore, recent molecular genetic studies have begun to provide evidence that specific genes may play a role in the manifestation of the disorder. Although these preliminary results are encouraging, several considerations suggest that fully clarifying the genetic architecture of OCD will require large samples and collaborative efforts. It is clear from ongoing studies of the genetics of schizophrenia, autism, Gilles de la Tourette's syndrome, ADHD and bipolar disorder that are consistent with statistical considerations regarding the power to locate genes for complex disorders, that samples collected by individual investigators may not be sufficiently large to provide significant evidence for genetic linkage. Furthermore, once linkage has been demonstrated, even larger sample sizes are needed to identify and characterize susceptibility genes. Thus, it is clear that coordinated collaboration is needed to share findings and pool samples. Cooperative research of this type is often difficult. With the support of the Obsessive Compulsive Foundation, a group of investigators (described above) from around the world (the OCF Genetics Collaborative) have already begun to meet to address some of these issues. The OCF has funded the first two meetings of this group. However, its funds are limited and for the most part, donors to the OCF Research Fund indicate that they want the funds that they give to support specific research projects rather than meetings. Thus, the aim of this proposal is to obtain funding that will allow this group to continue meeting to establish collaborative working groups focused on different aspects of the genetics of OCD. The hope is that data from a variety of studies being done collaboratively among members of the group will be easily combined and stored in a general data repository to be used initially by all members of the OCF Genetics Collaborative and eventually by members of the scientific community at large.

描述（由申请人提供）：正在提出一项多年会议赠款，以支持一个论坛，以供研究人员对强迫症分子遗传学（OCD）进行协作研究。该应用与NIMH计划相一致，以促进会议，研究人员聚集在一起建立以促进易于精神疾病的基因的方式进行合作的机制。目前，大约有50名研究人员参加了该小组的前两次会议。这些人来自12 外国和美国13个不同的研究中心。该小组已经见面两次，并将在2004年4月再次开会。强迫症是一种严重的精神病疾病，可能会对成人和儿童产生衰弱的影响。双胞胎和家庭聚集研究已经证明了遗传因素在强迫症中的重要性。此外，最近的分子遗传研究已经开始提供证据，表明特定基因可能在该疾病的表现中起作用。 尽管这些初步结果令人鼓舞，但一些考虑因素表明，完全澄清强迫症的遗传结构将需要大量样本和协作努力。从对精神分裂症，自闭症，吉尔斯·德拉特雷特综合症，ADHD和双相情感障碍的遗传学的持续研究中可以清楚地看出，这与有关为复杂疾病定位基因定位基因的统计学考虑一致，即单个研究人员收集的样本可能不足以提供遗传链接的重要证据。此外，一旦证明了连接，就需要更大的样本量来识别和表征敏感性基因。因此，很明显，需要协调合作来共享发现和池样本。这种类型的合作研究通常很困难。在强迫性的基础的支持下，来自世界各地的一组研究人员（上述）（OCF遗传学协作）已经开始满足以解决其中一些问题。 OCF资助了该小组的前两次会议。但是，它的资金是 OCF研究基金的捐助者有限，并且在大多数情况下表明他们希望提供的资金支持特定的研究项目而不是会议。因此，该提案的目的是获得资金，使该小组能够继续开会，以建立关注强迫症遗传学各个方面的协作工作组。希望是，在小组成员中进行的各种研究中的数据将很容易合并并存储在一般数据存储库中，最初由OCF Genetics协作的所有成员使用，最终由整个科学界的成员使用。