BIOLOGY AND PATHOPHYSIOLOGY OF UROTHELIUM IN BLADDER DISEASE

膀胱疾病中尿路上皮的生物学和病理生理学

基本信息

批准号：
8597683
负责人：
GERALD Louis ANDRIOLE
金额：
$ 6.53万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-29 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8597683
关键词：
Affect Age Area Basal Cell Basic Science Benign Biological Assay Biology Bladder Bladder Diseases Bladder Injury Cells Clinical Clinical Research Clinical Trials Collaborations Collection Cytology Development Diagnostic Disease Educational Activities Enrollment Extracellular Matrix Fostering Foundations Functional disorder Gender Goals Histopathology Homeostasis Human Individual Infective cystitis Informatics Injury Interdisciplinary Study Lead Lower urinary tract Medical Students Microarray Analysis Modeling Molecular Mus Neuroanatomy Neurobiology Nociception Pain Pathologist Patients Process Protamine Sulfate Research Research Activity Research Infrastructure Research Personnel Research Project Grants Resources Scientist Specimen Stem cells Structure Students Testing Tissues Transitional Epithelium Translations Universities Urination Urine Urologic Diseases Urologist Urology Uropathogenic E. coli Urothelium Validation Visit Washington base bench to bedside bladder pain cohort college experience high school injury and repair interest mouse model multidisciplinary pre-clinical prognostic programs public health relevance repaired response response to injury synthetic polymer Bioplex

项目摘要

DESCRIPTION (provided by applicant): This is a proposal to establish an Interdisciplinary Research Center in Benign Urology focused on "Biology and Pathophysiology of Urothelium in Bladder Disease." The overarching, long term goals are to develop and integrate resources in basic and clinical investigation that will catalyze the rapid translation of breakthroughs in our understanding of the biology of bladder injury and repair from the preclinical to the clinical setting. The immediate goal of this Planning Center is to bring together an interdisciplinary team of researchers with diverse areas of expertise to formulate and establish a multi-pronged, systematic approach for investigating bladder injury and its effects in both mouse models and in human patients. The multidisciplinary Team includes practicing urologists, basic scientists, and pathologists with interests in bladder infection, injury, and repair processes; bladder pain, micturition and neurourology; urothelial stem cell homeostasis, activation, and interactions with extracellular matrix; and high throughput collection and banking of clinical information and specimens. The scientific research project has three Aims that will define cellular, molecular, and neurobiological changes that accompany various bladder injury models in mice and then correlate these with changes that occur in benign human bladder diseases. This process will also lead to establishment of much needed infrastructure to conduct multifaceted research in bladder diseases (bench to bedside). The Center includes an Administrative Core responsible for fostering collaborations and overseeing an Educational Enrichment Program. This Program will arrange visits to Washington University by outside speakers to present seminars relevant to the goals of the Center. In addition, the Program will support Summer Student Research Experiences in Urology-relevant labs for high school, college, and medical students. Together, the research and educational activities supported by the Center will allow the Team to make substantial inroads into understanding the biology of benign lower urinary tract urothelial diseases and the associated pain.

描述（由申请人提供）：这是一项建立良性泌尿外科跨学科研究中心的提案，重点关注“膀胱疾病中尿路上皮的生物学和病理生理学”。总体长期目标是开发和整合基础和临床研究的资源，这将促进我们对膀胱损伤和修复生物学的理解从临床前到临床的突破的快速转化。该规划中心的近期目标是汇集具有不同专业领域的跨学科研究人员团队，制定和建立多管齐下的系统方法来研究膀胱损伤及其对小鼠模型和人类患者的影响。多学科团队包括对膀胱感染、损伤和修复过程感兴趣的执业泌尿科医生、基础科学家和病理学家；膀胱疼痛、排尿和神经泌尿学；尿路上皮干细胞稳态、激活以及与细胞外基质的相互作用；以及临床信息和样本的高通量收集和存储。该科学研究项目有三个目标，将定义伴随小鼠各种膀胱损伤模型的细胞、分子和神经生物学变化，然后将这些变化与良性人类膀胱疾病中发生的变化联系起来。这一过程还将导致建立急需的基础设施，以对膀胱疾病进行多方面的研究（从实验室到床边）。该中心包括一个行政核心，负责促进合作和监督教育丰富计划。该计划将安排外部演讲者访问华盛顿大学，举办与中心目标相关的研讨会。此外，该计划还将支持高中生、大学和医学生在泌尿学相关实验室的暑期学生研究体验。该中心支持的研究和教育活动将使该团队在了解良性下尿路尿路上皮疾病和相关疼痛的生物学方面取得重大进展。