BIOLOGY AND PATHOPHYSIOLOGY OF UROTHELIUM IN BLADDER DISEASE

膀胱疾病中尿路上皮的生物学和病理生理学

• 批准号: 8566171
• 负责人: GERALD Louis ANDRIOLE
• 金额: $ 30.9万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-29 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8566171
• 关键词: Affect; Age; Area; Basal Cell; Basic Science; Benign; Biological Assay; Biology; Bladder; Bladder Diseases; Bladder Injury; Cells; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Cytology; Development; Diagnostic; Disease; Educational Activities; Enrollment; Extracellular Matrix; Fostering; Foundations; Functional disorder; Goals; Histopathology; Homeostasis; Human; Individual; Infective cystitis; Informatics; Injury; Instruction; Interdisciplinary Study; Lead; Lower urinary tract; Medical Students; Microarray Analysis; Modeling; Molecular; Mus; Neuroanatomy; Neurobiology; Nociception; Pain; Pathologist; Patients; Process; Protamine Sulfate; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Scientist; Specimen; Stem cells; Structure; Students; Testing; Tissues; Transitional Epithelium; Translations; Universities; Urination; Urine; Urologic Diseases; Urologist; Urology; Urothelium; Validation; Visit; Washington; base; bench to bedside; cohort; college; experience; high school; injury and repair; interest; mouse model; multidisciplinary; pre-clinical; prognostic; programs; repaired; response; response to injury; synthetic polymer Bioplex

This is a proposal to establish an Interdisciplinary Research Center in Benign Urology focused on "Biology and Pathophysiology of Urotheliunn in Bladder Disease." The overarching, long term goals are to develop and integrate resources in basic and clinical investigation that will catalyze the rapid translation of breakthroughs in our understanding of the biology of bladder injury and repair from the preclinical to the clinical setting. The immediate goal of this Planning Center is to bring together an interdisciplinary team of researchers with diverse areas of expertise to formulate and establish a multi-pronged, systematic approach for investigating bladder injury and its effects in both mouse models and in human patients. The multidisciplinary Team includes practicing urologists, basic scientists, and pathologists with interests in bladder infection, injury, and repair processes; bladder pain, micturition and neurourology; urothelial stem cell homeostasis, activation, and interactions with extracellular matrix; and high throughput collection and banking of clinical information and specimens. The scientific research project has three Aims that will define cellular, molecular, and neurobiological changes that accompany various bladder injury models in mice and then correlate these with changes that occur in benign human bladder diseases. This process will also lead to establishment of much needed infrastructure to conduct multifaceted research in bladder diseases (bench to bedside). The Center includes an Administrative Core responsible for fostering collaborations and overseeing an Educational Enrichment Program. This Program will arrange visits to Washington University by outside speakers to present seminars relevant to the goals of the Center. In addition, the Program will support Summer Student Research Experiences in Urology-relevant labs for high school, college, and medical students. Together, the research and educational activities supported by the Center will allow the Team to make substantial inroads into understanding the biology of benign lower urinary tract urothelial diseases and the associated pain.

这是建立良性泌尿外科跨学科研究中心的提案，重点关注“生物学” 和膀胱疾病中尿路上皮的病理生理学。”总体的长期目标是开发 整合基础和临床研究资源，促进药物快速转化 从临床前到临床，我们对膀胱损伤和修复生物学的理解取得了突破 临床环境。该规划中心的近期目标是汇集一支跨学科团队 具有不同专业领域的研究人员制定和建立多管齐下的系统方法 用于研究小鼠模型和人类患者的膀胱损伤及其影响。这 多学科团队包括执业泌尿科医生、基础科学家和对以下领域感兴趣的病理学家 膀胱感染、损伤和修复过程；膀胱疼痛、排尿和神经泌尿学；尿路上皮干 细胞稳态、激活以及与细胞外基质的相互作用；以及高通量收集和 临床信息和样本的银行。该科学研究项目有三个目标，将定义 小鼠和小鼠各种膀胱损伤模型伴随的细胞、分子和神经生物学变化 然后将这些与良性人类膀胱疾病中发生的变化联系起来。这个过程也将导致 建立急需的基础设施，以开展膀胱疾病的多方面研究（工作台 到床边）。该中心包括一个行政核心，负责促进合作和 监督教育强化计划。该项目将安排参观华盛顿大学 由外部发言人主持与中心目标相关的研讨会。此外，该计划将 支持暑期学生在高中、大学和泌尿学相关实验室的研究经验 医学生。该中心支持的研究和教育活动共同将使 团队在了解良性下尿路泌尿道上皮生物学方面取得重大进展 疾病和相关的疼痛。