PHENOTYPING OF LOWER URINARY SYMPTOMS AND DISORDER (PLUS)

下尿路症状和紊乱的表型分析 (PLUS)

• 批准号: 9296121
• 负责人: GERALD Louis ANDRIOLE
• 金额: --
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-15 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9296121
• 关键词: Adherence; Adult; Age; Bioinformatics; Bladder Control; Blood; Brain; Caucasians; Chronic Prostatitis; Clinical; Clinical Data; Communities; Data; Data Collection; Data Coordinating Center; Databases; Diffusion Magnetic Resonance Imaging; Disease; Disease Progression; Enrollment; Ensure; Female; Fiber; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Gender; Health; Incontinence; Individual; Industry; Interstitial Cystitis; Iowa; Lead; Lower urinary tract; Magnetic Resonance Imaging; Measures; Medical; Medical Records; National Institute of Diabetes and Digestive and Kidney Diseases; Outcome; Overactive Bladder; Participant; Pathology; Patient Outcomes Assessments; Patient Self-Report; Patients; Phenotype; Prefrontal Cortex; Protocols documentation; Public Health Informatics; Recording of previous events; Recruitment Activity; Research; Research Personnel; Rest; Site; Subgroup; Surrogate Markers; Symptoms; Target Populations; Techniques; Underrepresented Minority; United States National Institutes of Health; Universities; Urine; Urologic Diseases; Urologic Surgical Procedures; Urology; Washington; Wireless Technology; base; biobank; clinical phenotype; experience; health related quality of life; informatics infrastructure; innovation; innovative technologies; instrument; male; multidisciplinary; nervous system disorder; neuroimaging; next generation; novel; patient population; personalized therapeutic; prospective; public health relevance; socioeconomics; tool; urinary; urologic; white matter

DESCRIPTION (provided by applicant): The objectives of this proposal are to: (1) recruit subjects with lower urinary tract disorders (LUTDs) to validate the new patient-reported outcome (PRO) tools currently being developed by NIDDK LURN Research Network, and (2) use innovative technologies to extensively phenotype a targeted population to expand our understanding of the pathophysiology of LUTD. We have assembled a multidisciplinary team of investigators with recognized expertise in male and female LUTDs, urologic phenotyping research, bioinformatics, wireless technologies, functional MRI, and structural neuroimaging. In Aim 1, we proposed a systematic, data-driven, targeted approach to recruit subjects with LUTDs to validate the new LURN PRO instruments. In Aim 2, we will enroll subjects with overactive bladder (OAB), systematically collect their phenotype, symptom data and biospecimens using existing bioinformatics pipeline and wireless technologies at Washington University, and prospectively follow them up for 12 months to identify predictors of OAB progression or regression. In Aim 3, we will use innovative neuroimaging techniques to phenotype OAB patients with and without incontinence.

描述（由申请人提供）：本提案的目标是：(1) 招募患有下尿路疾病 (LUTD) 的受试者来验证 NIDDK LURN 研究网络目前正在开发的新患者报告结果 (PRO) 工具，以及(2) 使用创新技术对目标人群进行广泛的表型分析，以扩大我们对 LUTD 病理生理学的理解。我们组建了一支多学科研究人员团队，他们在男性和女性 LUTD、泌尿表型研究、生物信息学、无线技术、功能 MRI 和结构神经影像方面拥有公认的专业知识。在目标 1 中，我们提出了一种系统的、数据驱动的、有针对性的方法来招募具有 LUTD 的受试者来验证新的 LURN PRO 仪器。在目标 2 中，我们将招募膀胱过度活动症 (OAB) 受试者，利用华盛顿大学现有的生物信息学流程和无线技术系统地收集他们的表型、症状数据和生物样本，并对他们进行为期 12 个月的前瞻性随访，以确定 OAB 进展或预测的预测因素。回归。在目标 3 中，我们将使用创新的神经影像技术对患有或不患有失禁的 OAB 患者进行表型分析。