Neural Mechanisms Underlying Nicotine and Alcohol Combinations: Quantitative fMRI

尼古丁和酒精组合背后的神经机制：定量功能磁共振成像

• 批准号: 8423709
• 负责人: LISA D NICKERSON
• 金额: $ 18.04万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-15 至 2014-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8423709
• 关键词: Acute; Alcohol consumption; Alcoholism; Alcohols; Area; Biological; Blood Volume; Blood flow; Brain; Brain imaging; Caffeine; Cessation of life; Complex; Core-Binding Factor; Data; Development; Diffusion; Disease; Drug Combinations; Drug usage; Functional Magnetic Resonance Imaging; Future; Goals; Health; Hour; Image; Imaging Techniques; Intake; Light; Link; Magnetic Resonance Imaging; Measurement; Measures; Metabolism; Methods; Modality; Motor; Nature; Neurons; Neurophysiology - biologic function; Nicotine; Oxygen; Participant; Pattern; Perfusion; Persons; Pharmaceutical Preparations; Physiological; Physiological Effects of Drugs; Placebos; Psychotropic Drugs; Randomized; Research; Research Design; Research Methodology; Rest; Rewards; Scanning; Smoke; Smoker; Smoking; Spin Labels; Study Subject; Task Performances; Techniques; Testing; Time; Visual; alcohol effect; alcohol testing; base; blood oxygenation level dependent response; cerebrovascular; cognitive function; drinking; drug of abuse; drugged driving; imaging modality; independent component analysis; innovation; insight; mesolimbic system; neuromechanism; nicotine patch; non-smoker; novel; novel strategies; problem drinker; relating to nervous system; research study; response; volunteer

Long-term Objectives: Our long-term objective is to bring together non-invasive quantitative functional magnetic resonance imaging (q-fMRI) with a newly developed cutting-edge analysis method to study changes in neuronal metabolism and cerebrovascular function that occurs during psychoactive drug use. Specific Aims: Our first specific aim is to validate the components of the q-fMRI acquisition, which requires several different kinds of fMRI scans (or multimodal measurements). The second aim then applies the q-MRI method to study the functional brain networks that define brain activity when a person is simply resting and not engaged in any activity. These networks each consist of a unique set of regions that spontaneously fluctuate together in order to be "tuned" for future task performance. The effects of nicotine and alcohol and their interaction on these resting state networks are the focus of the application of our new q-fMRI strategy. q-fMRI measurements require several different scans, including making measurements of perfusion and oxygen metabolism, and an integrated analysis of all of these different results will be much more informative than separate analyses of each measurement. However, the analysis method, the linked independent component analysis (linked ICA) approach is very new and has never been applied to q-fMRI measurements or any other measurements of psychoactive drug effects. Thus, the third aim is to apply this novel analysis method to data acquired under different drug conditions to identify patterns of related activity in our multimodal fMRI data. Research Design and Methods: A randomized within-subject study of 23 healthy subjects will be done as follows: fMRI scanning will begin four hours after pre-treatment with either nicotine or placebo patch (randomized). Alcohol will then be consumed by subjects while in the scanner and a second scanning session will be done of the combination of nicotine (placebo) + alcohol to assess changes in resting state functional connectivity due to alcohol and nicotine and their interactions. Significance: Linked ICA with q-fMRI measurements is an innovative strategy for studying brain function that could have a significant impact in the ability of fMRI to give an integrated picture of the spectrum of effects that drugs of abuse may have on brain function, and is thus ideally suited to the goals of the CEBRA mechanism. By applying this technique to study alcohol and nicotine co-use, we also will contribute greatly to the understanding of this significant health problem.

长期目标：我们的长期目标是将非侵入性定量功能汇总在一起 磁共振成像（Q-FMRI）采用新开发的尖端分析方法来研究变化 在精神活性药物使用过程中发生的神经元代谢和脑血管功能。 具体目的：我们的第一个具体目的是验证Q-FMRI获取的组成部分，这需要 几种不同类型的fMRI扫描（或多模式测量值）。然后，第二个目标应用Q-MRI 研究一个人只是休息而不是，研究大脑活动的功能性脑网络而不是 从事任何活动。这些网络每个由自发波动的独特区域组成 为了“调整”未来的任务绩效，一起。尼古丁和酒精的影响及其 这些休息状态网络上的互动是我们新Q-FMRI策略应用的重点。 Q-FMRI 测量需要几种不同的扫描，包括对灌注和氧气进行测量 代谢以及对所有这些不同结果的综合分析将比 对每个测量的单独分析。但是，分析方法，链接的独立组件 分析（链接的ICA）方法非常新，并且从未应用于Q-FMRI测量或任何其他 精神活性药物作用的测量。因此，第三个目的是将这种新颖的分析方法应用于数据 在不同的药物条件下获得，以鉴定我们多模式fMRI数据中相关活动的模式。 研究设计和方法：将对23名健康受试者进行随机的受试者内研究 以下内容：fMRI扫描将在使用尼古丁或安慰剂贴片预处理后四个小时开始 （随机）。然后，在扫描仪和第二次扫描课程中，受试者将饮酒被摄取 将通过尼古丁（安慰剂） +酒精的组合来评估静止状态功能的变化 由于酒精和尼古丁及其相互作用而引起的连通性。 意义：将ICA与Q-FMRI测量相关联是研究大脑功能的创新策略 可以对fMRI的能力产生重大影响 滥用药物可能具有大脑功能，因此非常适合CEBRA机制的目标。 通过将此技术应用于研究酒精和尼古丁共同利用，我们还将为 了解这个重大健康问题。