Novel Use of fMRI to Study Substance Abuse Problems

功能磁共振成像研究药物滥用问题的新用途

• 批准号: 7033000
• 负责人: LISA D NICKERSON
• 金额: $ 11.68万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7033000
• 关键词: adolescence (12-20); auditory discrimination; behavior test; behavioral /social science research tag; behavioral habituation /sensitization; behavioral medicine; bioimaging /biomedical imaging; brain; clinical research; cognition disorders; craving; cues; functional magnetic resonance imaging; human subject; marijuana abuse; olfactory disorder; patient oriented research; psychophysiology; statistics /biometry; substance abuse related behavior; substance abuse related disorder; visual perception; young adult human (21-34); adolescence (12-20); auditory discrimination; behavior test; behavioral /social science research tag; behavioral habituation /sensitization; behavioral medicine; bioimaging /biomedical imaging; brain; clinical research; cognition disorders; craving; cues; functional magnetic resonance imaging; human subject; marijuana abuse; olfactory disorder; patient oriented research; psychophysiology; statistics /biometry; substance abuse related behavior; substance abuse related disorder; visual perception; young adult human (21-34)

DESCRIPTION (provided by applicant): This is a request for five years of funding through the K25 Quantitative Mentored Research Career Development Award mechanism. The candidate, an imaging physicist and statistician, has proposed an intensive training and research program to facilitate her growth as an interdisciplinary scientist, capable of obtaining support for the development of newly emerging functional magnetic resonance imaging (fMRI) techniques to study substance abuse problems. The training plan reflects a combination of coursework, laboratory visits, and meetings to provide formal training in the areas of neuroscience and substance abuse that will both complement the experience of and expedite the successful completion of the research projects. The use of fMRI to study drug abuse problems is still relatively uncommon, but in general, holds great promise for this application, fMRI methods - both study designs and data/statistical analyses - are still evolving at a very rapid pace; this can be an incredible obstacle for investigators who wish to utilize fMRI but do not have the imaging background to select an appropriate study design. The research plan focuses on the optimization of novel fMRI techniques to study aspects of marijuana use in adolescents and adults and on the dissemination of these lesser known, yet incredibly flexible, methods to the substance abuse research community. The first project investigates differences in reactivity to visual, audio, and olfactory drug cues between adolescents and adults who use marijuana. Subjective responses (self-reports of cue-induced marijuana craving) and physiological responses (skin temperature, heart rate, and skin conductance) will be recorded and analyzed using multivariate statistical methods. Responses for both groups will also be compared with responses from healthy matched control subjects. The second project is an event-related fMRI study of the effects of cue induced craving on performance of an oddball task in adolescent and adult marijuana users (healthy matched control subjects will also be tested). The study design and data analysis strategy will permit the assessment of two different aspects of craving, each over a different time scale. The third project is a pharmacological fMRI (phMRI) study that will tackle the question of how acute administration of marijuana effects brain activity in adult marijuana users. The phMRI methods will be optimized to balance the impact of the unwieldy pharmacokinetic properties of marijuana and the small and temporally variable cognitive effects. All together, these three projects will constitute an invaluable training experience for the candidate while demonstrating the versatility of newer fMRI techniques in studying substance abuse problems and providing a better understanding of marijuana effects in adolescents and adults.

描述（由申请人提供）： 这是通过K25定量指导的研究职业发展奖机制进行五年资金的要求。这位候选人是一名成像物理学家和统计学家，他提出了一项强化培训和研究计划，以促进她作为跨学科科学家的成长，能够获得对新出现的新出现的功能磁共振成像（FMRI）技术的支持，以研究药物滥用问题。该培训计划反映了课程工作，实验室访问和会议的结合，以在神经科学和药物滥用领域提供正式培训，这些培训既可以补充研究项目的经验，又可以加快成功完成研究项目的经验。使用fMRI来研究药物滥用问题仍然相对罕见，但总的来说，对于这种应用，fMRI方法（研究设计和数据/统计分析）仍在以非常快速的速度发展。对于希望利用fMRI但没有成像背景来选择适当研究设计的研究人员来说，这可能是一个令人难以置信的障碍。该研究计划的重点是优化新颖的功能磁共振成像技术，以研究青少年和成人中大麻使用方面的各个方面，以及传播这些鲜为人知的，但令人难以置信的灵活方法，以对药物滥用研究社区进行。第一个项目研究了青少年和使用大麻的成年人之间对视觉，音频和嗅觉药物提示的反应性差异。将使用多变量统计方法记录和分析主观反应（提示引起的大麻渴望的自我报告）和生理反应（皮肤温度，心率和皮肤电导）。两组的响应也将与健康匹配的对照受试者的响应进行比较。第二个项目是与事件相关的功能磁共振成像研究，该研究对提示诱发的渴望对青少年和成人大麻使用者的奇怪任务的效果（也将测试健康匹配的控制受试者）。研究设计和数据分析策略将允许评估渴望的两个不同方面，每个方面在不同的时间范围内。第三个项目是一项药理功能磁共振成像（PHMRI）研究，该研究将解决成年大麻使用者中急性给药大麻活动的问题。 PHMRI方法将被优化，以平衡大麻笨拙的药代动力学特性的影响以及小且具有时间变化的认知效应。总而言之，这三个项目将为候选人构成宝贵的培训经验，同时证明了新的fMRI技术在研究药物滥用问题方面的多功能性，并为青少年和成人的大麻影响提供了更好的了解。