NUTRITIONAL MANAGEMENT OF INFANTS WITH BRONCHOPULMONARY DYSPLASIA (BPD): EFFE

支气管肺发育不良 (BPD) 婴儿的营养管理：EFFE

• 批准号: 7950631
• 负责人: STEVEN A ABRAMS
• 金额: $ 0.32万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950631
• 关键词: Affect; Body Composition; Bronchopulmonary Dysplasia; Chronic; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Disease Management; Funding; Grant; Growth; Growth and Development function; Head circumference; Hospitalization; Human Milk; Infant; Institution; Intake; Lead; Length; Liquid substance; Lung; Minerals; Nutritional; Outcome; Pulmonary Edema; Research; Research Personnel; Resources; Respiratory physiology; Source; United States National Institutes of Health; Very Low Birth Weight Infant; Weight Gain; bone; calcium absorption; calcium metabolism; density; expectation; feeding; improved; in utero

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bronchopulmonary Dysplasia (BPD) affects approximately one-fourth of very low birth weight infants (VLBW) and results in chronic pulmonary sequelae and the potential for impaired growth and development. Although somatic growth is associated with improved lung function, management of this disorder frequently includes fluid restriction to minimize pulmonary edema. The optimal way to maximize nutritional intake when fluid is restricted and the effects of the common practice of increasing caloric density (above 24 kcal/oz) on growth, calcium metabolism and bone mineral status are unknown. Despite restricted volume intake, providing either preterm formula or human milk fortified to 27 kcal/oz (0.9 kcal/mL) for 6 weeks to VLBW infants with evolving BPD will lead to calcium absorption, bone and somatic growth in infants comparable to infants who do not have BPD and are fed higher volumes of fortified human milk or formula at 24 kcal/oz (0.8 kcal/mL). These results will support the use of high caloric density feedings in infants with BPD to achieve both bone and overall growth outcomes close to those achievable in utero. Weight gain in each group will average 15-20 g/kg/d, consistent with expectations and mean length (1.0 cm/wk) and head circumference (0.8 cm/wk) will similarly increase at in utero levels. Primary Aim: To compare the effects of different feeding strategies on calcium absorption in Very Low Birth Weight (VLBW) infants with and without evolving bronchopulmonary dysplasia (BPD). Secondary Aim: To evaluate growth and body composition in VLBW infants provided 120 kcal/kg/d feeding during hospitalization.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 支气管肺发育不良 (BPD) 影响大约四分之一的极低出生体重婴儿 (VLBW)，并导致慢性肺部后遗症以及潜在的生长和发育受损。尽管躯体生长与肺功能改善相关，但这种疾病的治疗通常包括限制液体以尽量减少肺水肿。当液体受到限制时，最大化营养摄入的最佳方法以及增加热量密度（高于 24 kcal/oz）的常见做法对生长、钙代谢和骨矿物质状态的影响尚不清楚。 尽管摄入量受到限制，但向患有 BPD 的 VLBW 婴儿提供强化至 27 kcal/oz (0.9 kcal/mL) 的早产配方奶粉或母乳 6 周，将导致婴儿的钙吸收、骨骼和躯体生长与患有 BPD 的婴儿相当。没有 BPD，并喂食大量 24 kcal/oz (0.8 kcal/mL) 的强化母乳或配方奶。这些结果将支持对 BPD 婴儿使用高热量密度喂养，以实现接近子宫内可达到的骨骼和整体生长结果。每组的体重平均增加 15-20 克/公斤/天，与预期一致，平均身长 (1.0 厘米/周) 和头围 (0.8 厘米/周) 在子宫内水平也会类似增加。 主要目的：比较不同喂养策略对患有或不患有支气管肺发育不良 (BPD) 的极低出生体重 (VLBW) 婴儿钙吸收的影响。 次要目标：评估住院期间每天喂食 120 kcal/kg 的 VLBW 婴儿的生长和身体成分。