Reliability of Cognitive ERPs in Children and Adults

儿童和成人认知 ERP 的可靠性

• 批准号: 6921708
• 负责人: PATRICIA L DAVIES
• 金额: $ 7.25万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6921708
• 关键词: adolescence (12-20); age difference; attention; auditory discrimination; behavior test; bioimaging /biomedical imaging; brain electrical activity; brain mapping; clinical research; developmental neurobiology; electroencephalography; evoked potentials; executive function; human subject; middle childhood (6-11); young adult human (21-34)

DESCRIPTION (provided by applicant): The long-term goals of this program of research are to contribute to the increasing amount of evidence for continued development of the brain into early adulthood. Electroencephalographic (EEC) measures and neuropsychological assessments are being employed to investigate the interrelationships of maturation of specific brain regions and the development of cognitive and emotional processes in children and adolescents. The results obtained from this study will be applied to the development of a model that will elucidate interrelationships of variables representing stimulus-response mechanisms, trait, and state characteristics of an individual and their associated changes in various ERP measurements observed during periodic assessments in typically developing children using a longitudinal design. The goals of the proposed research are to: 1) Determine if developmental trends exist in the reliability of ERPs, and 2) Clarify the relationship of executive functions, specifically attention, to ERPs components and ERP reliability. The research design entails obtaining multiple channel EEC recordings from 30 participants in each of 3 age groups (8-yr olds, 12-yr olds and young adults) while performing 3 ERP paradigms: the novelty auditory oddball (an auditory discrimination task), contingent negative variation (a sustained attention task), and the error-related negativity (error-monitoring in simple visual discrimination task). Each participant will complete these EEG/ERP tasks in each of 2 visits separated by a 1-2 week period. Split-half and test-retest reliability coefficients will then be determined for the principle components of these ERP paradigms. Split-half and test-retest will then be recomputed using the standardized residuals instead of the original ERP measures. These new reliability coefficients are expected to be higher than those not accounting for variance due to waveform processing. Relationships of attentional measures and ERP reliability and the ERP components (i.e, CNV, P3a, P3b and ERN) will be evaluated. Health related impacts include understanding changes in the brain in relation to attention in childhood and adolescence. In addition, results have the potential of providing a wealth of information regarding individual differences in cognitive ERPs and ERP reliability. This information will be helpful, especially when clinical populations (e.g., attention deficit disorders and learning disabilities) are included in developmental ERP studies.

描述（由申请人提供）：这项研究计划的长期目标是为越来越多的证据促进大脑持续发展到成年初期的证据。脑电图（EEC）措施和神经心理学评估正在用于研究特定大脑区域成熟的相互关系以及儿童和青少年认知和情感过程的发展。从这项研究中获得的结果将应用于模型的开发，该模型将阐明代表刺激反应机制，性状和状态特征的变量的相互关系，及其在典型发育中的儿童定期评估期间观察到的各种ERP测量中的相关变化。拟议的研究的目标是：1）确定ERP的可靠性中是否存在发展趋势，以及2）阐明执行功能（特别是注意力）与ERP组件和ERP可靠性的关系。研究设计需要从3个年龄组中的每个参与者（8岁，12岁的年龄和年轻人和年轻人）中获得多个通道EEC记录，同时执行3种ERP范式：新颖的听觉奇数球（听觉歧视任务）（一种偶然的负面差异（持续的注意任务）（一个持续的关注任务），以及错误的负面率（误差率），视觉上是错误的（误解）。每个参与者将在两次访问中的每一个中完成这些EEG/ERP任务，分别为1-2周。然后将确定半分和重测的可靠性系数，以确定这些ERP范式的原理成分。然后将使用标准化残差而不是原始的ERP测量来重新计算分裂和重新测试。这些新的可靠性系数预计将高于由于波形处理而没有考虑不考虑差异的系数。注意力测量与ERP可靠性与ERP组件（即CNV，P3A，P3B和ERN）的关系将进行评估。与健康相关的影响包括了解与儿童期和青春期关注有关的大脑变化。此外，结果有可能提供有关认知ERP和ERP可靠性中个体差异的大量信息。这些信息将有所帮助，尤其是当临床人群（例如注意力缺陷障碍和学习障碍）中包括在发育性ERP研究中时。