Sensory Gating Mediated by Attention

由注意力介导的感觉门控

基本信息

批准号：
7268957
负责人：
PATRICIA L DAVIES
金额：
$ 7.14万
依托单位：
COLORADO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-08-01 至 2009-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7268957
关键词：
Adult Age Attention Auditory Autistic Disorder Brain Child Child Development Condition Data Development Disease Early identification Electroencephalography Event Event-Related Potentials Family history of Future Gene Abnormality Genetic Predisposition to Disease Goals Health Hearing Individual Instruction Knowledge Lead Measures Mediating Mental disorders Modeling Nature Neuraxis Neurodevelopmental Disorder Nicotinic Receptors Numbers Outcome Participant Performance Prefrontal Cortex Procedures Protocols documentation Publishing Purpose Receptor Gene Research Research Design Research Personnel Role Sampling Schizophrenia Sensory Sensory Process Standards of Weights and Measures Stimulus Stress Testing Treatment Effectiveness Variant Visit Work auditory stimulus base behavior measurement cost efficient design executive function improved interest movie neuromechanism noradrenergic programs sensory gating sensory stimulus skills trait trend young adult

项目摘要

DESCRIPTION (provided by applicant): The long-term goals of this program of research on sensory gating in children is based on building a multivariate model that will help elucidate which factors contribute to measuring stable sensory gating in children and testing the model to determine if it functions similarly for children and adults. The model states that measures of sensory gating may vary from individual to individual because the outcome represents an interaction of stimulus presentation protocols, such as stimulus intensity, number of trials, and task instructions, with several trait and state variables of the participant including but not limited to maturation of prefrontal cortex and executive function (attention), alpha/ nicotinic acetylcholine receptor gene (gene abnormalities), and stress level at electroencephalography (EEC) testing (noradrenergic tone). The proposed project will contribute to understanding the role of attention in this model of sensory gating. The three specific aims of the project are: 1) To determine if the manipulation of attention will differentially effect sensory gating in adults and children; 2) To demonstrate that the developmental nature of attention coincides with changes in levels of sensory gating in children; and 3) To determine the split-half and test-retest reliability measures of sensory gating in children and adults. The research design entails assessing 40 young adults and 40 children, ages 6 to 12 years, during two visits. EEC data will be collected using 3 variations of the Sensory Gating event-related potential (ERP) paradigm which manipulate the focus of attention. One version will be used twice, once on each visit, in order to obtain test-retest reliability measures. To investigate maturation of attention in children and its relationship to changes in sensory gating performance, several behavioral measures of attention will be obtained. The health related impact of the project is a better understanding of the variability in sensory gating measures observed in children. Such knowledge will lead to more reliable and objective measures of the brain's ability and inability to gate sensory information which will allow valid early identification of neurodevelopmental disorders such as in schizophrenia and autism. Improved measures of sensory gating may lead to productive and cost efficient studies assessing treatment effectiveness.

描述（由申请人提供）：关于儿童感觉门控的该研究计划的长期目标是基于建立多元模型，该模型将有助于阐明哪些因素有助于衡量儿童中稳定的感觉门控和测试模型以确定其对儿童和成人的作用是否相似。 The model states that measures of sensory gating may vary from individual to individual because the outcome represents an interaction of stimulus presentation protocols, such as stimulus intensity, number of trials, and task instructions, with several trait and state variables of the participant including but not limited to maturation of prefrontal cortex and executive function (attention), alpha/ nicotinic acetylcholine receptor gene (gene abnormalities),和脑电图（EEC）测试（去肾上腺素能张力）的应力水平。拟议的项目将有助于理解注意力在这种感觉门票模型中的作用。该项目的三个特定目的是：1）确定注意力的操纵是否会在成人和儿童的感觉门上有所不同； 2）证明注意力的发展性质与儿童感觉门控水平的变化一致； 3）确定儿童和成人感觉门控的半分和重测可靠性度量。研究设计需要评估40名年轻人和40名6至12岁的儿童，两次访问。 EEC数据将使用3种与操纵注意力焦点的感觉门控事件相关电位（ERP）范式的变体收集。每次访问一次一次，将使用一个版本两次，以获得重测的可靠性指标。为了研究儿童注意力的成熟及其与感觉门控性能变化的关系，将获得几种行为指标。该项目与健康相关的影响是更好地理解儿童中观察到的感觉门控措施的变异性。这些知识将导致对大脑能力和无法掌握感官信息的更可靠和客观的衡量，这将允许早期鉴定神经发育障碍，例如精神分裂症和自闭症。改进的感觉门控措施可能会导致评估治疗有效性的富有成效和高效的研究。