Sensory Gating Mediated by Attention

由注意力介导的感觉门控

基本信息

批准号：
7268957
负责人：
PATRICIA L DAVIES
金额：
$ 7.14万
依托单位：
COLORADO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-08-01 至 2009-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7268957
关键词：
Adult Age Attention Auditory Autistic Disorder Brain Child Child Development Condition Data Development Disease Early identification Electroencephalography Event Event-Related Potentials Family history of Future Gene Abnormality Genetic Predisposition to Disease Goals Health Hearing Individual Instruction Knowledge Lead Measures Mediating Mental disorders Modeling Nature Neuraxis Neurodevelopmental Disorder Nicotinic Receptors Numbers Outcome Participant Performance Prefrontal Cortex Procedures Protocols documentation Publishing Purpose Receptor Gene Research Research Design Research Personnel Role Sampling Schizophrenia Sensory Sensory Process Standards of Weights and Measures Stimulus Stress Testing Treatment Effectiveness Variant Visit Work auditory stimulus base behavior measurement cost efficient design executive function improved interest movie neuromechanism noradrenergic programs sensory gating sensory stimulus skills trait trend young adult

项目摘要

DESCRIPTION (provided by applicant): The long-term goals of this program of research on sensory gating in children is based on building a multivariate model that will help elucidate which factors contribute to measuring stable sensory gating in children and testing the model to determine if it functions similarly for children and adults. The model states that measures of sensory gating may vary from individual to individual because the outcome represents an interaction of stimulus presentation protocols, such as stimulus intensity, number of trials, and task instructions, with several trait and state variables of the participant including but not limited to maturation of prefrontal cortex and executive function (attention), alpha/ nicotinic acetylcholine receptor gene (gene abnormalities), and stress level at electroencephalography (EEC) testing (noradrenergic tone). The proposed project will contribute to understanding the role of attention in this model of sensory gating. The three specific aims of the project are: 1) To determine if the manipulation of attention will differentially effect sensory gating in adults and children; 2) To demonstrate that the developmental nature of attention coincides with changes in levels of sensory gating in children; and 3) To determine the split-half and test-retest reliability measures of sensory gating in children and adults. The research design entails assessing 40 young adults and 40 children, ages 6 to 12 years, during two visits. EEC data will be collected using 3 variations of the Sensory Gating event-related potential (ERP) paradigm which manipulate the focus of attention. One version will be used twice, once on each visit, in order to obtain test-retest reliability measures. To investigate maturation of attention in children and its relationship to changes in sensory gating performance, several behavioral measures of attention will be obtained. The health related impact of the project is a better understanding of the variability in sensory gating measures observed in children. Such knowledge will lead to more reliable and objective measures of the brain's ability and inability to gate sensory information which will allow valid early identification of neurodevelopmental disorders such as in schizophrenia and autism. Improved measures of sensory gating may lead to productive and cost efficient studies assessing treatment effectiveness.

描述（由申请人提供）：该儿童感觉门控研究计划的长期目标是建立一个多变量模型，该模型将有助于阐明哪些因素有助于测量儿童稳定的感觉门控并测试该模型以确定是否它对儿童和成人的作用相似。该模型指出，感觉门控的测量可能因人而异，因为结果代表刺激呈现协议的相互作用，例如刺激强度、试验次数和任务指令，以及参与者的几个特征和状态变量，包括但不包括仅限于前额皮质和执行功能（注意力）的成熟、α/烟碱乙酰胆碱受体基因（基因异常）以及脑电图（EEC）测试时的压力水平（去甲肾上腺素能音调）。拟议的项目将有助于理解注意力在这种感觉门控模型中的作用。该项目的三个具体目标是： 1）确定注意力的操纵是否会对成人和儿童的感觉门控产生不同的影响； 2）证明注意力的发展本质与儿童感觉门控水平的变化相一致； 3) 确定儿童和成人感觉门控的分半和重测可靠性指标。该研究设计需要在两次访问期间对 40 名年轻人和 40 名 6 至 12 岁的儿童进行评估。 EEC 数据将使用操纵注意力焦点的感觉门控事件相关电位 (ERP) 范式的 3 种变体来收集。一个版本将使用两次，每次访问一次，以获得重测可靠性指标。为了研究儿童注意力的成熟及其与感觉门控性能变化的关系，将获得几种注意力的行为测量。该项目与健康相关的影响是更好地了解儿童中观察到的感觉门控测量的变异性。这些知识将导致对大脑门控感觉信息的能力和能力进行更可靠和客观的测量，这将有助于有效地及早识别神经发育障碍，例如精神分裂症和自闭症。改进的感觉门控措施可能会导致评估治疗效果的富有成效且具有成本效益的研究。