COGNITIVE EVENT-RELATED POTENTIALS AND BRAIN MATURATION

认知事件相关潜力和大脑成熟

• 批准号: 2697146
• 负责人: PATRICIA L DAVIES
• 金额: $ 8.3万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-10 至 2003-05-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2697146
• 关键词: adolescence (12-20); age difference; behavior test; behavioral /social science research tag; brain electrical activity; clinical research; cognition; developmental neurobiology; electroencephalography; evoked potentials; human subject; middle childhood (6-11); neural information processing; performance; prefrontal lobe /cortex; young adult human (21-34)

The maturation of the frontal lobe of the brain may play an important role in the development of information processing abilities. Recordings of EEG and event-related potentials (ERPs) permit the examination of regional brain activity during the performance of specific information processing tasks. The goals of this research plan are: 1) to establish electrophysiological markers of development through adolescence; and 2) to relate the electrophysiological data to cognitive performance changes that occur in adolescence. This process will allow us to relate regional brain development as reflected in electrophysiological data to behavioral changes across ages. Three hypotheses are to be examined: 1) ERP patterns that are reflective of specific cognitive functioning will vary for participants of different ages; 2) ERPs associated with posterior regions of the brain will manifest adult properties at a younger age than ERPs associated with frontal regions of the brain; and 3) the ERP data will correlate with performance on behavioral tasks. These hypothesis will be tested by examining ERP components recorded while children and young adults perform specific information processing tasks. The educational objectives of this mentored research scientist award are: 1) The PI will expand research skills and extend research network. Dr. Sid Segalowitz will serve as mentor for this experience in the laboratory. The PI will attend courses that reinforce the laboratory experience. 2) Advance research wills of PI and develop new research projects addressing clinical intervention in rehabilitation. This will be accomplished through the completion of the research plan and the initiation of pilot studies that will examine ERP patterns in children with disabilities. 3) Promote skills in the dissemination of research results and laboratory management. The PI will prepare manuscripts for peer reviewed journals reporting the results of these studies and supervise graduate students in related research projects.

大脑额叶的成熟可能起重要作用 在信息处理能力的发展中。脑电图的录音 和事件相关电位（ERP）允许检查区域 特定信息处理过程中的大脑活动 任务。该研究计划的目标是：1）建立 通过青春期发育的电生理标记；和2）到 将电生理数据与认知性能变化相关联 在青春期发生。这个过程将使我们能够联系区域大脑 在电生理数据中反映到行为的发展 各个时代的变化。要检查三个假设：1）ERP模式 反映特定认知功能的特定认知功能会有所不同 不同年龄的参与者； 2）与后区相关的ERP 大脑的年龄比ERP年轻的成人特性表现 与大脑的额叶区域相关； 3）ERP数据将 与行为任务的性能相关。这些假设将是 通过检查儿童和年轻时记录的ERP组件测试 成人执行特定的信息处理任务。 这项指导研究科学家奖的教育目标是： 1）PI将扩大研究技能并扩展研究网络。 SID博士 Segalowitz将担任实验室经验的导师。这 PI将参加增强实验室经验的课程。 2） PI的预先研究意愿并开发了针对的新研究项目 康复的临床干预。这将通过 研究计划的完成和试点研究的启动 这将检查残疾儿童的ERP模式。 3）促进 扩展研究结果和实验室管理方面的技能。 PI将为同行评审的期刊准备手稿，报告 这些研究的结果并监督研究生 研究项目。