Interdisciplinary center of excellence for the study of pain and sensory function

疼痛和感觉功能研究跨学科卓越中心

• 批准号: 8529574
• 负责人: IAN D MENG
• 金额: $ 187.56万
• 依托单位: UNIVERSITY OF NEW ENGLAND
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8529574
• 关键词: Acute; Acute Pain; Adverse effects; Advisory Committees; Affect; Animal Behavior; Animal Experimentation; Basic Science; Behavioral; Biological Products; Centers of Research Excellence; Chemistry; Chronic; Clinical; Collaborations; Commit; Complement; Consultations; Core Facility; Development; Development Plans; Economics; Equipment; Faculty; Fostering; Foundations; Functional disorder; Funding; Future; Goals; Health; Histology; Human Resources; Humidity; Image; Individual; Industry; Institution; Investments; Knowledge; Laboratories; Learning; Memory; Mentors; Mentorship; Neurobiology; Neuronal Plasticity; Neurosciences; Neurosciences Research; New England; Noise; Pain; Pain Research; Pain management; Pharmaceutical Chemistry; Pharmacologic Substance; Pharmacy facility; Process; Quality of life; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Science; Scientist; Sensory; Temperature; Testing; Universities; career; career development; chronic pain; college; design; drug candidate; drug development; drug discovery; experience; functional improvement; inflammatory pain; innovation; interest; member; multidisciplinary; novel; painful neuropathy; prevent; programs; research and development; restoration; social; success; tool

DESCRIPTION (provided by applicant): Although research has vastly increased our knowledge regarding the basic mechanisms of acute, inflammatory and neuropathic pain, relatively little is known about the processes involved in the transition from acute to chronic pai. The goal of this COBRE application is to develop a Center of Biomedical Research Excellence that will significantly contribute to the scientific understanding of the neurobiology of chronic pin and sensory function, facilitating the discovery and development of novel therapies. The proposed research center will build around a core group of neuroscientists, pharmacologists and chemists at the University of New England (UNE) whose research is focused on understanding the neurobiology of pain. The COBRE will provide the junior investigators with a career development plan, mentorship, and research infrastructure that will facilitate gaining independent investigator status. Furthermore, new faculty recruitment is designed to strengthen our medicinal chemistry capabilities in collaboration with the College of Pharmacy. In building the chemistry group, the efforts in this COBRE are consistent with the concept of bringing innovative chemistry as a bridge between basic knowledge of pain and therapy. These efforts will provide Center scientists with novel compounds that can be used as valuable tools to explore the pathophysiology of chronic pain and ultimately may be advanced as clinical candidates in partnerships developed within the biopharmaceutical setting. Specific Aim 1 will increase the number of neuroscience investigators at UNE to create a critical mass of researchers necessary to sustain a vibrant and competitive research center. This Aim will be accomplished by fostering the pain related research programs of four current UNE junior faculty members who have not received R01 or comparable Research Project Grant support. In addition, we will recruit and hire an additional three investigators whose research programs will complement those of the existing faculty. Specific Aim 2 will expand neuroscience research infrastructure at UNE, providing access to core facilities that allow investigators to carry out cutting edge research on the neurobiological processes involved in the development of chronic pain. This Aim will be accomplished through the renovation of laboratory space, the purchase of core behavioral, imaging and histology equipment, and funding of key support personnel. Completion of these Aims will develop the research careers of a multidisciplinary group of junior investigators, and establish the core facilities and equipment necessary to constitute a competitive research center.

描述（由申请人提供）：尽管研究大大增加了我们对急性，炎症和神经性疼痛的基本机制的了解，但对于从急性到慢性PAI的过渡涉及的过程，相对较少了解。这种毛绒应用的目的是开发一个卓越的生物医学研究中心，该中心将有助于对慢性PIN和感觉功能的神经生物学的科学理解，从而促进新疗法的发现和开发。拟议的研究中心将围绕新英格兰大学（UNE）的神经科学家，药理学家和化学家的核心群体建立，他们的研究专注于理解疼痛的神经生物学。该鞋匠将为初级调查人员提供职业发展计划，指导和研究基础设施，以促进获得独立研究者的地位。此外，新的教师招聘旨在与药学院合作增强我们的药物化学能力。在建立化学群体时，这种鞋垫的努力与将创新化学作为疼痛和治疗基础知识之间的桥梁的概念一致。这些努力将为中心科学家提供新颖的化合物，可以用作探索慢性疼痛病理生理学的有价值的工具，并最终可以作为在生物制药环境中开发的伙伴关系中作为临床候选者进行前进。特定的目标1将增加UNE的神经科学研究人员的数量，以创建一大批维持充满活力和竞争性研究中心的研究人员。这个目标将通过培养尚未获得R01或可比研究项目赠款支持的四名UNE初级教师的疼痛研究计划来实现。此外，我们将招募并聘请另外三名研究人员，其研究计划将补充现有教师的研究计划。特定的目标2将扩大UNE的神经科学研究基础设施，从而访问核心设施，使研究人员能够对涉及慢性疼痛发展的神经生物学过程进行最先进的研究。这个目标将通过翻新实验室空间，购买核心行为，成像和组织学设备以及主要支持人员的资金来实现。这些目标的完成将发展一个多学科的初级研究人员小组的研究职业，并建立构成竞争性研究中心所需的核心设施和设备。