Depression Antidepressants and HIV infectivity

抑郁症 抗抑郁药和 HIV 感染

• 批准号: 8046414
• 负责人: DWIGHT L. EVANS
• 金额: $ 69.93万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-24 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8046414
• 关键词: AIDS/HIV problem; Address; Affect; Antidepressive Agents; Antiviral Agents; CCL3 gene; CCL4 gene; CCR5 gene; CD4 Antigens; CD8-Positive T-Lymphocytes; CD8B1 gene; CXCR4 gene; Cardiovascular Diseases; Cell physiology; Cells; Cellular Immunity; Clinical; Clinical Management; Clinical Research; Clinical Trials; Communicable Diseases; Coupled; Depressed mood; Diabetes Mellitus; Disease; Disease Progression; Exposure to; Glucocorticoids; HIV; HIV Infections; HIV Receptors; Immune; Individual; Investigation; Lymphocyte; Lymphocyte Function; Malignant Neoplasms; Measures; Mediating; Medical; Mental Depression; Morbidity - disease rate; Natural Immunity; Natural Killer Cells; Pathway interactions; Peripheral Blood Mononuclear Cell; Play; Population; Predisposition; Prospective Studies; Publishing; RANTES; Resolution; Risk Factors; Role; Selective Serotonin Reuptake Inhibitor; Series; Serotonin; Severities; Stress; System; T-Cell Receptor; T-Lymphocyte; TNF gene; Testing; Woman; World Health Organization; chemokine; chemokine receptor; cytokine; cytotoxicity; depressive symptoms; design; disability; disability-adjusted life years; epidemiology study; human disease; improved; macrophage; men; monocyte; mortality; public health relevance; receptor; receptor sensitivity; research study; response; restoration

DESCRIPTION (provided by applicant): The medical burden of depression is increasing and the World Health Organization projects that by the year 2020, depression will be the second leading cause of disability worldwide. An increasing number of studies have implicated depression as a potential risk factor in the morbidity and mortality for a wide range of human diseases, including HIV/AIDS. Although the underlying immune mechanisms by which depression influences HIV disease progression and mortality remain to be determined, considerable evidence suggests that killer lymphocytes play key roles in regulating HIV infection and are altered in depression. In our studies of individuals who are depressed, but otherwise medically healthy, we have found depression-associated decreases in natural killer (NK) cytolytic activity. In studies of HIV-infected individuals, we have shown that depression is associated with a reduction in NK cytolytic activity and an increase in HIV disease progression. We have recently demonstrated that resolution of depression is associated with restoration of NK cytotoxicity in HIV, and we have found that ex vivo treatment of lymphocytes with an SSRI enhances NK cytolytic activity. We have also observed that an SSRI and a glucocorticoid antagonist inhibit HIV infectivity of macrophages in HIV. The proposed study of depressed and non depressed, HIV- seronegative individuals is designed to test whether depression is associated with non-cytolytic, chemokine and cytokine, functional alterations of killer lymphocytes, as well as chemokine receptor sensitivity of macrophages and T-cells that are relevant to HIV-infectivity. We will study the role of serotonin and glucocorticoids (GCs) by comparing killer lymphocyte function in macrophage and T-cell HIV receptor response before and after exposure to an SSRI and a GC antagonist. Previous studies of depression and HIV have focused on cytolytic function of killer lymphocytes. A unique strength of the proposed study is the emphasis on the non-cytolytic functions and the effects of depression and anti-depressants on these factors which have HIV suppressive activity. Thus, the proposed study is designed to determine if depression increases the susceptibility to HIV-infectivity, to determine if anti-depressants decrease the susceptibility to HIV-infectivity, and to determine specific HIV suppressive factors that may underlie susceptibility to HIV-infectivity in depression. This study also may help determine if anti-depressant clinical trials are warranted in depressed HIV-infected individuals in order to enhance clinical management and improve morbidity and mortality of HIV infection. PUBLIC HEALTH RELEVANCE The medical burden of depression is increasing and the World Health Organization projects that by the year 2020, depression will be the second leading cause of disability worldwide. An increasing number of studies have implicated depression as a potential risk factor in the morbidity and mortality for a wide range of human diseases, including HIV/AIDS. The proposed study is designed to determine if depression increases the susceptibility to HIV-infectivity, to determine if anti-depressants decrease the susceptibility to HIV-infectivity, and to determine specific HIV suppressive factors that may underlie susceptibility to HIV-infectivity in depression.

描述（由申请人提供）：抑郁症的医疗负担正在增加，世界卫生组织预计，到 2020 年，抑郁症将成为全球第二大致残原因。越来越多的研究表明抑郁症是包括艾滋病毒/艾滋病在内的多种人类疾病发病和死亡的潜在危险因素。尽管抑郁症影响艾滋病毒疾病进展和死亡率的潜在免疫机制仍有待确定，但大量证据表明，杀伤淋巴细胞在调节艾滋病毒感染中发挥着关键作用，并在抑郁症中发生改变。在我们对抑郁但身体健康的个体的研究中，我们发现与抑郁相关的自然杀伤 (NK) 细胞溶解活性降低。在对 HIV 感染者的研究中，我们发现抑郁症与 NK 细胞溶解活性的降低和 HIV 疾病进展的增加有关。我们最近证明抑郁症的缓解与 HIV 中 NK 细胞毒性的恢复有关，并且我们发现用 SSRI 对淋巴细胞进行体外处理可增强 NK 细胞溶解活性。我们还观察到 SSRI 和糖皮质激素拮抗剂可抑制 HIV 巨噬细胞的 HIV 感染性。拟议的针对抑郁症和非抑郁症、HIV 血清阴性个体的研究旨在测试抑郁症是否与非细胞溶解性、趋化因子和细胞因子、杀伤淋巴细胞的功能改变以及巨噬细胞和 T 细胞的趋化因子受体敏感性有关。与 HIV 感染性有关。我们将通过比较暴露于 SSRI 和 GC 拮抗剂前后巨噬细胞中杀伤淋巴细胞的功能和 T 细胞 HIV 受体反应来研究血清素和糖皮质激素 (GC) 的作用。先前对抑郁症和艾滋病毒的研究主要集中在杀伤淋巴细胞的溶细胞功能上。本研究的独特优势是强调非细胞溶解功能以及抑郁症和抗抑郁药对这些具有 HIV 抑制活性的因素的影响。因此，拟议的研究旨在确定抑郁症是否会增加对艾滋病毒感染的易感性，确定抗抑郁药是否会降低对艾滋病毒感染的易感性，并确定可能导致抑郁症患者对艾滋病毒感染易感性的具体艾滋病毒抑制因素。这项研究还可能有助于确定是否有必要在抑郁的 HIV 感染者中进行抗抑郁临床试验，以加强临床管理并改善 HIV 感染的发病率和死亡率。 公共健康相关性 抑郁症的医疗负担正在增加，世界卫生组织预计，到 2020 年，抑郁症将成为全球第二大致残原因。越来越多的研究表明抑郁症是包括艾滋病毒/艾滋病在内的多种人类疾病发病和死亡的潜在危险因素。拟议的研究旨在确定抑郁症是否会增加对艾滋病毒感染的易感性，确定抗抑郁药是否会降低对艾滋病毒感染的易感性，并确定可能导致抑郁症患者对艾滋病毒感染易感性的具体艾滋病毒抑制因素。