Physical Activity in Anorexia Nervosa

神经性厌食症的体力活动

• 批准号: 8212228
• 负责人: B. TIMOTHY WALSH
• 金额: $ 39.61万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-10 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8212228
• 关键词: Animal Model; Anorexia Nervosa; Applications Grants; Behavior; Behavioral; Behavioral Research; Body Weight; Body Weight decreased; Body mass index; Clinical; Collaborations; Control Groups; Development; Devices; Disease; Eating Disorders; Economics; Energy Metabolism; Exercise; Functional disorder; Goals; Health; Hospitalization; Hospitals; Hyperactive behavior; Inpatients; Intercept; Lead; Measurement; Measures; Mental disorders; Metabolism; Modeling; Monitor; Motivation; Nature; Obesity; Outcome; Outpatients; Patients; Pharmacotherapy; Phenotype; Physical activity; Physiological; Play; Population; Prognostic Factor; Regulation; Relapse; Relative (related person); Research; Risk Factors; Role; Starvation; Time; Translating; Weight; Woman; Work; addiction; behavior measurement; effective therapy; improved; interest; novel; outcome forecast; reinforcer; restoration; sedentary

DESCRIPTION (provided by applicant): Anorexia Nervosa (AN) is a serious psychiatric illness for which prognostic factors remain unclear, no effective pharmacotherapy is established, and rates of relapse are high. Elevated levels of physical activity (PA) have long been noted in patients with AN and are considered by some a "fundamental feature of the disorder." Physical activity is known to play a critical role in other disorders of weight regulation and evidence suggests that high-level PA is a risk factor for relapse in some patients with AN. However, PA is often surprisingly overlooked in research on AN, possibly because it has been difficult to measure. There has been no systematic attempt to characterize the behavioral and motivational manifestations of PA in AN, and there has been no definitive assessment of the effect of PA on clinical outcome. These are critical questions for a disorder in which clarification of the phenotype(s), pathophysiology, and prognostic factors may prove essential to advancing its treatment. The overarching goals of this R01 grant proposal are to characterize PA and its role in the outcome of patients with AN. To do so we propose a comprehensive, multidimensional assessment employing cutting-edge approaches translated from two related fields of research. Specific Aims are to (1) Apply a novel device employed in metabolism research, the IDEEA, in conjunction with accelerometry, to characterize PA in AN qualitatively and quantitatively; and (2) Apply the Progressive Ratio (PR) task, used extensively in behavioral economics and addictions research, to quantify the reinforcing effect of exercise in patients with AN, and (3) Determine the ability of measures obtained under Aims 1 and 2 to predict one-year outcome following inpatient treatment with weight restoration for AN. Collaborators will include experts in research on metabolism and behavioral economics and addictions. Anticipated dividends of this work include identification of behavioral phenotype(s) of AN with distinct treatment needs, and of physiological and behavioral targets for such treatment. PUBLIC HEALTH RELEVANCE: Anorexia Nervosa is a serious psychiatric disorder of self-starvation, in which physical activity levels are sometimes extremely elevated. This proposed project will apply novel translational measurements to determine the nature of physical activity and its role in the outcome of Anorexia Nervosa. Results may improve our ability to predict prognosis in Anorexia Nervosa and may lead to development of more effective treatments for this disorder.

描述（由申请人提供）：神经性厌食症（AN）是一种严重的精神疾病，预后因素仍然不清楚，没有有效的药物治疗，并且复发率很高。长期以来，体育锻炼水平升高（PA）已在AN患者中注意到，并被某些“疾病的基本特征”视为。已知体育活动在体重调节的其他疾病中起着至关重要的作用，证据表明，高级PA是某些患者的复发危险因素。但是，PA在AN的研究中常常被忽略了，这可能是因为很难衡量。没有系统地尝试表征AN中PA的行为和动机表现，并且对PA对临床结果的影响没有确切的评估。这些是疾病的关键问题，在这种疾病中，澄清表型，病理生理学和预后因素可能对推进其治疗至关重要。该R01赠款提案的总体目标是表征PA及其在AN患者的结果中的作用。为此，我们提出了一种全面的，多维的评估，采用从两个相关研究领域翻译的尖端方法。具体目的是（1）应用代谢研究中采用的新型设备，IDEEA结合加速度计，以定性和定量地表征PA； （2）应用在行为经济学和成瘾研究中广泛使用的渐进比率（PR）任务，以量化AN患者的运动的增强作用，以及（3）确定AIM 1和2下的措施能够预测重量恢复患者治疗后一年的结果。合作者将包括有关代谢和行为经济学和成瘾研究的专家。这项工作的预期股息包括鉴定有不同治疗需求的行为表型，以及这种治疗的生理和行为靶标。公共卫生相关性：神经性厌食症是一种严重的自我饥饿精神病，其中体育活动水平有时极高地升高。该提出的项目将采用新颖的翻译测量值来确定身体活动的性质及其在神经性厌食症的结果中的作用。结果可能会提高我们预测神经性厌食症预后的能力，并可能导致对这种疾病的更有效治疗的发展。