Translational Research on Eating Disorders

饮食失调的转化研究

• 批准号: 6446831
• 负责人: B. TIMOTHY WALSH
• 金额: $ 52.47万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6446831
• 关键词: adult human (21+); anorexia nervosa; avoidance behavior; behavioral /social science research tag; bulimia nervosa; dietary control; disease /disorder model; eating; eating disorders; ethology; exercise; female; human subject; interdisciplinary collaboration; laboratory rat; neurochemistry; nutrition related tag; patient oriented research; psychobiology; reinforcer; satiations; stimulus /response; substance abuse related behavior; taste; women's health

DESCRIPTION (provided by applicant): The eating disorders, Anorexia Nervosa and Bulimia Nervosa, are psychiatric illnesses of uncertain etiology which affect a significant number of women and which are associated with substantial morbidity and mortality. A central behavioral feature of these disorders is a disturbance in the control of meal size. Anorexia Nervosa is characterized by abnormally small meals and Bulimia Nervosa by abnormally large ("binge") meals. Substantial progress has been made in the last two decades in understanding the controls of meal size in laboratory animals, but direct applications of these models to disordered eating are lacking. A second clinical characteristic of eating disorders is a narrowing of behavioral repertoire so that food-related thinking and behavior progressively interfere with other occupational and social activities. This pattern is reminiscent of the behavior of individuals dependent on drugs. There are substantial preclinical data documenting the behavioral and neurochemical effects of drugs of abuse, but, again, there have been few attempts to examine systematically the utility of this information in understanding eating disorders. This proposed R21 Developmental Grant will translate preclinical knowledge of the controls of eating behavior and of substance use to the study of human eating disorders. A formal collaboration will be established between investigators with expertise in the study of feeding behavior in animals, investigators with expertise in the study of human substance abuse and investigators with expertise in the study of human eating and eating disorders. This research group will develop and conduct experiments to translate basic animal research into the study of human eating disorders and, conversely, to examine in animal models phenomena described in clinical experience with patients with eating disorders.

描述（由申请人提供）：饮食失调，神经性厌食症和 神经性贪食症，是不确定病因的精神病，影响了 大量妇女，与大量发病有关 和死亡率。这些疾病的主要行为特征是干扰 在控制餐大小的情况下。神经性厌食症的特征是异常 小餐和神经性贪食症神经异常（“暴饮”）餐。 在过去的二十年中，已经取得了重大进展，以理解 控制实验动物的餐大小，但直接应用这些 缺乏饮食不当的模型。第二个临床特征 饮食失调是行为曲目的缩小，因此与食物有关 思维和行为逐渐干扰其他职业和 社交活动。这种模式让人想起个体的行为 取决于药物。有大量的临床前数据记录 滥用药物的行为和神经化学作用，但又有 很少尝试系统地检查此信息的实用性 了解饮食失调。 提出的R21发展赠款将转化有关的临床前知识 饮食行为的控制和对人类研究的物质使用的控制 饮食失调。将建立正式合作 在研究动物喂养行为方面具有专业知识的研究人员， 研究人员在研究人类药物滥用和研究方面具有专业知识 研究人员在研究人类饮食和饮食失调方面具有专业知识。 该研究小组将开发和进行实验以翻译基本 动物研究人类饮食失调的研究，相反 在动物模型中检查的现象在临床经验中描述 饮食失调的患者。