NOVEL STRATEGIES FOR OVARIAN CANCER PREVENTION

预防卵巢癌的新策略

• 批准号: 8173310
• 负责人: Jay W Wright
• 金额: $ 5.71万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173310
• 关键词: Affect; Age; Animals; Biological Factors; Cells; Computer Retrieval of Information on Scientific Projects Database; Detergents; Development; Disease; Epithelial; Epithelium; Etiology; Excision; Failure; Family history of; Funding; Gene Expression; Grant; Institution; Macaca mulatta; Malignant neoplasm of ovary; Methods; Modeling; Ovarian; Prevention strategy; Research; Research Personnel; Resources; Risk; Risk Factors; Source; Surface; System; Testing; United States National Institutes of Health; Woman; anticancer research; cancer risk; nonhuman primate; novel strategies; ovarian cancer prevention; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Advances in ovarian cancer research are limited by a failure to understand the etiology of the disease. In large part this is due to the absence of a natural model for epithelial ovarian cancerthe predominant form affecting womenand an inability for most animal systems to accurately reflect the normal biological factors that have been associated with ovarian cancer risk (namely age and ovarian function). As a result, the development of preventive strategies is limited by an inability to identify appropriate risk factors. We have utilized gene expression studies to identify changes in gene expression found in cultured ovarian cells from women with versus without a family history of the disease, and the rhesus model will be used to evaluate methods of altering gene expression in these "at risk" cells as a means to prevent ovarian cancer in women with a family history of the disease. In addition, we will use the nonhuman primate as a model to test whether the source of most ovarian cancers, the ovarian surface epithelium, may be eliminated using mild detergent to permanently reduce ovarian cancer risk. Current studies indicate that the surface epithelium does not regrow within 6 months of removal via deteregent.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 由于未能了解该疾病的病因，卵巢癌研究的进展受到限制。 这在很大程度上是由于上皮性卵巢癌（影响女性的主要形式）缺乏自然模型，并且大多数动物系统无法准确反映与卵巢癌风险相关的正常生物因素（即年龄和年龄）。卵巢功能）。 因此，预防策略的制定因无法识别适当的风险因素而受到限制。 我们利用基因表达研究来鉴定有和没有该疾病家族史的女性的培养卵巢细胞中发现的基因表达变化，并且恒河猴模型将用于评估改变这些“危险”细胞中基因表达的方法作为预防有卵巢癌家族史的女性的一种手段。 此外，我们将使用非人类灵长类动物作为模型，测试是否可以使用温和的清洁剂消除大多数卵巢癌的来源——卵巢表面上皮，从而永久降低卵巢癌风险。 目前的研究表明，表面上皮在通过清洁剂去除后 6 个月内不会重新生长。