DTS Imaging with a Digitally Addressable X-Ray Source (DAXS)

使用数字可寻址 X 射线源 (DAXS) 进行 DTS 成像

• 批准号: 8454505
• 负责人: CHRIS C SHAW
• 金额: $ 51.17万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8454505
• 关键词: 4D Imaging; Algorithms; Anatomy; Anodes; Area; Cancer Center; Collaborations; Development; Devices; Dimensions; Documentation; Electronics; Electrons; Equilibrium; Equipment; Evaluation; Generations; Goals; Image; Imaging Techniques; Individual; Industry Collaboration; Injection of therapeutic agent; Laboratory Research; Location; Metric; Monitor; Motion; Pattern; Performance; Physiologic pulse; Principal Investigator; Research; Roentgen Rays; Safety; Scanning; Site; Source; Speed; Spottings; System; Systems Integration; Techniques; Technology; Test Result; Testing; Texas; Three-Dimensional Image; Vacuum; abstracting; austin; base; computerized; design; design and construction; digital; digital imaging; evaluation/testing; imaging detector; operation; prototype; public health relevance; research clinical testing; research study; seal; tool; voltage

DESCRIPTION (provided by applicant): DTS imaging with a Digitally Addressable X-ray Source (DAXS) Abstract 4-D x-ray imaging would provide a powerful tool for imaging procedures involving contrast injection or anatomical motions. In this research, we propose to develop and investigate a 4-D x-ray imaging system based on digital tomosynthesis (DTS) and a digitally addressable x-ray source (DAXS). The DAXS allows x-rays to be generated at any digitally selected location on a flat x-ray panel. This would enable us to design and construct a stationary DTS system that contains no moving parts. Due to the elimination of physically moving parts, the scan speed can be substantially increased, thus allowing for 4-D imaging, with which 3-D images of moving anatomy or injected contrast materials can be imaged and monitored. The use of a DAXS also allows the x-ray source to be digitally shifted with a 2-D pattern, leading to more effective blurring of the out of focal plane objects and better contrast of the in plane objects. The proposed research consists of two major parts carried out at two different sites: Stellarray Inc., a subsidiary of Stellar Micro Devices, Inc. (SMD) at Austin, TX and the Digital Imaging Research Laboratory (DIRL) at the U. of Texas M. D. Anderson Cancer Center (MDACC) at Houston, TX. The closeness of the two sites encourages active collaboration and interaction. In this Academic-Industry collaboration, the DAXS technology will be developed at SMD and provided to MDACC-DIRL to implement and investigate the DTS techniques for 4-D imaging. Operation parameters and image quality metrics will be investigated and optimized. Phantom experiments will be performed to demonstrate and validate the proposed 4-D x-ray imaging techniques. In this collaboration, there will be a separate Principal Investigator (PI) at each site. The MDACC PI will also serve as the contact and coordinating PI.

描述（由申请人提供）：具有数字可寻址X射线源（DAXS）抽象4-D X射线成像的DTS成像将为涉及对比度注入或解剖学运动的成像过程提供强大的工具。在这项研究中，我们建议开发和研究基于数字间隔（DTS）和数字可寻址的X射线源（DAXS）的4-D X射线成像系统。 DAX允许在平面X射线面板上的任何数字选择位置生成X射线。这将使我们能够设计和构建一个不包含活动部件的固定DTS系统。由于消除了物理运动部位，可以大大提高扫描速度，从而允许4-D成像，可以对3-D进行解剖或注入造影剂的3-D图像进行成像和监测。 DAX的使用还允许以2-D模式将X射线源进行数字移动，从而导致焦平面对象的更有效模糊，并且在平面对象中更好地对比度。拟议的研究包括在两个不同地点进行的两个主要部分：Stellarray Inc.，这是德克萨斯州奥斯汀市的Stellar Micro Decession，Inc。（SMD）的子公司和德克萨斯州M. D. Anderson癌症中心（MDACC）的德克萨斯州奥斯汀市的数字成像研究实验室（DIRL）。这两个站点的亲密关系鼓励了积极的协作和互动。在这项学术行业合作中，DAXS技术将在SMD上开发，并向MDACC-DIRL提供实施和调查4D成像的DTS技术。将研究和优化操作参数和图像质量指标。将进行幻影实验，以证明和验证所提出的4-D X射线成像技术。在此合作中，每个站点将有一个单独的主要研究员（PI）。 MDACC PI还将用作接触和协调PI。