A Dual Resolution Cone Beam CT System for 3-D Breast Imaging

用于 3D 乳腺成像的双分辨率锥形束 CT 系统

• 批准号: 7689485
• 负责人: CHRIS C SHAW
• 金额: $ 45.02万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7689485
• 关键词: 3-Dimensional; Anatomy; Area; Breast; Collimator; Computer Simulation; Contrast Sensitivity; Coupled; Couples; Development; Diagnosis; Dose; Height; Image; Image Guided Biopsy; Imaging Techniques; Investigation; Lesion; Mammography; Modality; Nature; Needles; Operative Surgical Procedures; Patients; Performance; Phase; Positioning Attribute; Procedures; Resolution; Retinal Cone; Scanning; Screening procedure; System; Techniques; Time; Title; Width; base; calcification; clinical application; cone-beam computed tomography; detector; improved; interest; malignant breast neoplasm; novel strategies; prototype; reconstruction; research study; tool

DESCRIPTION (provided by applicant: Despite the development of new imaging modalities, x-ray mammography remains the main tool for screening, diagnosis and management of breast cancers. However, the limited sensitivity and superimposition of calcifications and masses on the breast parenchyma have compromised its value in these procedures. Recent development of flat panel (FP) based cone beam CT (CBCT) techniques have initiated a new approach referred to as the dedicated or pendant geometry cone beam breast CT technique which couples high contrast sensitivity with true 3-D rendition of breast anatomy and lesions. However, although the spatial resolution offered by FP based CBCT is potentially higher than those provided by the conventional CT techniques, it is still significantly lower than those of mammographic imaging techniques as required for detecting and visualizing small calcifications. In this project, we propose to develop, investigate and evaluate a new technique referred to as the dual-resolution CBCT (DRCBCT) technique to allow the spatial resolution of the 3D breast images to be improved beyond those achievable with FPCBCT. With this technique, a FP detector is used to acquire full field CBCT images which are used to select a volume-of-interest (VOI). The breast is then re-positioned to have the VOI centered to the iso-center. A collimator is added to limit the x-ray field to the VOI and a small field of view CCD detector is used to acquire high resolution projection images for the VOI at an appropriate exposure level. Limited height, full width FP images are then obtained by re- scanning or by computing the re-projections from previously obtained FPCBCT images to fill in the truncated area as required for high resolution VOI CBCT. Because high resolution image acquisition and reconstruction are limited to the VOI, both patient dose and computation time can be kept at a reasonable level, making it more practical to implement and use for clinical applications. In the R21 phase (Year 1), we propose to investigate and demonstrate the feasibility of the dual resolution CBCT technique with computer simulation and bench top imaging experiments. In the R33 phase (Years 2, 3 and 4), we propose to construct, optimize and investigate a prototype system for dual resolution CBCT. Both phantom and patient images will be obtained to demonstrate the performance improvement by the dual resolution CBCT techniques and potential applications in the diagnosis and management of breast cancers. Successful development and investigation of the dual resolution CBCT technique may provide a powerful tool for 3-D breast imaging. The addition of high resolution capability, coupled with improved contrast sensitivity and the true 3-D nature of breast CT images may allow the dual resolution CBCT technique to replace and even surpass conventional mammography for improved diagnosis and management of breast cancers, including image guided biopsy, surgical planning, and needle localization. Proposal to be submitted to the NIH-NCI as R21/R33 project Title A Dual Resolution Cone Beam CT System for 3-D Breast Imaging Project Narrative Despite the development of new imaging modalities, x-ray mammography remains the main tool for screening, diagnosis and management of breast cancers. However, the limited sensitivity and superimposition of calcifications and masses on the breast parenchyma have compromised its value in these procedures. Recent development of flat panel (FP) based cone beam CT (CBCT) techniques have intitiated a new approach referred to as the dedicated or pendant geometry cone beam breast CT technique which couples high contrast senstivity with true 3-D rendition of breast anatomy and lesions. However, although the spatial resolution offered by FP based CBCT is potentially higher than those provided by the conventional CT techniques, it is still significantly lower than those of mammographic imaging techniques as required for detecting and visualizing small calcifications. In this project, we propose to develop, investigate and evaluate a new technique referred to as the dual-resolution CBCT (DRCBCT) technique to allow the spatial resolution of the 3D breast images to be improved beyond those achievable with FPCBCT. With this technique, a FP detector is used to acquire full field CBCT images which are used to select a volume-of-interest (VOI). The breast is then re-positioned to have the VOI centered to the iso-center. A collimator is added to limit the x-ray field to the VOI and a small field of view CCD detector is used to acquire high resolution projection images for the VOI at an appropriate exposure level. Limited height, full width FP images are then obtained by re- scanning or by computing the re-projections from previously obtained FPCBCT images to fill in the truncated area as required for high resolution VOI CBCT. Because high resolution image acquisition and reconstruction are limited to the VOI, both patient dose and computation time can be kept at a reasonable level, making it more practical to implement and use for clinical applications. In the R21 phase (Year 1), we propose to investigate and demonstrate the feasibility of the dual resolution CBCT technique with computer simulation and bench top imaging experiments. In the R33 phase (Years 2, 3 and 4), we propose to construct, optimize and investigate a prototype system for dual resolution CBCT. Both phantom and patient images will be obtained to demonstrate the performance improvement by the dual resolution CBCT techniques and potential applications in the diagnosis and management of breast cancers. Successful development and investigation of the dual resolution CBCT technique may provide a powerful tool for 3-D breast imaging. The addition of high resolution capability, coupled with improved contrast sensitivity and the true 3-D nature of breast CT images may allow the dual resolution CBCT technique to replace and even surpass conventional mammography for improved diagnosis and management of breast cancers, including image guided biopsy, surgical planning, and needle localization.

描述（由申请人提供：尽管发展了新的成像方式，但X射线乳房X线摄影仍然是筛查，诊断和管理乳腺癌的主要工具。但是，在乳房实质上对钙化和质量的敏感性和叠加有限，在这些过程中损害了其在这些过程中的价值。该程序的最新介绍了基于平面式（FP）的开发。侧面的几何锥乳房CT技术与乳房解剖结构和病变的真实3-D呈现，尽管基于FP的CBCT提供的空间分辨率可能高于常规CT技术，但它仍比传统的CT技术更低。并评估一种称为双分辨率CBCT（DRCBCT）技术的新技术，以使3D乳房图像的空间分辨率超出了FPCBCT可实现的空间分辨率。使用此技术，使用FP检测器来获取用于选择利益量（VOI）的全场CBCT图像。然后将乳房重新定位以使VOI以ISO中心为中心。添加了一个准直仪以将X射线字段限制在VOI中，并且使用一个小的视野CCD检测器用于在适当的曝光水平下为VOI获取高分辨率投影图像。然后，通过重新扫描或计算先前获得的FPCBCT图像的重新投影以根据高分辨率VOI CBCT的要求填充截短区域，从而获得有限的高度，全宽FP图像。由于高分辨率的图像采集和重建仅限于VOI，因此患者剂量和计算时间都可以保持在合理的水平上，从而使实施和用于临床应用更为实用。在R21阶段（第1年）中，我们建议通过计算机模拟和台式TOP成像实验研究并证明双重分辨率CBCT技术的可行性。在R33阶段（第2、3和4年）中，我们建议构建，优化和研究双重分辨率CBCT的原型系统。将获得幻影和患者图像，以证明双重分辨率CBCT技术以及在乳腺癌的诊断和管理中的潜在应用。双重分辨率CBCT技术的成功开发和研究可能为3D乳房成像提供强大的工具。添加高分辨率能力，再加上提高的对比度灵敏度以及乳房CT图像的真实3-D性质，可以使双分辨率CBCT技术更换甚至超过常规乳房X线摄影，以改善对乳腺癌的诊断和管理，包括图像指导性活检，外科手术计划和针头定位。提出的提议将作为R21/R33项目标题提交给NIH-NCI，尽管有新成像方式发展，但用于3-D乳房成像项目叙事的双分辨率锥束CT系统，X射线乳房X线摄影仍然是筛查乳腺癌的筛查，诊断和管理的主要工具。然而，乳腺实质对钙化和质量的敏感性和叠加有限，在这些过程中损害了其价值。基于平板面板（FP）的锥束CT（CBCT）技术的最新开发已将一种新方法注入，称为专用或吊坠几何形状锥束乳腺CT技术，该技术将高对比度的senstivity与真正的3D乳房解剖和乳房解剖和病变结合在一起。但是，尽管基于FP的CBCT提供的空间分辨率可能高于常规CT技术提供的空间分辨率，但它仍然明显低于检测和可视化小钙化所需的乳房X线摄影技术。在这个项目中，我们建议开发，调查和评估一种新技术，称为双分辨率CBCT（DRCBCT）技术，以允许将3D乳房图像的空间分辨率改进，远远超出了FPCBCT可实现的空间分辨率。使用此技术，使用FP检测器来获取用于选择利益量（VOI）的全场CBCT图像。然后将乳房重新定位以使VOI以ISO中心为中心。添加了一个准直仪以将X射线字段限制在VOI中，并且使用一个小的视野CCD检测器用于在适当的曝光水平下为VOI获取高分辨率投影图像。然后，通过重新扫描或计算先前获得的FPCBCT图像的重新投影以根据高分辨率VOI CBCT的要求填充截短区域，从而获得有限的高度，全宽FP图像。由于高分辨率的图像采集和重建仅限于VOI，因此患者剂量和计算时间都可以保持在合理的水平上，从而使实施和用于临床应用更为实用。在R21阶段（第1年）中，我们建议通过计算机模拟和台式TOP成像实验研究并证明双重分辨率CBCT技术的可行性。在R33阶段（第2、3和4年）中，我们建议构建，优化和研究双重分辨率CBCT的原型系统。将获得幻影和患者图像，以证明双重分辨率CBCT技术以及在乳腺癌的诊断和管理中的潜在应用。双重分辨率CBCT技术的成功开发和研究可能为3D乳房成像提供强大的工具。添加高分辨率能力，再加上提高的对比度灵敏度以及乳房CT图像的真实3-D性质，可以使双分辨率CBCT技术更换甚至超过常规乳房X线摄影，以改善对乳腺癌的诊断和管理，包括图像指导性活检，外科手术计划和针头定位。