Optimized Digital Mammography with an a-Se FP Imager

使用 a-Se FP 成像仪优化数字乳房 X 线摄影

• 批准号: 7240452
• 负责人: CHRIS C SHAW
• 金额: $ 58.57万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7240452
• 关键词: Appearance; Area; Breast Cancer Early Detection; Breast Microcalcification; Clinical; Collimator; Condition; Data; Detection; Diagnosis; Diagnostic; Digital Mammography; Disadvantaged; Dose; Electronics; Feedback; Film; Financial compensation; Goals; Image; Image Enhancement; Imagery; Imaging Phantoms; Imaging Techniques; Lead; Life; Longevity; Magnetic Resonance; Magnetic Resonance Imaging; Mammary Gland Parenchyma; Mammography; Measurement; Measures; Motivation; Noise; North America; Pattern; Perception; Performance; Process; Property; Research; Research Personnel; Resolution; Scanning; Scheme; Screening procedure; Selenium; Signal Transduction; Silicon; Simulate; Structure; System; Techniques; Testing; Tissues; Transistors; Ultrasonography; United States; Width; Woman; Women' s Health; attenuation; base; breast cancer diagnosis; design; design and construction; desire; detector; digital; digital imaging; image processing; improved; malignant breast neoplasm; models and simulation; novel; optical imaging; programs; quantum; size; soft tissue; tool; transmission process

DESCRIPTION (provided by applicant): Breast cancer has been recognized as a major threat to women's health and longevity particularly in North America. one of 9 women in the United States may be diagnosed to have breast cancer in her lifetime. Despite advances of ultrasound, magnetic resonance and optical imaging techniques, x-ray mammography remains the main tool for early detection of breast cancer and subsequent diagnostic workup. It is therefore of great importance to improve the x-ray mammography techniques to optimize the detection and diagnosis of breast cancer. With a desire to improve image quality and image management, there has been a strong motivation to shift from the conventional screen/film techniques to digital image acquisition techniques. Several digital mamrnography techniques have been developed and commercialized. Each of these techniques may have advantages in some aspects and drawbacks in others. The goals of this research are to optimize and investigate a digital mammography technique to improve the quality and utilization of the resulting digital mammograms. To achieve these goals, we will design, construct and investigate a Scanning Equalization Digital Mammography (SEDM) system using an amorphous selenium and amorphous silicon thin film transistor (aSe/aSi TFT) array based flat-panel imager as the x-ray detector. Slot scanning with regionally modulated beam width will be used to achieve both scatter rejection and exposure equalization. A novel image readout technique will be implemented and investigated to allow for electronic aft-collimation. A re-scaling technique will be implemented and tested to generate digital mammography images with appearance similar to that of a regular mammogram but with improved contrast-tonoise ratios (CNRs), equalized signal-to-noise ratios (SNRs) and enabling accurate transmission measurement. We will evaluate and investigate the proposed SEDM system with physical measurements and observers' performance studies based on phantom images designed to mimic clinical mammograms. The proposed system is expected to result in improved detection and visualization of microcalcifications and masses and better utilization of image data in both screening and diagnostic mammography. This is achieved through: (1) improved modulation transfer function (MTF) and detective quantum efficiency (DQE) with an aSe/aSi TFT based FP detector, (2) an approximately twofold increase of the detector exposure with similar or even better scatter rejection as compared to the anti-scatter grid technique, (3) a redistribution of x-ray fluence from highly transmitted areas to dense tissue regions (exposure equalization) to achieve more uniform image SNRs, and (4) provision of nearly scatterfree image data with equalized SNRs for better image processing, analysis and quantitative studies.

描述（由申请人提供）： 乳腺癌被认为是对妇女健康和寿命的主要威胁，尤其是在北美。美国的9名妇女中的一名可能被诊断出她的一生中患有乳腺癌。尽管有超声，磁共振和光学成像技术的进步，但X射线乳房摄影仍然是早期检测乳腺癌和随后的诊断工作的主要工具。因此，提高X射线乳房X线摄影技术以优化乳腺癌的检测和诊断非常重要。渴望提高图像质量和图像管理，从传统的屏幕/胶片技术转变为数字图像采集技术已经有很大的动力。已经开发和商业化了几种数字Mamrnography技术。这些技术中的每一个都可能在某些方面和其他方面具有优势。这项研究的目标是优化和研究数字乳腺X线摄影技术，以提高所得数字乳房X线照片的质量和利用。 为了实现这些目标，我们将使用基于X射线检测器的基于X射线检测器的无定形硒和无定形硅薄膜晶体管（ASE/ASI TFT）阵列晶体管（ASE/ASI TFT）阵列晶体管（ASE/ASI TFT）阵列晶体晶体管（ASE/ASI TFT）阵列晶体晶体管（ASE/ASI TFT）阵列。具有区域调制的梁宽度的插槽扫描将用于实现散射排斥和暴露均衡。将实施和研究一种新型的图像读数技术，以允许电子船尾碰撞。将实施和测试一种重新缩放技术，以生成具有类似于常规乳房X线照片的数字乳房X线摄影图像，但具有改善的对比度比率（CNRS），均衡的信号 - 噪声比（SNRS）并实现准确的传播测量值。我们将根据旨在模仿临床乳房X线照片的幻像图像进行物理测量和观察者的性能研究评估和研究所提出的SEDM系统。 预计该提出的系统将改善对微钙化和质量的检测和可视化，并在筛查和诊断乳房X线摄影中更好地利用图像数据。通过：（1）改善基于ASE/ASI TFT FP检测器的调节转移函数（MTF）和侦探量子效率（DQE），（（2）与抗片段网格技术相比，（3）X射线均衡均衡的均衡均衡区域相似甚至更好的散射拒绝，探测器暴露的散布拒绝大约增加了两倍，（3）为了获得更均匀的图像SNR，（4）提供具有均衡SNR的几乎无散射图像数据，以更好地处理图像处理，分析和定量研究。

项目成果

Dual-energy digital mammography for calcification imaging: noise reduction techniques.

• DOI: 10.1088/0031-9155/53/19/010
• 发表时间: 2008-10-07
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Kappadath SC;Shaw CC
• 通讯作者: Shaw CC

Comparison of full-field digital mammography and screen-film mammography for detection and characterization of simulated small masses.

全视野数字乳房 X 线摄影和屏幕胶片乳房 X 线摄影对模拟小肿块的检测和表征的比较。

• DOI: 10.2214/ajr.05.0126
• 发表时间: 2006
• 期刊: AJR. American journal of roentgenology
• 作者: Yang,WeiT;Lai,Chao-Jen;Whitman,GaryJ;MurphyJr,WilliamA;Dryden,MarkJ;Kushwaha,AnneC;Sahin,AysegulA;Johnston,Dennis;Dempsey,PeterJ;Shaw,ChrisC
• 通讯作者: Shaw,ChrisC