Light-activated Electronic p-Chips for Tagging Samples in Biorepositories and Cry

用于标记生物样本库和 Cry 中样本的光激活电子 p 芯片

• 批准号: 8719366
• 负责人: WLODEK MANDECKI
• 金额: $ 51.38万
• 依托单位: PHARMASEQ, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-20 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8719366
• 关键词: Adhesions; Adhesives; Bar Codes; Biological; Biomedical Research; Cells; Communities; Computer software; Contracts; Crying; Databases; Devices; Electronics; Evaluation; Failure; Feedback; Freezing; Goals; Human Resources; Ice; Institution; Label; Laboratories; Lasers; Light; Link; Liquid substance; Manufacturer Name; Medical Research; Methodology; Methods; Nitrogen; Optics; Performance; Phase; Play; Positioning Attribute; Procedures; Process; Protocols documentation; Reader; Reading; Research Personnel; Role; Sampling; Silicon; Silicon Dioxide; Site; Solutions; Surface; System; Techniques; Technology; Temperature; Testing; Time; Tissues; Tube; Validation; Vial device; Work; Writing; base; biobank; biological research; cold temperature; comparative; cost; cost effective; design; design and construction; digital; extreme temperature; improved; operation; prototype; software development; validation studies

DESCRIPTION (provided by applicant): The purpose of the present project is to implement a new RFID tagging system for rapid identification of vials in biorepositories. It is based on the PharmaSeq laser light- activated microtransponder, which is also known as a p-Chip. Its main advantages are its small size, low cost, inertness (silica-based), and durability under extremes of temperature. P-Chips have been shown to be viable and easy to read under conditions, such as the presence of frost, where traditional bar code labels fail due to problems related to interference or adhesive failure. Determining the serial ID numbers of p-Chips imbedded in the walls of vials is done with a dedicated reader that can be configured in several ways. The software associates a particular vial ID with a database to determine the provenance of the sample. Reading is extremely rapid giving the opportunity to maintain (or be close to) the storage temperature during polling. The main goals of this project are to: (1) design and optimize the process for embedding p-Chips in one or more types of sample vials for use at varying storage temperatures; (2) modify the existing p-Chip/reader system for use with vials, including designing and implementing bench-top readers that can either poll single vials or entire racks of vials; (3) improve key features of the p-Chips themselves for very low temperature conditions; (4) provide software routines that are compatible with existing enterprise systems for biorepositories; and (5) to validate the system with several collaborators. Successful completion of this work will result in a method and standard operating procedures that will improve sample storage techniques and provide more reliable samples to the biomedical research community.

描述（由申请人提供）：本项目的目的是实施一种新的 RFID 标签系统，用于快速识别生物样本库中的小瓶。它基于 PharmaSeq 激光激活微应答器，也称为 p-Chip。其主要优点是尺寸小、成本低、惰性（基于二氧化硅）和极端温度下的耐久性。 P-Chips 已被证明在霜冻等条件下可行且易于读取，在霜冻条件下，传统条形码标签会因干扰或粘合失效相关问题而失效。确定嵌入小瓶​​壁中的 p-Chips 的序列 ID 号是通过专用读取器完成的，该读取器可以通过多种方式进行配置。该软件将特定的样品瓶 ID 与数据库关联起来，以确定样品的来源。读取速度非常快，可以在轮询期间保持（或接近）存储温度。该项目的主要目标是： (1) 设计和优化将 p-Chips 嵌入一种或多种类型的样品瓶中以在不同储存温度下使用的过程； (2) 修改现有的 p-Chip/读取器系统以用于小瓶，包括设计和实施可以轮询单个小瓶或整个小瓶架的台式读取器； (3) 改进 p-Chips 本身在极低温度条件下的关键特性； (4) 提供与生物样本库现有企业系统兼容的软件例程； (5) 与多个合作者一起验证系统。这项工作的成功完成将产生一种方法和标准操作程序，从而改进样品存储技术并为生物医学研究界提供更可靠的样品。