Light-activated Electronic p-Chips for Tagging Samples in Biorepositories and Cry

用于标记生物样本库和 Cry 中样本的光激活电子 p 芯片

• 批准号: 8312866
• 负责人: WLODEK MANDECKI
• 金额: $ 30万
• 依托单位: PHARMASEQ, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-20 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8312866
• 关键词: Adhesions; Adhesives; Bar Codes; Biological; Biomedical Research; Cells; Communities; Computer software; Contracts; Crying; Databases; Devices; Electronics; Evaluation; Failure; Feedback; Freezing; Goals; Human Resources; Ice; Institution; Label; Laboratories; Lasers; Light; Link; Liquid substance; Manufacturer Name; Medical Research; Methodology; Methods; Nitrogen; Optics; Performance; Phase; Play; Positioning Attribute; Procedures; Process; Protocols documentation; Reader; Reading; Research Personnel; Role; Sampling; Silicon; Silicon Dioxide; Site; Solutions; Surface; System; Techniques; Technology; Temperature; Testing; Time; Tissues; Tube; Validation; Vial device; Work; Writing; base; biobank; biological research; cold temperature; comparative; cost; cost effective; design; design and construction; digital; extreme temperature; improved; operation; prototype; software development; validation studies

DESCRIPTION (provided by applicant): The purpose of the present project is to implement a new RFID tagging system for rapid identification of vials in biorepositories. It is based on the PharmaSeq laser light- activated microtransponder, which is also known as a p-Chip. Its main advantages are its small size, low cost, inertness (silica-based), and durability under extremes of temperature. P-Chips have been shown to be viable and easy to read under conditions, such as the presence of frost, where traditional bar code labels fail due to problems related to interference or adhesive failure. Determining the serial ID numbers of p-Chips imbedded in the walls of vials is done with a dedicated reader that can be configured in several ways. The software associates a particular vial ID with a database to determine the provenance of the sample. Reading is extremely rapid giving the opportunity to maintain (or be close to) the storage temperature during polling. The main goals of this project are to: (1) design and optimize the process for embedding p-Chips in one or more types of sample vials for use at varying storage temperatures; (2) modify the existing p-Chip/reader system for use with vials, including designing and implementing bench-top readers that can either poll single vials or entire racks of vials; (3) improve key features of the p-Chips themselves for very low temperature conditions; (4) provide software routines that are compatible with existing enterprise systems for biorepositories; and (5) to validate the system with several collaborators. Successful completion of this work will result in a method and standard operating procedures that will improve sample storage techniques and provide more reliable samples to the biomedical research community. PUBLIC HEALTH RELEVANCE: Biorepositories play an important role in basic and applied biological and medical research. A key issue for many researchers is the availability of high quality tissue, cell, and other types of samples whose identify is well characterized, and not compromised. The new electronic identification system has the potential to greatly increase the use of RFID technology in sample storage and to help to maintain sample identity and integrity.

描述（由申请人提供）：本项目的目的是实施一个新的RFID标记系统，以快速识别生物库中的小瓶。它基于Pharmaseq Laser光激活的微转带，该微转带器也称为P-Chip。它的主要优点是其尺寸很小，低成本，惰性（基于二氧化硅）以及在极端温度下的耐用性。 P-CHIP已被证明是可行的，易于阅读的条件，例如Frost的存在，在霜冻的存在下，由于与干扰或粘合剂失败有关的问题，传统条形码标签失败了。确定嵌入在小瓶墙壁的p-chip的序列ID号是由可以通过多种方式配置的专用读取器完成的。该软件将特定的小瓶ID与数据库相关联，以确定样本的出处。阅读非常迅速，使得在轮询过程中保持（或接近）存储温度的机会。该项目的主要目标是：（1）设计和优化将P-CHIP嵌入一种或多种类型的样品小瓶中的过程，以在不同的存储温度下使用； （2）修改现有的p-chip/读取器系统以与小瓶一起使用，包括设计和实施台式读取器，这些台式读取器可以轮询单小瓶或整个小瓶架； （3）在非常低的温度条件下，提高了P-CHIP自己的关键特征； （4）提供与现有的生物局企业系统兼容的软件例程； （5）用几个合作者验证系统。这项工作的成功完成将导致一种方法和标准操作程序，该方法将改善样品存储技术，并为生物医学研究界提供更可靠的样本。 公共卫生相关性：生物局体在基础和应用生物学和医学研究中起着重要作用。对于许多研究人员来说，一个关键问题是高质量的组织，细胞和其他类型的样品的可用性，而这些样品的识别表征得很好且不妥协。新的电子识别系统有可能大大增加RFID技术在样品存储中的使用，并有助于维持样本身份和完整性。