Enhancing Core Animal Facilities to Promote Biosecurity and Biosafety

加强核心动物设施以促进生物安全

• 批准号: 8185697
• 负责人: SUE VANDEWOUDE
• 金额: $ 35.83万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-09 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8185697
• 关键词: 20 year old; Animals; Area; Biomedical Research; Cavia; Colorado; Commit; Communicable Diseases; Containment; Development; Extramural Activities; Faculty; Funding; Grant; Health; Housing; Human; Laboratory Research; Maintenance; Malignant Neoplasms; Principal Investigator; Request for Proposals; Research; Therapeutic Studies; Universities; Vaccines; Wing; animal facility; biosecurity; member; mycobacterial

DESCRIPTION (provided by applicant): This proposal outlines aims to enhance the biosecurity and biocontainment capacity of the primary centralized animal facility at Colorado State University (Painter Center). Specifically, the proposal requests funds to: (1) acquire an oversized (36"W x 62"H x 73"D) bulk sterilizer for the cagewash facility to replace a >20 year old significantly smaller machine (24"W x 36"H x 48"D) that is no longer serviceable; and, (2) renovate the entry/exit area of a specialized wing of the animal facility, currently housing guinea pigs at Animal Biosafety Level 3 containment for Mycobacterial vaccine and therapeutic studies. This proposal will serve 96 identified principal investigators from twelve academic departments with over $130.5M in current extramural grant support, including nearly a dozen faculty member of the world-renowned Mycobacterial Research Laboratories ($54.8M total current funding). CSU recorded a record $303M research portfolio in FY10, an increase of 50% over the past 5 years. Because of the University's focus on infectious disease, cancer, and other biomedical research initiatives, this project will enhance a large portfolio of studies conducted to benefit human health. Consistent with a strong record of support for development and maintenance of state of the art animal facilities, the Vice President for Research has committed funds for renovation of the cagewash to accommodate the autoclave installation requested in this application. The Institutional Biosafety Officer also strongly supports the aims outlined in this proposal that will allow significant biosecurity enhancements to proceed. Construction will be managed with strict consideration of sustainable concepts directed by a LEED Accredited Facilities Professional Project Manager.

描述（由申请人提供）：该提案概述的目的是增强科罗拉多州立大学（画家中心）主要集中动物设施的生物安全和生物防护能力。具体来说，该提案要求资金用于：(1) 为笼式清洗设施购买一台超大（36 英寸宽 x 62 英寸高 x 73 英寸深）的散装灭菌器，以替换一台超过 20 年的小得多的机器（24 英寸宽 x 36 英寸） H x 48"D) 不再可用； (2) 翻新动物设施专用侧翼的入口/出口区域，该区域目前在动物生物安全 3 级收容区内饲养豚鼠，用于分枝杆菌疫苗和治疗研究。该提案将为来自 12 个学术部门的 96 名确定的主要研究人员提供超过 1.305 亿美元的当前校外拨款支持，其中包括世界著名的分枝杆菌研究实验室的近 12 名教职人员（当前总资金为 5480 万美元）。科罗拉多州立大学 2010 财年的研究成果达到创纪录的 3.03 亿美元，比过去 5 年增长了 50%。由于该大学专注于传染病、癌症和其他生物医学研究计划，该项目将加强为造福人类健康而进行的大量研究。与对最先进的动物设施的开发和维护的强有力的支持记录一致，负责研究的副总裁已承诺提供资金用于翻新笼式清洗场，以适应本申请中要求的高压灭菌器安装。机构生物安全官员也强烈支持该提案中概述的目标，这将使生物安全得到重大加强。施工管理将严格考虑可持续概念，并由 LEED 认证设施专业项目经理指导。