Biosecurity Enhancements for the Rocky Mountain Regional Biocontainment Laborator

落基山地区生物防护实验室的生物安全增强

• 批准号: 7629393
• 负责人: SUE VANDEWOUDE
• 金额: $ 47.84万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-16 至 2011-07-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7629393
• 关键词: Animal Housing; Animals; Arboviruses; Area; Colorado; Containment; Disease; Emergency Situation; Equipment; Failure; Funding; Growth; Housing; Infectious Diseases Research; Institution; Laboratories; Laboratory Animals; Modeling; Movement; Mus; Principal Investigator; Process; Research; Research Support; Site; Sterilization for infection control; Universities; animal facility; biosecurity; mycobacterial; pathogen; square foot

DESCRIPTION (provided by applicant): This proposal outlines a plan for capacity building at the Rocky Mountain Regional Biocontainment Laboratory (RMRBL) at Colorado State University. The RMRBL is one component of the CSU Foothills Campus Infectious Disease Research Center (IDRC). By 2010, the IDRC will provide nearly 25,000 sq. ft of total animal space to serve the needs of over 30 current principal investigators and a dozen collaborative institutions. The IDRC supports research on select agents, emerging pathogens, arboviruses, and mycobacterial diseases at Animal Biosafety Levels 2 and 3, and as such, is a unique facility in the Rocky Mountain region, and nationally. We propose here to increase autoclave capacity at the RMRBL cagewash facility to optimize biosafety and biosecurity sterilization of animal caging and equipment. Installation of a large pass-through autoclave is proposed in an area adjacent to the RMRBL animal facility that will also allow emergency redundancy sterilization in the case of failure of the primary decontaminating autoclave. The size and footprint of the proposed equipment is modeled after a highly functional autoclave located in another cagewash facility on campus, allowing equipment redundancy and proof of concept for the proposed machinery. Funding is also requested for movable animal caging to provide high-level containment housing for species other than mice, and transport housing for animal movement between holding areas and manipulation space. Altogether this proposal will fully equip the IDRC, allowing for projected growth of animal use, and the capacity to efficiently and effectively process equipment needed for specialized research performed at the site.

描述（由申请人提供）：该提案概述了科罗拉多州立大学落基山地区生物卫生实验室（RMRBL）的能力建设计划。 RMRBL是CSU Foothills校园传染病研究中心（IDRC）的组成部分。到2010年，IDRC将提供近25,000平方英尺的动物空间，以满足30多名现任首席研究人员和十几个合作机构的需求。 IDRC支持有关动物生物安全水平2和3的精选药物，新兴病原体，arboviruse和分枝菌疾病的研究，因此是落基山地区和全国范围内的独特设施。我们在这里提议提高RMRBL Cagewash设施的高压灭菌能力，以优化动物笼和设备的生物安全和生物安全灭菌。在与RMRBL动物设施附近的区域中提出了大型通行高压灭菌器的安装，该区域还将允许在主要去污染的高压灭菌器失败的情况下进行紧急冗余灭菌。提议的设备的尺寸和占地面积是在校园另一个Cagewash设施中的高功能性高压板上建模的，从而允许设备冗余和概念证明拟议的机械。还要求资金用于可移动的动物笼子，以为小鼠以外的其他物种提供高级遏制外壳，以及用于在存放区域和操纵空间之间动物运动的运输外壳。该提案总的来说将完全配备IDRC，允许预计动物使用的增长，以及在现场进行的专门研究所需的有效处理设备的能力。