Fostering Scientific and Workforce Diversity by Maintaining and Enriching the CHAMACOS Birth Cohort

通过维持和丰富 CHAMACOS 出生队列来促进科学和劳动力多样性

基本信息

批准号：
10588835
负责人：
Kim G. Harley
金额：
$ 38.11万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-30 至 2027-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10588835
关键词：
1 year old 18 year old 20 year old Address Adult Adult Children Age Aging Agriculture Allergens Applications Grants Area Behavioral Biological Biological Markers Biomedical Research Birth Blood California Chemicals Child Child Health Clinical Cohort Studies Collaborations Collection Communities Community Outreach Data Data Collection Deposition Development Dust Ecosystem Education Enrollment Ensure Environmental Epidemiology Environmental Exposure Environmental Health Environmental Impact Epigenetic Process Exposure to FAIR principles Faculty Federally Qualified Health Center Flame Retardants Focus Groups Fostering Funding Future Generations Genetic study Grant Growth Hair Health Health Food High School Student Hispanic-serving Institution Human Human Milk Immigrant Individual Infrastructure Knowledge Latina Population Latino Leadership Link Longitudinal cohort study Low income Measures Mental Health Mentors Middle School Student Migrant Mothers Neighborhoods Obesity Outcome Parents Participant Pesticides Phase Population Pregnancy Protocols documentation Public Health R24 Racial Segregation Research Research Personnel Research Project Grants Resource Sharing Resources Retirement Running Salinas Valley Saliva Sampling Scientific Advances and Accomplishments Stress Structural Racism Students Study of Latinos Tooth structure Underserved Population Unemployment United States National Institutes of Health Urine Visit Woman Work agricultural community biobank cardiometabolism citizen science cohort college community engagement data access data de-identification data management data repository data sharing early life exposure emerging adult environmental chemical environmental enrichment for laboratory animals farm worker graduate student high school higher education improved insight junior high school nasal swab neurodevelopment novel open-access repositories phthalates preservation psychosocial pubertal timing pulmonary function repaired reproductive science teacher social social determinants social health determinants success undergraduate student university student web portal young adult

项目摘要

ABSTRACT CHAMACOS is a longitudinal cohort study of Latino mothers and children from a California farmworker community who have been followed for more than 20 years to assess the impact of environmental exposures and social determinants on children’s health and development. CHAMACOS mothers were enrolled during pregnancy in 1999-2000; they and their children have been seen regularly since then. Over the past two decades, we have amassed a rich trove of behavioral, health, and exposure data from this cohort. Our active biorepository houses 330,000 biological (e.g. blood, urine, breastmilk, hair, saliva, teeth) and environmental samples (e.g. dust, allergens) that we continue to mine for new insights in environmental health. We also hold two decades’ worth of data on children’s neurodevelopment, lung function, physical growth, pubertal timing, cardiometabolic health, and psychosocial functioning and mental health into young adulthood. The cohort currently consists of almost 600 mothers (1st generation) and their 20-22 year old young adult children (2nd generation), some of whom have begun to have children themselves (3rd generation). We propose to begin data collection on the 3rd generation of participants, providing an unprecedented opportunity to assess, under future funding, multigenerational epigenetic effects of environmental exposure and social determinants in a well-characterized Latino cohort. Under the previous R24, we continued our strong community engagement that is vital to retention of the cohort; facilitated new research partnerships; improved our data sharing capabilities, protocols, and transparency through a web-portal; and maintained a strong Biorepository that is poised to address new research questions. In the next phase of this project, under the U24, we will expand on this important work by enriching our cohort with additional data on social determinants of health; laying the groundwork to enroll the 3rd generation of CHAMACOS participants; and promoting scientific and workforce diversity through collaborations with Hispanic-Serving Institutions and students and clinicians from Latino farmworker communities. We will expand resource sharing by making our data publicly available through an open-access data repository and promote sharing of biological and environmental samples through our web portal. Additionally, as the CHAMACOS founders move into retirement, we will transfer the leadership of the cohort to a new generation of investigators to ensure its continued, long-term success. This cohort represents a wealth of resources that should be maintained, enriched, and shared for future research opportunities. It has an engaged Latino participant population that allows scientific insight into an underserved population and provides opportunities to engage young Latino students, clinicians, and junior faculty to build the pipeline of future environmental health researchers.

抽象的 CHAMACOS 是一项针对加州农场工人的拉丁裔母亲和孩子的纵向队列研究 20 多年来一直对社区进行跟踪评估，以评估环境暴露的影响 CHAMACOS 母亲参与了儿童健康和发展的社会决定因素。 1999 年至 2000 年期间，人们经常看到他们和他们的孩子。几十年来，我们从这个活跃人群中积累了丰富的行为、健康和暴露数据。生物储存库容纳了 330,000 个生物（例如血液、尿液、母乳、头发、唾液、牙齿）和环境样本我们还持有样本（例如灰尘、过敏原），以获取有关环境健康的新见解。二十年来关于儿童神经发育、肺功能、身体生长、青春期时间的数据，成年早期的心脏代谢健康、心理社会功能和心理健康。目前由近 600 名母亲（第一代）及其 20-22 岁的年轻成年子女（第二代）组成一代），其中一些人自己也开始生孩子（第三代）。关于第三代参与者的数据收集，提供了前所未有的评估机会未来的资金、环境暴露的多代表观遗传效应和社会决定因素特征鲜明的拉丁裔群体。在之前的 R24 下，我们继续加强社区参与，这对于保留队列；促进新的研究伙伴关系；改进我们的数据共享能力、协议和通过门户网站保持透明度；并维护一个强大的生物存储库，准备解决新问题在该项目的下一阶段，在 U24 的领导下，我们将通过以下方式扩展这项重要工作。丰富我们的队列，提供有关健康的社会决定因素的更多数据，为纳入人群奠定基础；第三代 CHAMACOS 参与者；并通过以下方式促进科学和劳动力多样性：与西班牙裔服务机构以及拉丁裔农场工人的学生和耕种者合作我们将通过开放获取的方式公开我们的数据，从而扩大资源共享。数据存储库并通过我们的门户网站促进生物和环境样本的共享。此外，随着 CHAMACOS 创始人退休，我们将把该团队的领导权移交给新一代调查人员以确保其持续、长期的成功。这个群体代表着丰富的资源，应该为未来维护、丰富和共享它有一个积极参与的拉丁裔参与者群体，可以让人们对一个问题有科学的见解。服务不足的人群，并提供机会吸引年轻的拉丁裔学生、顾客和青少年教师建立未来环境健康研究人员的管道。