Endocrine disrupting and immune effects of Triclosan in children

三氯生对儿童的内分泌干扰和免疫影响

基本信息

批准号：
9010955
负责人：
Kim G. Harley
金额：
$ 7.8万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-02-06 至 2017-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9010955
关键词：
12 year old 5 year old 7 year old 9 year old Address Adult Age Allergic American Animals Anti-Bacterial Agents Antibiotic Resistance Asthma Biological Biological Markers Birth Blood CD4 Positive T Lymphocytes California Chemicals Child Childhood Childhood Asthma Clinical Cohort Studies Data Data Analyses Data Set Dermal Development Diagnosis Dose Endocrine Endocrine Disruptors Endocrine disruption Endocrine system Environmental Exposure Exposure to Female Follicle Stimulating Hormone Foundations Funding Future Gonadal Steroid Hormones Growth Half-Life Hand Health Helper-Inducer T-Lymphocyte Homeostasis Hormones Human Hypersensitivity IgE Immune Immune system In Vitro Infant Ingestion Life Link Liquid substance Long-Term Effects Longitudinal Studies Low income Luteinizing Hormone Measurement Measures Medical Records Mexican Americans Mothers Mouthwash National Health and Nutrition Examination Survey Newborn Infant Outcome Perinatal Exposure Personal Communication Phenols Physicians Policies Pregnancy Pregnant Women Prospective Studies Puberty Reporting Research Risk Rodent Safety Salinum Sampling School-Age Population Soaps Spirometry Spottings Staging Symptoms Testosterone Thyroid Hormones Thyrotropin Thyroxine Time TimeLine Toothpaste Triclosan United States Environmental Protection Agency United States Food and Drug Administration Urine Work abstracting antimicrobial bisphenol A boys cohort critical period cytokine early childhood early onset estrogenic girls high reward high risk human data in utero male meetings neonate personal care products prenatal prospective pubertal timing response urinary

项目摘要

DESCRIPTION (provided by applicant): Exposure to triclosan, an antibacterial agent used in soaps, toothpaste, and other personal care products, is widespread, with 75% of Americans having detectable levels in their bodies. In vitro and animal studies show that triclosan is an endocrine disruptor. In rodent studies, triclosan exposure during critical windows of development lowers levels of the thyroid hormone thyroxine (T4), increases allergic sensitivity and asthma-like response, decreases testosterone in males, and alters pubertal timing in females. To date, only a small number of studies have examined health effects of triclosan in humans, focusing on school-age children and adults. These studies provide some confirmation of effects on endocrine and immune systems, but they do not address exposure in utero - a critical period for endocrine disruption and immune development - and thus likely underestimate triclosan's potential health impact. Both the U.S. Food and Drug Administration (FDA) and Environmental Protection Agency (EPA) are embarking on comprehensive regulatory reviews of triclosan, but are challenged by a dearth of human data. High-quality, independent research assessing associations of prenatal and early childhood triclosan exposures with subsequent health effects are urgently needed. The Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) is a longitudinal birth cohort study that has gathered comprehensive data on environmental exposures, health, and development in more than 300 children who have participated from before birth through age 12. We propose to characterize urinary triclosan concentrations from CHAMACOS mothers during pregnancy and their children at 5 and 9 years of age and to examine the potential impact of this exposure on: 1) thyroid hormone homeostasis in pregnant women and newborns, 2) allergy and asthma symptoms in children at ages 5 and 7, and 3) timing of puberty and sex hormone levels in children between ages 9 and 12. We have already collected most of the data needed to achieve these aims, and crude, preliminary analyses suggest associations of triclosan with decreased T4 and increased risk of asthma symptoms in this cohort. However, the work needed to finalize urinary triclosan measurements, obtain additional outcome data, and conduct sophisticated data analyses that control for longitudinal effects and confounding cannot be completed without dedicated funding. This study is exploratory, because it is the first longitudinal study of developmental triclosan exposure; developmental, in that it lays groundwork for future in-depth research; and high risk, because we hope to have results in time to inform pending policy decisions. By relying on a rich existing data, this project can be completed in just two years, promising high regulatory and scientific impact.

描述（由申请人提供）：接触三氯生（一种用于肥皂、牙膏和其他个人护理产品的抗菌剂）的情况很普遍，75% 的美国人体内可检测到三氯生。体外和动物研究表明，三氯生是一种内分泌干扰物。在啮齿类动物研究中，在关键发育窗口期接触三氯生会降低甲状腺激素甲状腺素 (T4) 的水平，增加过敏敏感性和哮喘样反应，降低雄性睾酮水平，并改变雌性青春期时间。迄今为止，只有少数研究探讨了三氯生对人类健康的影响，主要针对学龄儿童和成人。这些研究提供了对内分泌和免疫系统影响的一些确认，但它们没有解决子宫内的暴露问题——这是内分泌干扰和免疫发育的关键时期——因此可能低估了三氯生的潜在健康影响。美国食品和药物管理局 (FDA) 和环境保护局 (EPA) 正在着手对三氯生进行全面的监管审查，但面临着缺乏人体数据的挑战。迫切需要高质量、独立的研究来评估产前和幼儿期三氯生暴露与随后的健康影响之间的关系。萨利纳斯母婴健康评估中心 (CHAMACOS) 是一项纵向出生队列研究，收集了 300 多名从出生前到 12 岁参与的儿童的环境暴露、健康和发育方面的全面数据。建议表征 CHAMACOS 母亲在怀孕期间及其 5 岁和 9 岁时孩子的尿液中三氯生浓度，并检查这种暴露对以下方面的潜在影响：1) 孕妇的甲状腺激素稳态和新生儿，2) 5 至 7 岁儿童的过敏和哮喘症状，以及 3) 9 至 12 岁儿童的青春期时间和性激素水平。我们已经收集了实现这些目标所需的大部分数据，并且粗略地初步分析表明，三氯生与该队列中 T4 降低和哮喘症状风险增加有关。然而，如果没有专门的资金，就无法完成尿三氯生测量、获得额外结果数据以及进行控制纵向效应和混杂因素的复杂数据分析所需的工作。这项研究是探索性的，因为它是第一个针对发育期三氯生暴露的纵向研究；发展性的，因为它为未来的深入研究奠定了基础；风险高，因为我们希望及时得到结果，为悬而未决的政策决定提供信息。依靠丰富的现有数据，该项目可以在短短两年内完成，有望产生很高的监管和科学影响。