Factors associated with persistent anal human papillomavirus infection among men

男性持续性肛门人乳头瘤病毒感染的相关因素

• 批准号: 8601246
• 负责人: ALAN GASPAR NYITRAY
• 金额: $ 30.1万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-22 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8601246
• 关键词: Factors; associated; persistent; anal; human; Factors; associated; persistent; anal; human

DESCRIPTION (provided by applicant): Anal cancer is primarily caused by oncogenic human papillomavirus (HPV) types. Persistence of oncogenic HPV infection is the most important early biological event that marks increased risk for development of precancerous anal intraepithelial neoplasia. Annual anal cancer incidence among HIV-negative men having sex with men (MSM) in the US is several fold higher than cervical cancer incidence among women. It is unknown why only some MSM have persistent anal HPV infection and thus increased risk for anal cancer. Such data are especially critical now for two reasons: 1) current HPV vaccines have not been recommended for boys and men, and 2) current vaccines are not licensed for use among men older than 26 years of age. Thus, a fuller understanding of persistent anal HPV infection, is important for the development of anal cancer interventions among MSM. The Moffitt Cancer Center is uniquely positioned for this research as a result of its collection and archiving of anal canal specimens in the Human Papillomavirus in Men Study (HIM Study: NIH R01 CA098803 01), a longitudinal study investigating penile and scrotal HPV infections in men, ages 18-70 years. The HIM Study recruited men in Brazil, Mexico, and the United States beginning in 2005 and also added a post-award protocol to collect anal canal exfoliated cell specimens (anal canal specimen collection and testing was not funded by R01 CA098803 01). The proposed 2-year natural history study will analyze archived biological specimens and behavioral data from 950 men. The men included comprise two groups: all MSM with archived anal specimens (n=357) and a random sample of MSW with archived anal specimens (n=593). We hypothesize that anal HPV infection persistence in MSM is more common than in MSW and is associated with cigarette smoking among MSM. To test the hypothesis, we designed two Specific Aims: 1. Estimate persistence of type-specific anal HPV among MSM and MSW over a 24 month period; and 2. Determine factors independently associated with persistence of anal HPV including age, sexual behavior, cigarette smoking, concurrent sexually transmitted infections, and HPV antibodies. Given the infrastructure and sample size available with the HIM Study, the proposed research is powered to produce findings on HPV persistence that address fundamental questions related to anal cancer. Our proposed research will produce the first robust estimates of anal HPV persistence in MSM and MSW recruited cross-nationally from the general community.

描述（由申请人提供）：肛门癌主要由致癌性人乳头瘤病毒（HPV）类型引起。致癌性HPV感染的持续性是最重要的早期生物学事件，标志着癌前肛门上皮内肿瘤发展的风险增加。 在美国，与男性发生性关系（MSM）的HIV阴性男性中的年度肛门癌发病率高几倍，女性比宫颈癌发病率高。尚不清楚为什么只有一些MSM持续存在肛门HPV感染，因此增加了肛门癌的风险。目前尤其重要的是，此类数据的原因有两个：1）目前不建议男孩和男性使用HPV疫苗，而2）当前的疫苗未获得许可用于26岁以上的男性。因此，对持续性肛门HPV感染的更全面了解对于MSM之间的肛门癌干预非常重要。 莫菲特癌症中心由于其收集和存档而在这项研究中独特地定位 人类乳头瘤病毒研究中的运河标本研究（他研究：NIH R01 CA098803 01），这是一项纵向研究，研究了18-70岁的男性的阴茎和阴囊HPV感染。这项研究从2005年开始招募在巴西，墨西哥和美国的男性，还添加了一项雄辩后的方案，用于收集肛管剥落的细胞样品（肛管的收集和测试未由R01 CA098803 01资助）。 拟议的两年自然历史研究将分析来自950名男性的存档生物标本和行为数据。这些人包括两组：所有具有存档的肛门样本的MSM（n = 357）和带有存档的肛门样品的MSW随机样本（n = 593）。 我们假设MSM中的肛门HPV感染持久性比MSW中更常见，并且与MSM中的吸烟有关。为了检验假设，我们设计了两个具体的目的：1。在24个月内，MSM和MSW中类型特异性肛门HPV的估计持续性；和2。确定与肛门HPV持续性独立相关的因素，包括年龄，性行为，吸烟，并发性传播感染和HPV抗体。 鉴于HIM研究可用的基础架构和样本量，拟议的研究旨在提出有关HPV持久性的发现，该发现解决了与肛门癌有关的基本问题。 我们提出的研究将产生对MSM肛门HPV持久性的第一个强大估计，而MSW则从一般社区进行了交叉招募。