Factors associated with persistent anal human papillomavirus infection among men

男性持续性肛门人乳头瘤病毒感染的相关因素

• 批准号: 8601246
• 负责人: ALAN GASPAR NYITRAY
• 金额: $ 30.1万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-22 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8601246
• 关键词: Factors; associated; persistent; anal; human

DESCRIPTION (provided by applicant): Anal cancer is primarily caused by oncogenic human papillomavirus (HPV) types. Persistence of oncogenic HPV infection is the most important early biological event that marks increased risk for development of precancerous anal intraepithelial neoplasia. Annual anal cancer incidence among HIV-negative men having sex with men (MSM) in the US is several fold higher than cervical cancer incidence among women. It is unknown why only some MSM have persistent anal HPV infection and thus increased risk for anal cancer. Such data are especially critical now for two reasons: 1) current HPV vaccines have not been recommended for boys and men, and 2) current vaccines are not licensed for use among men older than 26 years of age. Thus, a fuller understanding of persistent anal HPV infection, is important for the development of anal cancer interventions among MSM. The Moffitt Cancer Center is uniquely positioned for this research as a result of its collection and archiving of anal canal specimens in the Human Papillomavirus in Men Study (HIM Study: NIH R01 CA098803 01), a longitudinal study investigating penile and scrotal HPV infections in men, ages 18-70 years. The HIM Study recruited men in Brazil, Mexico, and the United States beginning in 2005 and also added a post-award protocol to collect anal canal exfoliated cell specimens (anal canal specimen collection and testing was not funded by R01 CA098803 01). The proposed 2-year natural history study will analyze archived biological specimens and behavioral data from 950 men. The men included comprise two groups: all MSM with archived anal specimens (n=357) and a random sample of MSW with archived anal specimens (n=593). We hypothesize that anal HPV infection persistence in MSM is more common than in MSW and is associated with cigarette smoking among MSM. To test the hypothesis, we designed two Specific Aims: 1. Estimate persistence of type-specific anal HPV among MSM and MSW over a 24 month period; and 2. Determine factors independently associated with persistence of anal HPV including age, sexual behavior, cigarette smoking, concurrent sexually transmitted infections, and HPV antibodies. Given the infrastructure and sample size available with the HIM Study, the proposed research is powered to produce findings on HPV persistence that address fundamental questions related to anal cancer. Our proposed research will produce the first robust estimates of anal HPV persistence in MSM and MSW recruited cross-nationally from the general community.

描述（由申请人提供）：肛门癌主要由致癌人乳头瘤病毒（HPV）类型引起。致癌性 HPV 感染的持续存在是最重要的早期生物学事件，标志着发生癌前肛门上皮内瘤变的风险增加。 在美国，艾滋病毒阴性男男性行为者 (MSM) 的每年肛门癌发病率比女性宫颈癌发病率高几倍。目前尚不清楚为什么只有一些 MSM 具有持续的肛门 HPV 感染，从而增加患肛门癌的风险。这些数据现在尤其重要，原因有两个：1) 目前的 HPV 疫苗尚未推荐给男孩和男性，2) 目前的疫苗尚未获准在 26 岁以上的男性中使用。因此，更全面地了解持续性肛门 HPV 感染对于 MSM 中肛门癌干预措施的发展非常重要。 莫菲特癌症中心在这项研究中处于独特的地位，因为它收集和存档了肛门 男性人乳头瘤病毒研究（HIM 研究：NIH R01 CA098803 01）中的运河标本，这是一项调查 18-70 岁男性阴茎和阴囊 HPV 感染的纵向研究。 HIM 研究从 2005 年开始在巴西、墨西哥和美国招募男性，并增加了一项获奖后协议来收集肛管脱落细胞标本（肛管标本收集和测试并未由 R01 CA098803 01 资助）。 拟议的为期 2 年的自然历史研究将分析 950 名男性的存档生物标本和行为数据。纳入的男性由两组组成：所有具有存档肛门标本的 MSM（n=357）和具有存档肛门标本的 MSW 随机样本（n=593）。 我们假设 MSM 中肛门 HPV 持续感染比 MSW 中更常见，并且与 MSM 中吸烟有关。为了检验这一假设，我们设计了两个具体目标： 1. 估计 MSM 和 MSW 中特定类型肛门 HPV 在 24 个月内的持续存在情况； 2. 确定与肛门 HPV 持续存在独立相关的因素，包括年龄、性行为、吸烟、并发性传播感染和 HPV 抗体。 考虑到 HIM 研究可用的基础设施和样本量，拟议的研究有望得出有关 HPV 持久性的发现，从而解决与肛门癌相关的基本问题。 我们提出的研究将对从普通社区跨国招募的 MSM 和 MSW 中肛门 HPV 持续性进行首次可靠的估计。