Prevalence and Risk Factors for Anal Human Papillomavirus in Heterosexual Men: Th

异性恋男性中肛门人乳头瘤病毒的患病率和危险因素：Th

基本信息

批准号：
7599220
负责人：
ALAN GASPAR NYITRAY
金额：
$ 11.68万
依托单位：
H. LEE MOFFITT CANCER CTR & RES INST
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-04-01 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7599220
关键词：
Age Anal canal Anogenital Human Papilloma Virus Infection Anogenital cancer Anus Archives Arizona Behavioral Biological Brazil Cancer Burden Cancer Center Characteristics Coitus Collaborations Communities Confidence Intervals Country Cross-Sectional Studies Data Data Analyses Epidemiology Female Florida Frequencies Genotype Goals Heterosexuals Human Papillomavirus Human papillomavirus 6 Incidence Infection International Laboratories Learning Malignant neoplasm of anus Malignant neoplasm of cervix uteri Mexico Multivariate Analysis Oncogenic Polymerase Chain Reaction Population Prevalence Prevention approach Recording of previous events Recruitment Activity Reporting Research Research Design Research Institute Research Personnel Risk Factors Sampling Sex Behavior Sexual Partners Sexually Transmitted Diseases Specimen Testing Time United States Vaccination Woman base experience male man men prospective sex

项目摘要

DESCRIPTION (provided by applicant): Human papillomavirus (HPV) is a sexually transmitted infection and primary cause of anal cancer. While male anal cancer incidence in the US has increased almost threefold in three decades, anal HPV prevalence and risk factors in men, especially heterosexual men, remain largely unknown. We have recently estimated an anal canal HPV prevalence of 16.6% in 222 men who denied any lifetime sex with another man. In our analysis of these data, we also found significant univariate associations between anal HPV and decreased age, increased lifetime number of female sexual partners, and frequency of sexual intercourse in the previous month. In multivariate analysis, number of lifetime sexual partners and frequency of sex was independently associated with anal HPV. Our long term goal is to increase our understanding of anal HPV in heterosexual men so that prevention approaches such as vaccination can be developed and implemented to reduce anal cancer burden. The focus of this application is to determine the prevalence and risk factors for anal HPV in heterosexual men. Our hypothesis is that anal HPV in heterosexual men is a common infection inversely associated with age. This hypothesis can be efficiently tested given the availability of anal canal specimens from a large multinational study conducted by our collaborators at the H. Lee Moffitt Cancer Center. Dr. Anna Giuliano and colleagues have collected and archived anal canal samples from 1200 men recruited in Tampa, Florida; Morelos state, Mexico; and Sao Paulo, Brazil. We propose to test these anal canal samples for HPV. The specific aims of this cross-sectional study are designed to exploit the availability of the anal canal specimens from the larger study of 1200 men: Specific Aim 1. Using archived anal canal samples, determine the type-specific anal HPV prevalence in 1200 men; and Specific Aim 2. Identify factors independently associated with anal HPV in the 1200 men. HPV is a common sexually transmitted infection responsible for a variety of anogenital cancers including anal cancers in men. However, a high anal HPV prevalence in heterosexual men, if confirmed, will challenge assumptions about the epidemiology of HPV in men. The dramatically increased incidence of anal cancers in men in the last three decades underscores the need to learn more about prevalence of anal HPV in men (Specific Aim 1) and the risk factors most commonly associated with anal HPV in these men (Specific Aim 2). The focus of this application is to determine the prevalence and risk factors for anal HPV in 1200 heterosexual men. Our hypothesis is that anal HPV in heterosexual men is a common infection inversely associated with age.

描述（由申请人提供）：人乳头瘤病毒 (HPV) 是一种性传播感染，也是肛门癌的主要原因。虽然美国男性肛门癌的发病率在三十年来几乎增加了三倍，但男性（尤其是异性恋男性）肛门 HPV 的患病率和危险因素仍然很大程度上未知。我们最近估计，在 222 名否认一生与另一名男子发生过性行为的男性中，肛管 HPV 患病率为 16.6%。在对这些数据的分析中，我们还发现肛门 HPV 与年龄下降、一生中女性性伴侣数量增加以及上个月性交频率之间存在显着的单变量关联。在多变量分析中，终生性伴侣的数量和性行为频率与肛门 HPV 独立相关。我们的长期目标是增加我们对异性恋男性肛门 HPV 的了解，以便制定和实施疫苗接种等预防方法，以减少肛门癌负担。该应用的重点是确定异性恋男性中肛门 HPV 的患病率和危险因素。我们的假设是，异性恋男性的肛门 HPV 是一种常见感染，与年龄成反比。鉴于我们的合作者在 H. Lee Moffitt 癌症中心进行的一项大型跨国研究中提供了肛管标本，这一假设可以得到有效检验。 Anna Giuliano 博士及其同事收集并存档了在佛罗里达州坦帕招募的 1200 名男性的肛管样本；墨西哥莫雷洛斯州；和巴西圣保罗。我们建议对这些肛管样本进行 HPV 检测。这项横断面研究的具体目标旨在利用来自 1200 名男性的更大规模研究中的肛管标本的可用性：具体目标 1. 使用存档的肛管样本，确定 1200 名男性中特定类型的肛门 HPV 患病率；具体目标 2. 确定 1200 名男性中与肛门 HPV 独立相关的因素。 HPV 是一种常见的性传播感染，可导致多种肛门生殖器癌症，包括男性肛门癌。然而，异性恋男性肛门 HPV 的高患病率如果得到证实，将挑战有关男性 HPV 流行病学的假设。过去三十年中男性肛门癌发病率急剧增加，这凸显了需要更多地了解男性肛门 HPV 的患病率（具体目标 1）以及这些男性中与肛门 HPV 最常见相关的危险因素（具体目标 2）。此应用的重点是确定 1200 名异性恋男性中肛门 HPV 的患病率和危险因素。我们的假设是，异性恋男性的肛门 HPV 是一种常见感染，与年龄成反比。