The Role of Sleep in the Relationships Among Adverse Childhood Experiences, Mental Health Symptoms, and Persistent/Recurrent Pain during Adolescence

睡眠在不良童年经历、心理健康症状和青春期持续/复发性疼痛之间关系中的作用

• 批准号: 10676403
• 负责人: Thea Senger-Carpenter
• 金额: $ 4.47万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-28 至 2025-06-27
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10676403
• 关键词: Abdominal Pain; Adolescence; Adolescent; Affect; Age; American; Anxiety; Brain; Buffers; Camellia sinensis; Community Health; Data; Data Analyses; Development; Early Intervention; Equation; Ethnic Origin; Exposure to; Fellowship; Female; Funding; Future; Goals; Headache; Health; Inequity; Intervention; Longitudinal Studies; Maintenance; Manuscripts; Mediation; Mental Depression; Mental Health; Mentorship; Methodology; Michigan; Modeling; National Institute of Nursing Research; Nurses; Outcome; Pain; Pathway interactions; Persistent pain; Personal Satisfaction; Productivity; Psyche structure; Publications; Race; Recurrent pain; Research; Research Project Grants; Risk; Risk Factors; Role; School Nursing; Scientist; Sleep; Sleep Deprivation; Socioeconomic Status; Strategic Planning; Symptoms; Teenagers; Testing; Training; Training Programs; United States; United States National Institutes of Health; Universities; Youth; advanced analytics; adverse childhood events; anxiety symptoms; associated symptom; biopsychosocial; career; career networking; cognitive development; cost; depressive symptoms; early adolescence; ethnic minority; experience; hands on research; health care service utilization; health equity; health inequalities; insight; low socioeconomic status; pain symptom; physical conditioning; physical symptom; poor sleep; population health; prevent; prospective; racial minority; reduce symptoms; sex; skills; sleep health; socioeconomics; theories; vulnerable adolescent; young adult

PROJECT SUMMARY The goal of this fellowship is to prepare the applicant, Thea Senger-Carpenter, as a nurse-scientist studying relationships among adolescent sleep, adverse childhood experiences (ACEs), and associated symptoms and outcomes. To that end, the proposed fellowship consists of two complementary components: (1) a training plan comprising formal training, mentorship, hands-on research, manuscript publication, and professional development activities and (2) a research project that will further our understanding of how sleep affects the relationships among ACEs, mental health symptoms and persistent or recurrent pain (PRP) during adolescence. The applicant will be supported by a strong mentorship team with sponsors at the University of Michigan School of Nursing and Yale School of Nursing. Together, the mentorship team provides expertise in adolescent sleep, pain and associated symptoms, and ACE exposure. The training program will help the applicant develop: a) expertise in adolescent sleep, PRP, and the sequelae of ACE exposure, b) methodological skills in longitudinal, multivariate data analysis and c) engage in the dissemination of research findings and professional networking activities. Sleep deficiency affects up to two-thirds of American adolescents and is a risk factor for PRP, anxiety, and depression. ACE exposure is similarly prevalent, affecting around half of U.S. teens, and has been associated with both PRP and mental health symptoms. Importantly, sleep deficiency may moderate the effect of ACE exposure on other health outcomes. However, little is known about how sleep deficiency impacts the relationships among ACE exposure, mental health symptoms, and PRP across adolescence nor how these relationships differ by race, ethnicity, socioeconomic status (SES), and sex. Thus, the aims of the proposed project are 1) to determine whether and how sleep deficiency moderates the indirect effect of ACEs on PRP through mental health symptoms and 2) to describe how these relationships differ by race, ethnicity, SES, and sex. All aims will be investigated using the Adolescent Brain Cognitive Development Study, an ongoing NIH- funded longitudinal study of youth development in the United States. This proposed project integrates the research lenses of health equity and population and community health outlined in the National Institute of Nursing Research's strategic plan. By identifying sleep as a modifiable target for intervention, our findings have the potential to reduce the symptom burden of adolescents exposed to ACEs and mitigate racial, ethnic, socioeconomic, and sex-based inequities in health outcomes.

项目摘要 该奖学金的目的是为申请人thea senger-carpenter做好准备，作为护士科学家学习 青少年睡眠之间的关系，不良的童年经历（ACE）和相关症状以及 结果。为此，拟议的奖学金包括两个互补组成部分：（1）培训计划 包括正式培训，指导，动手研究，手稿出版和专业 开发活动和（2）一个研究项目，将进一步了解睡眠如何影响 ACE，心理健康症状以及持续或经常性疼痛（PRP）之间的关系 青春期。申请人将得到一个强大的指导团队的支持 密歇根州护理学院和耶鲁大学护理学院。指导团队一起提供了专业知识 青少年睡眠，疼痛和相关症状以及ACE暴露。培训计划将帮助 申请人发展：a）青少年睡眠，PRP和ACE暴露后遗症的专业知识，b） 纵向，多元数据分析和c）进行研究的方法学技能 调查结果和专业网络活动。 睡眠不足会影响多达三分之二的美国青少年，是PRP，焦虑和 沮丧。王牌的暴露同样普遍，影响了美国青少年的一半，并且已经相关 有PRP和心理健康症状。重要的是，睡眠不足可能减轻ACE的影响 其他健康结果的曝光。但是，对于睡眠不足如何影响 在青春期中，ACE暴露，心理健康症状和PRP之间的关系或这些如何 关系因种族，种族，社会经济地位（SES）和性别而有所不同。因此，提议的目的 项目是1）确定睡眠不足是否以及如何适应ACE对PRP的间接影响 通过心理健康症状和2）描述这些关系如何因种族，种族，SES和 性别。所有目标将使用青少年的大脑认知发展研究进行研究，这是一项正在进行的NIH- 资助了美国青年发展的纵向研究。 该提议的项目整合了健康公平和人口和社区健康的研究镜头 在美国国家护理研究所的战略计划中概述。通过将睡眠识别为可修改的 干预的目标，我们的发现有可能减轻暴露于青少年的症状负担 王牌和减轻种族，种族，社会经济和基于性别的不平等现象。