New England Gastropareis Consortium: Neurobiology of Gastroparesis

新英格兰胃轻瘫联盟：胃轻瘫的神经生物学

• 批准号: 10842564
• 负责人: Braden Kuo
• 金额: $ 6.18万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-25 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10842564
• 关键词: Abdominal Pain; Adolescence; Adolescent; Adult; Ancillary Study; Assessment tool; COVID-19 pandemic effects; Categories; Characteristics; Child; Childhood; Chronic; Clinical; Clinical Research; Clinical Trials; Consent; Data; Development; Diabetes Mellitus; Disease; Distress; Dyspepsia; Epigastrium; Etiology; Functional Gastrointestinal Disorders; Functional disorder; Future; Gastric Emptying; Gastroparesis; General Population; Goals; Hospitalization; Incidence; Knowledge; Measures; Mechanics; Methodology; Methods; Molecular; Morbidity - disease rate; National Institute of Diabetes and Digestive and Kidney Diseases; Natural History; Nausea and Vomiting; Neurobiology; New England; Nutritional; Obstruction; Operative Surgical Procedures; Outcome Assessment; Pain; Patients; Periodicity; Physiological; Population; Prevalence; Process; Protocols documentation; Quality of life; Questionnaires; Registries; Research; Rome; Sample Size; Severities; Severity of illness; Site; Source; Stomach; Symptoms; Syndrome; Therapeutic Clinical Trial; Therapeutic Studies; Toddler; Treatment outcome; Vomiting; Work; adverse outcome; age group; age related; cell motility; chronic abdominal pain; clinical care; cohort; common symptom; comorbidity; cost; dietary; early satiety; effective therapy; gastrointestinal; improved; innovation; insight; interdisciplinary approach; mortality; neuropathology; pediatric patients; prospective; psychologic; psychosocial; recruit

ABSTRACT Gastroparesis (Gp) in children and adults is characterized by delayed gastric emptying in the absence of mechanical obstruction. GP is associated with significant morbidity and mortality, yet little is known regarding its incidence, prevalence, and natural history in children. This knowledge gap in pediatric Gp is exacerbated by the overlap in symptoms and pathophysiology with functional dyspepsia (FD), a common disorder in adults and children. The limited data suggests significant differences between clinical symptoms and pathophysiology of Gp and FD in children vs adults. Thus, data regarding Gp and FD in adults is unlikely to provide insight and fill the knowledge gaps regarding Gp and FD in children. These issues (among others) underscore the need for childhood Gp- and FD-specific research strategies. Thus, the goals of this supplemental application are to build on and extend our Pediatric Gp Registry 2 (PGpR2) work as part of the NIDDK Gastroparesis Consortium (GpCRC) ultimately, to determine the factors contributing to disease severity measured by quality of life and symptoms. The Specific Aims of the current project are to: Aim 1: Create a national prospective registry of children and adolescents with gastroparesis Gp) and Gp-like syndrome (GLS; the latter group, using pediatric Rome IV criteria will be characterized as having FD (functional dyspepsia, including the two subtypes [FD-EPS, FD-PDS]), chronic nausea vomiting syndrome, cyclic vomiting syndrome, and/or chronic abdominal pain syndrome to include demographic, clinical, psychological, nutritional characteristics, physiological measures, and serial assessments of symptoms over 3 years during their clinical care. Aim 2: Follow this well-characterized cohort to further define the natural history, clinical course, and selected physiologic measures of children and adolescents with symptoms of Gp. Aim 3: Provide a reliable source for recruitment of well-characterized children and adolescents with Gp and FD for other studies including therapeutic clinical trials, pathophysiological, molecular, histopathologic, or other ancillary studies. These subsequent clinical trials or ancillary studies will be conducted under separate study protocols with separate consent processes. Supplement Aim: Expand the number of pediatric sites within the PGpR2 to facilitate recruitment and consequently, the goals of the PGpR2. This innovative multidisciplinary approach will prospectively begin to fill the vast knowledge void regarding Gp and FD in children. The current supplement proposal is responsive to RFA-DK-20-504 and PA-20-272 by achieving among other goals, to build on our previous gains and expand the number of pediatric sites to enhance recruitment.

抽象的 儿童和成人中的胃轻瘫（GP）的特征是胃排空延迟在没有的情况下 机械阻塞。 GP与显着的发病率和死亡率有关，但关于其的发病率和死亡率很少 儿童的发病率，患病率和自然历史。小儿GP中的这种知识差距会因 症状和病理生理学与功能性消化不良（FD）的重叠，成人的常见疾病和 孩子们。有限的数据表明临床症状与病理生理学之间的显着差异 儿童与成人的GP和FD。因此，成人中有关GP和FD的数据不太可能提供洞察力并填补 关于儿童GP和FD的知识差距。这些问题（除其他问题）强调了需要 儿童时期的GP和FD特定研究策略。因此，此补充应用的目标是建立 在NIDDK胃癌联盟的一部分上，开上并扩展了我们的小儿GP注册表2（PGPR2） （GPCRC）最终，确定导致疾病严重程度的因素，从生活质量和 症状。当前项目的具体目的是： 目标1：用胃轻瘫的儿童和青少年创建国家准登记处）和类似GP 综合征（GLS；后一组，使用小儿罗马IV标准将被表征为具有FD（功能性） 消化不良，包括两种亚型[FD-EPS，FD-PDS]），慢性恶心呕吐综合征，环状呕吐 综合征和/或慢性腹痛综合征，包括人口统计学，临床，心理，营养 在临床期间，症状的特征，生理测量和串行评估 关心。 目标2：遵循此特征良好的队列以进一步定义自然史，临床过程并选择 患有GP症状的儿童和青少年的生理测量。 AIM 3：提供可靠的来源，以招募有GP和GP的良好儿童和青少年 FD用于其他研究，包括治疗性临床试验，病理生理，分子，组织病理学或其他 辅助研究。这些随后的临床试验或辅助研究将在单独的研究下进行 具有单独同意过程的协议。 补充目的：扩大PGPR2中儿科部位的数量，以促进招聘和 因此，PGPR2的目标。 这种创新的多学科方法将开始填补有关的广阔知识空白 GP和FD儿童。当前的补充提案对RFA-DK-20-504和PA-20-272响应 实现其他目标，建立我们以前的收益并扩大儿科地点的数量以增强 招聘。

项目成果

Colonic motor response to wakening is blunted in slow transit constipation as detected by wireless motility capsule.

无线运动胶囊检测到，在慢传输型便秘中，结肠运动对唤醒的反应减弱。

• DOI: 10.1038/s41424-018-0012-9
• 发表时间: 2018
• 期刊: Clinical and translational gastroenterology
• 影响因子: 3.6
• 作者: Surjanhata,Brian;Barshop,Kenneth;Staller,Kyle;Semler,Jack;Guay,Laurence;Kuo,Braden
• 通讯作者: Kuo,Braden