Cancer GENETICS AND EPIGENETICS

癌症遗传学和表观遗传学

基本信息

批准号：
8512116
负责人：
Paula M. Vertino
金额：
$ 3.02万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-01 至 2017-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8512116
关键词：
Affect Area Automobile Driving Basic Science Bioinformatics Biometry Brain Breast Cancer Center Support Grant Cells Chromatin Chromosomal Instability Classification Clinical Collaborations DNA DNA Damage DNA Repair DNA Sequence Defect Detection Development Diagnosis Direct Costs Disease Outcome Doctor of Philosophy Epigenetic Process Failure Functional RNA Funding Gene Expression Regulation Genes Genetic Genome Genomic Instability Genomics Genomics Shared Resource Goals Grant Human Individual Institutes Instruction Investigation Journals Lung Malignant Neoplasms Methylation MicroRNAs Molecular Molecular Classification of Tumors Mutation Normal Cell Nucleotides Outcome Oxidative Stress Pathway interactions Patients Pattern Peer Review Phenotype Positioning Attribute Prevention Program Development Prostate Public Health Schools Publications Publishing Research Research Activity Research Infrastructure Research Personnel Research Project Grants Schools Screening procedure Source System Therapeutic Therapeutic Intervention Translating Translations Universities Variant anticancer research cancer care cancer cell cancer genetics cancer genome cancer genomics cancer initiation cancer therapy college environmental radiation gene function genetic analysis genome-wide histone modification improved medical schools member mortality novel novel strategies outcome forecast prognostic programs radiation carcinogen radiation carcinogenesis repaired response small molecule translational study tumor tumor progression tumorigenesis

项目摘要

PROJECT SUMMARY: The goal of the Cancer Genetics and Epigenetics (CGE) Program is to better understand the fundamental mechanisms underlying genetic and epigenetic instability and its contribution to the initiation and progression of human tumors. In pursuit of this goal, the program organizes its research efforts into three areas of focus: 1) DNA damage and repair and genome instability; 2) epigenetics and gene regulation; and 3) cancer genetics /genomics. The CGE Program consists of 29 core members from 13 academic departments and three schools across Emory University, including the School of Medicine, the School of Public Health and Emory College. CGE Program members currently have $15,110,592 in research grant funding (annual direct costs), of which $12,849,105 is peer-reviewed and $4,277,290 (34%) is NCI-funded. Program members have published 227 cancer-related publications in the cun-ent project period. Among these, 12% and 25% represent intra- and inter-programmafic and interactions, respectively. In the current project period, discovery efforts have led to the identification of key genes whose mutation or altered expression contribute to cancer initiation and progression. Basic discoveries in the area of cancer epigenetics have prompted early small molecule screening efforts to identify novel targeted agents. Program development and key recruitments have strengthened and enhanced intra-programmatic activities in the areas of human radiation carcinogenesis, DNA damage/repair, and cancer genomics. This has been leveraged into several new multi-investigator grants and has provided key translational avenues for the program through increased inter-programmatic activities and cross-cutting genomics initiatives. Successful genomic studies resulted in the molecular classification of tumors and the identification of genes, gene signatures, and clinical factors with prognostic value in prostate, breast, brain, and lung malignancies. The Cancer Genetics and Epigenetics Program facilitates scientific collaborations and cancer research discoveries and has positioned itself for continued development in the forthcoming project period.

项目摘要：癌症遗传学和表观遗传学（CGE）计划的目标是更好地了解遗传和表观遗传不稳定性的基本机制及其对人肿瘤起始和进展的贡献。为了实现这一目标，该计划将其研究工作组织为三个重点领域：1）DNA损害和修复以及基因组不稳定性； 2）表观遗传学和基因调节； 3）癌症遗传学 /基因组学。 CGE计划由来自13个学术系和埃默里大学（Emory University）的3所学校的29名核心成员组成，包括医学院，公共卫生学院和埃默里学院。 CGE计划成员目前拥有15,110,592美元的研究赠款资金（年度直接费用），其中12,849,105美元是同行评审，4,277,290美元（34％）是NCI资助的。计划成员在CUN-ENT项目期间发表了227个与癌症相关的出版物。其中，有12％和25％分别代表了跨间隙和相互作用。在当前的项目时期，发现工作导致了关键基因的鉴定，其突变或表达改变会导致癌症的启动和进展。癌症表观遗传学领域的基本发现促使早期的小分子筛查工作以鉴定新的靶向剂。计划的开发和关键募集已加强并增强了人类辐射致癌，DNA损伤/修复和癌症基因组学领域的概括性活动。这已被利用为几个新的多侵略器补助金，并通过增加程序间活动和跨记录基因组学计划为该计划提供了关键的转化途径。成功的基因组研究导致肿瘤的分子分类和基因的鉴定。前列腺，乳房，大脑和肺部恶性肿瘤的特征和临床因素。癌症遗传学和表观遗传学计划促进了科学合作和癌症研究发现，并在即将到来的项目时期定位了持续发展。