2010 FASEB Conference "Biological Methylation:From DNA to Histones and Beyond"

2010年FASEB会议“生物甲基化：从DNA到组蛋白及其他”

• 批准号: 7911239
• 负责人: Paula M. Vertino
• 金额: $ 0.7万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7911239
• 关键词: American; Area; Behavioral; Biological; Biological Process; Biology; Cell physiology; Chemicals; DNA; DNA Damage; DNA Methylation; Development; Disease; Enzymatic Biochemistry; Epigenetic Process; Evolution; Funding; Gene Expression; Genome; Genome Stability; Goals; Histones; Institution; Malignant Neoplasms; Methylation; Modification; Participant; Pattern; Play; Postdoctoral Fellow; Protein Methyltransferases; Proteins; Reading; Request for Proposals; Research; Research Personnel; Resort; Role; Scientist; Senior Scientist; Societies; Stress; Structure; Technology; Time; Transcriptional Regulation; abstracting; base; graduate student; human disease; macromolecule; meetings; posters; public health relevance; response; symposium

DESCRIPTION (provided by applicant): This proposal seeks partial support for the 2010 Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference on "Biological Methylation: From DNA to Histones and Beyond". This will be the ninth biennial conference on this topic and will be held from June 6-11, 2010 at the Carefree Resort in Carefree AZ. The "Biological Methylation" conference has historically taken a unique approach in its integrative coverage of the enzymology, function, and recognition of S-adenosylmethionine- dependent methylation and its influence on diverse biological processes and disease. Over the last sixteen years, this meeting has evolved a particular focus on topics relating to DNA and histone methylation, and the role of these epigenetic modifications in development and disease. Recent advances in the areas of epigenetic reprogramming, which involves the resetting of DNA and histone methylation patterns during development and disease, and the evolution of genome-scale technologies to comprehensively evaluate DNA methylation and histone methylation have put this field at the forefront of modern biology. A major focus of the conference will be the influence of epigenetic (DNA, histone) methylation on gene expression and genome stability, and the contribution of dysregulated methylation to human diseases, particularly cancer. New to this meeting is an emphasis on epigenetic 'reprogramming' and the contribution of DNA and protein methylation in the cellular /behavioral responses to environmental stress. Other sessions deal with the structure and function of DNA and protein methyltransferases/ demethylases, and the posttranslational methylation of non-histone proteins, which has emerged as an exciting new area of study, with central roles in the regulation of transcription and the DNA damage response. This conference is attended by a diverse group of junior and senior scientists from a range of academic and research institutions in the US and abroad. A major goal of the meeting is to promote interaction between junior scientists (postdoctoral fellows, graduate students) and more senior established investigators. The conference format includes nine plenary sessions (36 invited speakers), two "Recent Advances" minisymposia (consisting of 12 speakers selected from submitted abstracts), and two poster sessions. Ample time will be provided for the 120-150 expected participants to socialize and interact on an informal basis. PUBLIC HEALTH RELEVANCE: Cellular macromolecules such as DNA and proteins are frequently modified with a small chemical tag called 'methylation'. This modification plays a fundamental role in determining how the genome is packaged and read, and how proteins act together to carry out cellular functions. Patterns of methylation are strictly controlled during development and alterations in epigenetic methylation contribute to human disease, particularly cancer. The proposal requests partial funding for a conference entitled "Biological Methylation: from DNA to Histones and Beyond ". Approximately 150 scientists will attend to coordinate, exchange, and disseminate information on the underlying mechanisms controlling epigenetic methylation and to explore the contribution of dysregulated methylation to human disease.

描述（由申请人提供）：该提案寻求对2010年美国实验生物学联合会（FASEB）夏季研究会议“生物甲基化：从DNA到HASTONES及其他地区”的部分支持。这将是有关该主题的第九届双年展会议，将于2010年6月6日至11日在Carefree Az的无忧无虑的度假胜地举行。 历史上，“生物甲基化”会议在其对S-腺苷甲基氨基氨酸依赖性甲基化的酶学，功能和识别及其对多样化生物过程和疾病的影响方面的综合覆盖范围一直采取了独特的方法。在过去的十六年中，这次会议已发展到与DNA和组蛋白甲基化有关的主题，以及这些表观遗传修饰在发育和疾病中的作用。表观遗传重编程领域的最新进展，涉及在发育和疾病期间重置DNA和组蛋白甲基化模式，以及基因组规模技术的演变以全面评估DNA甲基化和组蛋白甲基化，这使该领域成为现代生物学的最前沿。 会议的主要重点是表观遗传学（DNA，组蛋白）对基因表达和基因组稳定性的影响，以及甲基化失调对人类疾病（尤其是癌症）的贡献。这次会议的新内容强调表观遗传“重编程”以及DNA和蛋白甲基化在细胞 /行为反应对环境应激的反应中的贡献。其他课程涉及DNA和蛋白甲基转移酶/去甲基酶的结构和功能，以及非固定蛋白的翻译后甲基化，这已成为令人兴奋的新研究领域，在转录调节和DNA损伤反应中具有核心作用。 来自美国和国外的一系列学术和研究机构的一群初级和高级科学家参加了这次会议。会议的主要目标是促进初级科学家（博士后研究员，研究生）和更多高级成熟研究人员之间的互动。会议格式包括九个全体会议（36个受邀演讲者），两个“最新进展”迷你典礼（由从提交摘要中选出的12位演讲者组成）和两个海报会议。 120-150名预期的参与者将提供足够的时间，以便以非正式的方式进行社交和互动。 公共卫生相关性：细胞大分子（例如DNA和蛋白质）经常用称为“甲基化”的小化学标签来修饰。这种修饰在确定基因组的包装和阅读方式以及蛋白质如何共同发挥细胞功能方面起着基本作用。在发育过程中严格控制甲基化的模式，表观遗传甲基化的改变会导致人类疾病，尤其是癌症。 该提案要求部分资金为“生物甲基化：从DNA到组蛋白及以后”的会议。大约有150位科学家将参加有关控制表观遗传甲基化的基本机制的协调，交换和传播信息，并探讨甲基化失调对人类疾病的贡献。