Longitudinal Structural MRI Study of Adulthood Outcome in Tourette Syndrome

抽动秽语综合征成年期结局的纵向结构 MRI 研究

• 批准号: 8271406
• 负责人: Michael H Bloch
• 金额: $ 18.08万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8271406
• 关键词: 14 year old; Adolescence; Adolescent; Adult; Affect; Age; American; Area; Attention; Award; Basal Ganglia; Biological Psychiatry; Brain; Characteristics; Child; Childhood; Chronic Disease; Clinic; Clinical; Clinical Research; Clinical assessments; Corpus striatum structure; Development; Diagnosis; Disease; Disease remission; Doctor of Medicine; Epidemiology; Family; Financial compensation; Generations; Gilles de la Tourette syndrome; Goals; Journals; K-Series Research Career Programs; Life; Magnetic Resonance Imaging; Manuscripts; Measures; Mediating; Medical Students; Mentors; Mentorship; Modeling; Molecular; Morphology; Motor; Motor Cortex; Motor Tics; Nature; Neurobiology; Neurology; Neuropsychological Tests; Outcome; Pathogenesis; Patients; Peer Review; Psychiatry; Public Health Schools; Publications; Publishing; Research; Research Personnel; Research Training; Residencies; Scanning; Severities; Surface; Symptoms; Testing; Thick; Training; Training Programs; Uncertainty; Vocal Tics; base; case control; clinical care; cognitive control; cohort; design; experience; follow-up; improved; neuroimaging; neuropsychiatry; novel; prevent; prognostic; programs; public health relevance; research clinical testing; trait; young adult

DESCRIPTION (provided by applicant): Tourette syndrome (TS) is a childhood-onset neuropsychiatric disorder. In over half of cases tics improve or remit during adolescence. However, the most severe symptoms of TS are usually seen in adulthood. In this career development award we will conduct a longitudinal structural neuroimaging that follows children with TS to young adulthood. Our goal is to compare the brain development in persistent TS cases to remitted cases and unaffected controls. Michael H. Bloch, M.D., M.S., the candidate for this career development award, has spent the last 10 years researching and treating TS and related disorders at Yale first as a medical student and then in psychiatry residency. He will complete his child and adult psychiatry training in the Albert J., Solnit Integrated Training Program at the Yale Child Study Center in June 2010. The Albert J. Solnit Training Program is a novel combined six-year child and adult psychiatry residency program that combines clinical and research training. Based on his clinical expertise, he was appointed as Assistant Director of the Yale OCD Clinic after his third year of residency. He has also completed a graduate degree in chronic disease epidemiology from the Yale School of Public Health during his residency program. He has already published over 20 peer-reviewed publications in TS and related disorder during his residency training including first-authored publications in the American Journal of Psychiatry, Molecular Psychiatry, JAACAP, Neurology and Biological Psychiatry. The majority of these articles were published under the mentorship of James F. Leckman M.D. and Bradley S. Peterson, M.D., who are the proposed mentors for this K award. The candidate plans to become an independent investigator in developmental neuroimaging of TS and related disorders at the completion of his awards period. He plans to get training and mentorship in structural neuroimaging during the career development award period. We have followed a cohort of 46 children diagnosed with TS to young adulthood. Each of these children received a detailed clinical assessment, structural neuroimaging and focused neuropsychological testing prior to age 14 years. We have published several manuscripts on this demonstrated in this cohort that smaller childhood caudate volumes were associated with increased tic symptoms in young adulthood. Our goals are to (1) examine the association of childhood basal ganglia morphology and childhood cortical thickness measures and adulthood tic severity and (2) repeat structural neuroimaging scans on these subjects so that we can compare brain development between persistent TS cases, remitted TS cases and unaffected controls. PUBLIC HEALTH RELEVANCE: Over half of children with Tourette syndrome (TS) improve or remit during adolescence. However, the most severe cases of TS are usually seen in adulthood. We will conduct a longitudinal structural neuroimaging that follows children with Tourette syndrome to young adulthood with the goal of comparing brain development between persistent TS cases to TS remitted cases and unaffected controls.

描述（由申请人提供）：抽动秽语综合症（TS）是一种儿童期发病的神经精神疾病。超过一半的病例抽动症在青春期会改善或缓解。然而，最严重的 TS 症状通常出现在成年期。在这个职业发展奖中，我们将进行纵向结构神经成像，跟踪患有 TS 的儿童到成年早期。我们的目标是将持续性 TS 病例与缓解病例和未受影响的对照组的大脑发育进行比较。 Michael H. Bloch，医学博士、理学硕士，该职业发展奖的候选人，过去 10 年一直在耶鲁大学研究和治疗 TS 及相关疾病，首先是作为一名医学生，然后是精神病学住院医师。他将于 2010 年 6 月在耶鲁儿童研究中心的 Albert J. Solnit 综合培训计划中完成儿童和成人精神病学培训。Albert J. Solnit 培训计划是一项新颖的六年儿童和成人精神病学住院医师培训计划。结合临床和研究培训。基于他的临床专业知识，他在住院医师实习第三年后被任命为耶鲁强迫症诊所的助理主任。他还在住院医师计划期间完成了耶鲁大学公共卫生学院慢性病流行病学的研究生学位。在住院医师培训期间，他已经发表了 20 多篇有关 TS 和相关疾病的同行评审出版物，其中包括在《美国精神病学杂志》、《分子精神病学》、《JAACAP》、《神经病学》和《生物精神病学》上发表的第一作者出版物。这些文章大部分是在 James F. Leckman 医学博士和 Bradley S. Peterson 医学博士的指导下发表的，他们是本次 K 奖的拟议导师。该候选人计划在获奖期结束后成为 TS 和相关疾病的发育神经影像学的独立研究者。他计划在职业发展奖励期间接受结构神经影像学的培训和指导。 我们对 46 名被诊断患有 TS 的儿童进行了跟踪调查，直至成年。这些儿童在 14 岁之前都接受了详细的临床评估、结构神经影像学和重点神经心理学测试。我们已经就此发表了几篇手稿，证明该队列中较小的儿童尾状核体积与成年早期抽动症状的增加有关。我们的目标是 (1) 检查儿童基底神经节形态和儿童皮质厚度测量值与成年抽动严重程度之间的关联，以及 (2) 对这些受试者重复进行结构神经影像扫描，以便我们可以比较持续性 TS 病例和缓解 TS 病例之间的大脑发育和不受影响的控制。 公共卫生相关性：超过一半的抽动秽语综合征 (TS) 儿童在青春期期间病情有所改善或缓解。然而，最严重的 TS 病例通常出现在成年期。我们将进行纵向结构神经影像学检查，追踪抽动秽语综合症儿童至成年早期的情况，目的是比较持续性抽动秽语综合征病例、抽动秽语综合征缓解病例和未受影响对照组之间的大脑发育情况。