Longitudinal Structural MRI Study of Adulthood Outcome in Tourette Syndrome

抽动秽语综合征成年期结局的纵向结构 MRI 研究

• 批准号: 7957516
• 负责人: Michael H Bloch
• 金额: $ 18.07万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7957516
• 关键词: 14 year old; Adolescence; Adolescent; Adult; Affect; Age; American; Area; Attention; Award; Basal Ganglia; Biological Psychiatry; Brain; Characteristics; Child; Childhood; Chronic Disease; Clinic; Clinical; Clinical Research; Clinical assessments; Corpus striatum structure; Development; Diagnosis; Disease; Disease remission; Doctor of Medicine; Epidemiology; Family; Financial compensation; Generations; Gilles de la Tourette syndrome; Goals; Journals; K-Series Research Career Programs; Life; Magnetic Resonance Imaging; Manuscripts; Measures; Mediating; Medical Students; Mentors; Mentorship; Modeling; Molecular; Morphology; Motor; Motor Cortex; Nature; Neurobiology; Neurology; Neuropsychological Tests; Outcome; Pathogenesis; Patients; Peer Review; Psychiatry; Public Health Schools; Publications; Publishing; Research; Research Personnel; Research Training; Residencies; Scanning; Severities; Surface; Symptoms; Testing; Thick; Training; Training Programs; Uncertainty; Vocal Tics; base; case control; clinical care; cognitive control; cohort; design; experience; follow-up; improved; neuroimaging; neuropsychiatry; novel; prevent; prognostic; programs; public health relevance; research clinical testing; trait; young adult

DESCRIPTION (provided by applicant): Tourette syndrome (TS) is a childhood-onset neuropsychiatric disorder. In over half of cases tics improve or remit during adolescence. However, the most severe symptoms of TS are usually seen in adulthood. In this career development award we will conduct a longitudinal structural neuroimaging that follows children with TS to young adulthood. Our goal is to compare the brain development in persistent TS cases to remitted cases and unaffected controls. Michael H. Bloch, M.D., M.S., the candidate for this career development award, has spent the last 10 years researching and treating TS and related disorders at Yale first as a medical student and then in psychiatry residency. He will complete his child and adult psychiatry training in the Albert J., Solnit Integrated Training Program at the Yale Child Study Center in June 2010. The Albert J. Solnit Training Program is a novel combined six-year child and adult psychiatry residency program that combines clinical and research training. Based on his clinical expertise, he was appointed as Assistant Director of the Yale OCD Clinic after his third year of residency. He has also completed a graduate degree in chronic disease epidemiology from the Yale School of Public Health during his residency program. He has already published over 20 peer-reviewed publications in TS and related disorder during his residency training including first-authored publications in the American Journal of Psychiatry, Molecular Psychiatry, JAACAP, Neurology and Biological Psychiatry. The majority of these articles were published under the mentorship of James F. Leckman M.D. and Bradley S. Peterson, M.D., who are the proposed mentors for this K award. The candidate plans to become an independent investigator in developmental neuroimaging of TS and related disorders at the completion of his awards period. He plans to get training and mentorship in structural neuroimaging during the career development award period. We have followed a cohort of 46 children diagnosed with TS to young adulthood. Each of these children received a detailed clinical assessment, structural neuroimaging and focused neuropsychological testing prior to age 14 years. We have published several manuscripts on this demonstrated in this cohort that smaller childhood caudate volumes were associated with increased tic symptoms in young adulthood. Our goals are to (1) examine the association of childhood basal ganglia morphology and childhood cortical thickness measures and adulthood tic severity and (2) repeat structural neuroimaging scans on these subjects so that we can compare brain development between persistent TS cases, remitted TS cases and unaffected controls. PUBLIC HEALTH RELEVANCE: Over half of children with Tourette syndrome (TS) improve or remit during adolescence. However, the most severe cases of TS are usually seen in adulthood. We will conduct a longitudinal structural neuroimaging that follows children with Tourette syndrome to young adulthood with the goal of comparing brain development between persistent TS cases to TS remitted cases and unaffected controls.

描述（由申请人提供）：Tourette综合征（TS）是一种儿童期神经精神疾病。在超过一半的情况下，在青春期，抽动会改善或汇率。但是，TS的最严重症状通常在成年中出现。在这个职业发展奖中，我们将进行纵向结构性神经影像学，跟随TS到年轻人的儿童。我们的目标是将持续的TS病例中的大脑发育与汇总案件和未受影响的控制措施进行比较。 迈克尔·H·布洛赫（Michael H.他将于2010年6月在耶鲁儿童研究中心的索尔尼特综合培训计划的阿尔伯特·J。（Albert J.根据他的临床专业知识，他在居住第三年后被任命为耶鲁大学OCD诊所的助理主任。他还完成了耶鲁大学公共卫生学院居住计划期间的慢性病流行病学研究生学位。在他的住院医师培训期间，他已经发表了20多个在TS和相关疾病中的同行评审出版物，其中包括《美国精神病学杂志》，《分子精神病学杂志》，《 Jaacap，jaacap》，《神经病学和生物精神病学》中的首次出版物。这些文章中的大多数是在詹姆斯·莱克曼（James F.候选人计划在颁奖期结束时成为TS和相关疾病发展神经影像学的独立研究者。他计划在职业发展奖期间获得结构性神经影像学的培训和指导。 我们遵循了46名被诊断为TS的儿童到成年。这些孩子中的每一个都接受了14岁以前的详细临床评估，结构性神经影像学和重点的神经心理学测试。我们已经在这一队列中发表了几本手稿，表明较小的童年尾状体积与成年年轻人的TIC症状增加有关。我们的目标是（1）检查儿童基底神经节形态与儿童期皮层厚度度量和成年期严重程度的关联，以及（2）在这些受试者上重复进行结构性神经影像学扫描，以便我们可以在持续的TS病例之间比较大脑的脑发育，从而将TS案例恢复，恢复TS病例和未受到影响的控制。 公共卫生相关性：超过一半的Tourette综合征（TS）在青春期改善或汇聚。但是，最严重的TS病例通常在成年中出现。我们将进行纵向结构性神经影像学，跟踪有Tourette综合征的儿童至年轻的成年儿童，其目的是将持续的TS病例与TS汇款案件和不受影响的控制措施进行比较。