Growth Control and Genomic Stability

生长控制和基因组稳定性

基本信息

批准号：
7944583
负责人：
Geoffrey Myles Wahl
金额：
$ 2.57万
依托单位：
SALK INSTITUTE FOR BIOLOGICAL STUDIES
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-14 至 2013-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7944583
关键词：
1-Phosphatidylinositol 3-Kinase Adenoviruses Affect Amino Acids Apoptotic Award BRCA1 gene Biology Budgets Cancer Center Support Grant Cell Aging Cell Cycle Cell Cycle Regulation Cell Proliferation Cell Size Cells Chlamydomonas Chromatin Chromatin Modeling Chromosomes DNA Damage DNA Double Strand Break Development Direct Costs Functional disorder Gene Expression Regulation Genetic Genome Stability Genomic Instability Genomics Goals Grant Growth Homeostasis Human Laboratories Libraries Light Maintenance Malignant Neoplasms Mediating Membrane Methods Mitosis Modeling Modification Mutation Nuclear Pore Nuclear Receptors Oncogenic Oncolytic Organism Pathway interactions Peer Review Play Process Protein p53 Proteins Publications Regulation Regulation of Cell Size Research Resected Role Signal Pathway Signal Transduction Small Interfering RNA Somatic Cell Stem cells Stress System TP53 gene Telomerase Therapeutic Trans-Activators Transcriptional Regulation Translating Tumor Suppressor Proteins Ubiquitination Viral Virus Yeasts biological adaptation to stress cancer cell cancer type cell type chromatin modification crosslink genome-wide homologous recombination human FRAP1 protein in vivo interest member mouse model mutant neoplastic cell novel therapeutics nuclease prevent programs reconstitution repaired response telomere

项目摘要

The scientific goals and central themes of the Growth Control and Genomic Stability Program are to understand mechanisms of proliferation and cell size regulation, transcriptional regulation of oncogenic signaling pathways, DMA damage response, maintenance of genomic integrity and telomere function, and how these processes are disrupted in cancer cells. The program includes ten members from six different laboratories: Beverly Emerson (transcriptional regulation by the p53 tumor suppressor), Martin Hetzer (nuclear pore assembly mechanisms and cancer), Katherine Jones (Wnt/p-catenin signaling pathways and transcriptional regulation), Jan Karlseder (telomere function and dysregulation in cancer cells), Vicki Lundblad (telomere regulation in yeast), Clodagh O'Shea (oncolytic adenoviruses and adenovirus-targeted proliferation pathways), James Umen (RB pathway*" regulation and cell size in Chlamydomonas), Geoffrey Wahl (p53 stress response pathway), Lei Wang (unnatural amino acid incorporation in tumor cells and stem cells), and Matthew Weitzman (host cell DNA damage response systems abrogated by viruses). The total amount of peer-reviewed support (direct costs) for the last budget year was $3,325,741. Of this amount, $920,040 was awarded by the NCI. The total number of publications by members of this program in the last grant period (2004-2008) was 132. Of the total publications, 3% were intraprogrammatic and 11% were interprogrammatic (see Section 8 for explanation of how the program reorganization affects these numbers).

生长控制和基因组稳定性计划的科学目标和中心主题是了解增殖和细胞大小调节、致癌转录调节的机制信号通路、DMA 损伤反应、基因组完整性和端粒功能的维持，以及这些过程在癌细胞中是如何被破坏的。该计划包括来自六个不同实验室的十名成员： Beverly Emerson（转录 p53 肿瘤抑制因子的调节），Martin Hetzer（核孔组装机制和癌症）， Katherine Jones（Wnt/p-catenin 信号通路和转录调控）、Jan Karlseder（端粒）癌细胞中的功能和失调），Vicki Lundblad（酵母中的端粒调节），Clodagh O'Shea （溶瘤腺病毒和腺病毒靶向增殖途径），James Umen（RB途径*" 衣藻中的调节和细胞大小），Geoffrey Wahl（p53 应激反应途径），Lei Wang （肿瘤细胞和干细胞中的非天然氨基酸掺入）和 Matthew Weitzman（宿主细胞 DNA 损害反应系统被病毒废除）。上一个预算年度的同行评审支持总额（直接费用）为 3,325,741 美元。其中的 NCI 授予了 920,040 美元的奖金。该计划成员在上一个资助期间（2004-2008 年）的出版物总数为 132 篇。在所有出版物中，3% 是程序内出版物，11% 是程序间出版物（请参阅第 8 节了解解释程序重组如何影响这些数字）。