Pilot Projects

试点项目

基本信息

批准号：
8375834
负责人：
DOUGLAS A LAUFFENBURGER
金额：
$ 12.28万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-04-17 至 2015-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8375834
关键词：
1-Phosphatidylinositol 3-Kinase Actins Address Affect Antibodies Behavior Binding Biological Assay Calibration Cell Communication Cell physiology Cells Cleaved cell Collaborations Color Communities Complement Complex Computer Simulation DNA Damage Data Direct Costs Disintegrins Dyes Engineering Environment Epidermal Growth Factor Receptor Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Event Extracellular Matrix Degradation Feedback Film Fluorescence Fluorescence Microscopy Funding Glycogen (Starch) Synthase Goals Grant Growth Factor Growth Factor Receptors Human Resources In Vitro Individual Laboratories MEKs Matrix Metalloproteinases Measurement Measures Mediating Metalloproteases Methods Microarray Analysis Modeling Nature Neoplasm Metastasis Pathway interactions Peptide Hydrolases Peptides Phenotype Phospho-Specific Antibodies Phosphorylation Pilot Projects Polymers Preclinical Drug Evaluation Process Progress Reports Protease Inhibitor Protein Microchips Proteins Proto-Oncogene Proteins c-akt Publishing Pyroxylin Reagent Recording of previous events Relative (related person)Research Research Personnel Sampling Science Signal Pathway Signal Transduction Slide Specificity Spottings Stimulation of Cell Proliferation Substrate Specificity Surface System Techniques Time Tissues Tumor Cell Invasion U-0126 Variant Western Blotting Work antibody conjugate base cell growth regulation cell motility chemokine cytokine design enzyme activity extracellular fluorophore inhibitor/antagonist interest kinase inhibitor malignant breast neoplasm migration neoplastic cell novel strategies polypeptide programs research study response sensor technology development therapeutic target tool tumor wortmannin

项目摘要

N4F. PILOT PROJECTS We typically aim to provide catalytic funding for two Pilot projects during each grant year. Pilot projects are funded for a period of two years at a level in the range of ~$6oK-9oK direct costs per year. The level depends on the extent of personnel and materials/supplies requirement for gaining preliminary results, and the time period permits assessment of how well the science and investigators integrate into the ongoing Projects or Core. The Pilot projects are selected by the Steering Committee from applications submitted by investigators in the MIT (and Harvard) communities, on the basis of potential for providing powerful new approaches that complement overall program aims. If deemed highly successful in collaborative integration, the Pilot investigator(s) can become regular PIs in the Projects or Core. During the previous grant period, Pilots directed by Ernest Fraenkel and Mike Hemann have done so, with results described in the Progress Report section and plans described in the Research Plans section for their corresponding Project and Core participation. The two Pilots intended for Year 6 of the grant if successfully renewed are presented below.

N4F。试点项目我们通常的目标是在每个拨款年度为两个试点项目提供催化资金。试点项目有资助期限为两年，每年直接成本约为 6 至 9 美元。水平取决于获得初步结果所需的人员和材料/用品的范围以及时间期间允许评估科学和研究人员融入正在进行的项目或核。试点项目由指导委员会从研究者提交的申请中选出在麻省理工学院（和哈佛大学）社区中，基于提供强大新方法的潜力补充总体计划目标。如果认为协作集成非常成功，则试点研究者可以成为项目或核心中的常规 PI。在上一个拨款期间，飞行员由 Ernest Fraenkel 和 Mike Hemann 指导的人已经这样做了，其结果在进度报告中进行了描述部分以及研究计划部分中描述的相应项目和核心的计划参与。如果成功续签，计划在第 6 年进行的两个试点项目如下所示。