MOMI Administrative Core

MOMI 管理核心

• 批准号: 10611520
• 负责人: DOUGLAS A LAUFFENBURGER
• 金额: $ 17.4万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-19 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10611520
• 关键词: Accountability; Affect; Agreement; Atlases; Autoimmune Diseases; COVID-19 pandemic; Clinical; Clinical Management; Collaborations; Communication; Data; Data Analyses; Data Set; Development; Ensure; Epidemic; Evolution; Exclusion; Feedback; Goals; Immune; Immune response; Immunity; Immunologic Surveillance; Immunologics; Immunology; Infant; Infection; Influenza; Investigation; Leadership; Legal; Link; Maternal-fetal medicine; Measures; Mentorship; Nature; Performance; Pertussis; Play; Population; Predisposition; Pregnancy; Pregnant Women; Privatization; Program Evaluation; Progress Reports; Recording of previous events; Research Personnel; Resources; Role; Running; Safety; Sampling; Shapes; Site Visit; Systems Biology; Training Support; Translating; United States National Institutes of Health; Vaccination; Vaccine Design; Vaccines; Visit; Vulnerable Populations; Woman; Work; ZIKA; cohesion; conflict resolution; coronavirus disease; data dissemination; data integration; data management; data sharing; design; digital; fetal; immunosuppressed; innovation; novel therapeutics; novel vaccines; outreach; programs; sample collection; success; timeline; tool; vaccine development; vaccine response; vaccine strategy; vaccine trial

Administrative Core: Summary Pregnancy represents a unique immunological state that has been largely overlooked for decades in the field of immunology. This HIPC program aims to support the deep immunological characterization and investigation of immunity during pregnancy to inspire next generation vaccine development to protect this unique segment of the global population that are more vulnerable to infection. The Administrative Core (AC) will play a critical central role in shaping the success of the overall program offering administrative, structural, and clinical support to the program, nucleating all efforts as well as performing the necessary outreach to collaborators, funders, and public/private partners. The AC will create digital and live platforms for the free exchange of scientific information, will serve to facilitate access to samples and data, will support the acquisition of samples for the program, will support legal agreements for sample and data sharing, will support training/mentorship, and will function in financial and programmatic management to ensure the success of the overall program. In addition, the AC will coordinate participation in program evaluation activities, including progress reports, site visits, and provide additional communication and materials to the NIH as needed. Finally, the AC will also function to maintain interactive practices that maintain cohesion across the team as well as the entire HIPC, ensuring that all investigators are engaged in the overall success of the program and ultimately into translating findings for the development of truly innovative products to reshape vaccine development for pregnancy and other immunosuppressed populations.

行政核心：摘要 怀孕代表了一种独特的免疫状态，数十年来一直被忽略了 免疫学领域。该HIPC计划旨在支持深层的免疫学特征和 怀孕期间免疫的调查以激发下一代疫苗开发以保护这种独特的 全球人口的细分市场更容易受到感染的影响。行政核心（AC）将播放 在塑造提供行政，结构和临床的整体计划成功方面的关键核心作用 支持该计划，将所有努力成核以及向合作者进行必要的宣传， 资助者和公共/私人合作伙伴。 AC将创建数字和实时平台，以免费交换 科学信息将有助于访问样品和数据，将支持样本的获取 对于该计划，将支持用于样本和数据共享的法律协议，将支持培训/指导，并 将在财务和程序管理中发挥作用，以确保整体计划的成功。此外， AC将协调参与计划评估活动，包括进度报告，现场访问和 根据需要为NIH提供其他沟通和材料。最后，交流也将运行 维护互动实践，以维持整个团队以及整个HIPC的凝聚力，以确保 所有调查人员都均参与了该计划的整体成功，并最终转化了 开发真正创新的产品，以重塑疫苗的妊娠和其他产品 免疫抑制人群。