MOMI Administrative Core

MOMI 管理核心

• 批准号: 10420107
• 负责人: DOUGLAS A LAUFFENBURGER
• 金额: $ 47.08万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-19 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10420107
• 关键词: Accountability; Affect; Agreement; Atlases; Autoimmune Diseases; COVID-19 pandemic; Clinical; Clinical Management; Collaborations; Communication; Data; Data Analyses; Data Set; Development; Ensure; Epidemic; Evolution; Feedback; Goals; Immune; Immune response; Immunity; Immunologic Surveillance; Immunologics; Immunology; Infant; Infection; Influenza; Investigation; Leadership; Legal; Link; Maternal-fetal medicine; Measures; Mentorship; Nature; Performance; Pertussis; Play; Population; Pregnancy; Pregnant Women; Privatization; Program Evaluation; Progress Reports; Recording of previous events; Research Personnel; Resources; Role; Running; Safety; Sampling; Shapes; Site Visit; Systems Biology; TimeLine; Training Support; Translating; United States National Institutes of Health; Vaccination; Vaccine Design; Vaccines; Visit; Vulnerable Populations; Woman; Work; ZIKA; cohesion; conflict resolution; coronavirus disease; data dissemination; data integration; data management; data sharing; design; digital; fetal; immunosuppressed; innovation; novel therapeutics; novel vaccines; outreach; programs; sample collection; success; tool; vaccine development; vaccine response; vaccine strategy; vaccine trial

Administrative Core: Summary Pregnancy represents a unique immunological state that has been largely overlooked for decades in the field of immunology. This HIPC program aims to support the deep immunological characterization and investigation of immunity during pregnancy to inspire next generation vaccine development to protect this unique segment of the global population that are more vulnerable to infection. The Administrative Core (AC) will play a critical central role in shaping the success of the overall program offering administrative, structural, and clinical support to the program, nucleating all efforts as well as performing the necessary outreach to collaborators, funders, and public/private partners. The AC will create digital and live platforms for the free exchange of scientific information, will serve to facilitate access to samples and data, will support the acquisition of samples for the program, will support legal agreements for sample and data sharing, will support training/mentorship, and will function in financial and programmatic management to ensure the success of the overall program. In addition, the AC will coordinate participation in program evaluation activities, including progress reports, site visits, and provide additional communication and materials to the NIH as needed. Finally, the AC will also function to maintain interactive practices that maintain cohesion across the team as well as the entire HIPC, ensuring that all investigators are engaged in the overall success of the program and ultimately into translating findings for the development of truly innovative products to reshape vaccine development for pregnancy and other immunosuppressed populations.

行政核心：摘要 怀孕代表了一种独特的免疫状态，几十年来一直被忽视。 免疫学领域。该 HIPC 计划旨在支持深度免疫学特征和 对怀孕期间的免疫力进行调查，以激发下一代疫苗的开发，以保护这一独特的 全球人口中更容易受到感染的部分。行政核心（AC）将发挥作用 在提供行政、结构和临床的整个计划的成功方面发挥着关键的核心作用 支持该计划，集中所有努力并对合作者进行必要的外展， 资助者和公共/私人合作伙伴。 AC 将创建数字和实时平台，以便自由交流 科学信息，将有助于促进样品和数据的获取，将支持样品的采集 对于该计划，将支持样本和数据共享的法律协议，将支持培训/指导，以及 将负责财务和计划管理，以确保整个计划的成功。此外， 审计委员会将协调参与计划评估活动，包括进度报告、实地考察和 根据需要向 NIH 提供额外的沟通和材料。最后，AC 还将发挥以下作用： 保持互动实践，以保持整个团队以及整个重债穷国的凝聚力，确保 所有研究人员都致力于该计划的整体成功，并最终将研究结果转化为 开发真正创新的产品，重塑妊娠期和其他疾病的疫苗开发 免疫抑制人群。