COMPARING GLYCANS OF HER-2 MOUSE MAMMARY TUMORS TO NON-DISEASED MAMMARY TISSUE

HER-2 小鼠乳腺肿瘤与非患病乳腺组织的聚糖的比较

• 批准号: 8363121
• 负责人: J. Michael Pierce
• 金额: $ 0.34万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363121
• 关键词: ERBB2 gene; Funding; Grant; Link; Mammary Neoplasms; Mammary gland; Mus; National Center for Research Resources; Polysaccharides; Principal Investigator; Research; Research Infrastructure; Resources; Source; Structure; Technology; Tissues; United States National Institutes of Health; cancer stem cell; cost; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We have recently shown that GnT-V expression levels regulate the mouse mammary cancer stem cell compartment resulting from her-2 over-expression. In addition, we have shown that glycans that are products of GnT-V are found in different levels on the her-2 receptor when the activity of GnT-V is modulated. We are now determining the precise structures of the N-linked glycans on the mammary tumors induced by her-2 and comparing those quantitatively with the structures expressed in the non-diseased mammary gland.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 我们最近发现，GnT-V 表达水平可调节由于 her-2 过度表达而产生的小鼠乳腺癌干细胞区室。 此外，我们还发现，当 GnT-V 的活性受到调节时，her-2 受体上会发现不同水平的 GnT-V 产物聚糖。 我们现在正在确定 her-2 诱导的乳腺肿瘤上 N 连接聚糖的精确结构，并将这些结构与未患病乳腺中表达的结构进行定量比较。