IDENTIFICATION OF A PANCREATIC CARCINOMA-SPECIFIC N-LINKED GLYCAN EPITOPE

胰腺癌特异性 N 联聚糖表位的鉴定

• 批准号: 8363124
• 负责人: J. Michael Pierce
• 金额: $ 0.34万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363124
• 关键词: Adenocarcinoma; Binding; Cells; Epitopes; Funding; Goals; Grant; Link; Malignant neoplasm of pancreas; Monoclonal Antibodies; National Center for Research Resources; Pancreas; Pancreatic carcinoma; Pancreatitis; Peptide N-Glycosidase; Polysaccharides; Principal Investigator; Research; Research Infrastructure; Resources; Source; Technology; Tissues; United States National Institutes of Health; cost; pancreatic cancer cells

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this subproject is to identify the epitope recognized on pancreatic cancer cells that is recognized by the monoclonal antibody #109. This epitope shows specific binding for various adenocarcinomas, including pancreatic cells, and is unreactive to pancreatitis and control tissues. The epitope is sensitive to N-glycanase and is expressed on CEACAM6 uniquely in pancreatic cancer tissues.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 该副本的目的是识别在胰腺癌细胞上识别的表位，而胰腺癌细胞被单克隆抗体＃109识别。 该表位显示了包括胰腺细胞在内的各种腺癌的特异性结合，并且对胰腺炎和对照组织没有反应。 表位对N-聚糖酶敏感，并在胰腺癌组织中独特地在CEACAM6上表达。