BENIGN-MALIGNANT LESION DIFFERENTIATION USING FUNCTIONAL ADC-THRESHOLDING

使用功能性 ADC 阈值区分良恶性病变

• 批准号: 8362919
• 负责人: JOHANNES D VELDHUIS
• 金额: $ 1.95万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362919
• 关键词: Annual Reports; Benign; Blood Vessels; Cystic Lesion; Data Set; Diagnosis; Diffusion weighted imaging; Discrimination; Evaluation; Funding; Grant; Health Insurance Portability and Accountability Act; Hospitals; Image; Institutional Review Boards; Lesion; Magnetic Resonance; Magnetic Resonance Imaging; Malignant - descriptor; Maps; National Center for Research Resources; Pathology; Phase; Physiologic pulse; Predisposition; Principal Investigator; Reading; Research; Research Infrastructure; Resources; Source; Technology; United States National Institutes of Health; Visit; Weight; Woman; abstracting; base; breast lesion; cost; interest; malignant breast neoplasm; patient population; radiologist

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Benign-Malignant Lesion Differentiation Using Functional ADC-Thresholding  Allowing Expert Radiologist Interpretation  Versus Conventional Thresholding Based On ADC Cut-Off Values Diffusion-weighted imaging (DWI) may aid in the discrimination of benign from malignant (breast) lesions. Approaches to benefit from the information contained in the DWI dataset have mostly been based on trying to define a cut-off value for the lesion ADC. This may be limiting because of the relatively low SNR, the relatively high variability of lesion ADC - even within one hospital or patient population - and the limited potential of the results to be extrapolated to different field strengths, pulse-sequences or b-values. We used an approach in which the high CNR of DWI and the quantitative information of the ADC are presented to the radiologist in a "functionally-thresholded ADC (ftADC) map" that increases the conspicuity of lesions of interest, much like phase-images are used to increase vascular conspicuity in susceptibility- weighted imaging. Radiologists can "window-level" ftADC-maps at their discretion and diagnose a lesion as "ftADC-bright" without having to choose an ADC-threshold value; Similar to, for example, a cystic lesion being interpreted as "T2-bright" without using T2-cut-off values. We performed a retrospective, HIPAA-compliant, IRB-approved analysis of DW data sets of 103 consecutive women who underwent 1.5T MRI for the evaluation of breast cancer. Conventional ADC-thresholding was compared to ftADC-mapping and to dynamic contrast-enhanced (DCE) MRI, for all pathology-verified lesions. To read about other projects ongoing at the Lucas Center, please visit http://rsl.stanford.edu/ (Lucas Annual Report and ISMRM 2011 Abstracts)

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 使用功能性ADC阈值允许专家放射科医生解释的良性恶性病变分化 基于ADC截止值而不是常规阈值 扩散加权成像（DWI）可能有助于歧视恶性（乳腺）病变。方法 来自DWI数据集中包含的信息的好处主要是基于试图定义的截止值 病变ADC。由于SNR相对较低，这可能是限制的，病变的变异性相对较高 - 甚至 在一个医院或患者人群中 - 以及将推断到不同领域的结果的有限潜力 优势，脉搏序列或B值。我们使用了一种方法，其中DWI的高CNR和定量 ADC的信息以“功能阈值ADC（FTADC）映射”的形式提供给放射科医生 感兴趣的病变的显着性，就像相似图像一样，用于增加易感性的血管明显 - 加权成像。放射科医生可以自行决定“窗口” ftadc-Maps，并将病变诊断为“ ftadc-bright” 不必选择ADC阈值价值；类似于例如，囊性病变被解释为“ T2-Bright” 不使用t2-cut-off值。我们对DW数据集进行了回顾性，符合HIPAA的符合性IRB批准的分析 103名经过1.5T MRI评估乳腺癌的女性。常规的ADC阈值是 与所有病理验证的病变相比，与FTADC映射和动态对比增强（DCE）MRI相比。 要了解卢卡斯中心正在进行的其他项目，请访问http://rsl.stanford.edu/（卢卡斯年度报告和 ISMRM 2011摘要）