ACCURACY OF HIGH-RESOLUTION MULTI-SHOT DWI FOR THE DETECTION OF BREAST CANCER

高分辨率多次 DWI 检测乳腺癌的准确性

• 批准号: 8362920
• 负责人: JOHANNES D VELDHUIS
• 金额: $ 1.95万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362920
• 关键词: Annual Reports; Breast; Cancer Center; Detection; Diffusion weighted imaging; Funding; Grant; Health Insurance Portability and Accountability Act; Institutional Review Boards; Lesion; Magnetic Resonance; Magnetic Resonance Imaging; National Center for Research Resources; Pathology; Principal Investigator; Reading; Research; Research Infrastructure; Resolution; Resources; Sensitivity and Specificity; Source; Specificity; Techniques; Technology; United States National Institutes of Health; Visit; abstracting; breast cancer diagnosis; cost; improved

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Diffusion-weighted imaging (DWI) may provide information - physically unrelated to microvascular changes detected by contrast-enhanced MRI - that can improve the specificity of MRI for breast cancer diagnosis. Attempts thus far to benefit from the information content that DWI may offer have been limited by the use of single-shot techniques, with inherent sensitivity to geometric distortions and limitations in detected lesion size. The aim of this HIPAA-compliant, IRB-approved study was to compare the sensitivity and specificity of high-resolution DWI of the breast to 'conventional' dynamic-contrast enhanced MRI, and to pathology. To read about other projects ongoing at the Lucas Center, please visit http://rsl.stanford.edu/ (Lucas Annual Report and ISMRM 2011 Abstracts)

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 扩散加权成像（DWI）可能提供信息 - 与检测到的微血管变化无关 对比增强的MRI-可以提高MRI对乳腺癌诊断的特异性。到目前为止的尝试 从DWI可能提供的信息内容受到单发技术的使用限制，并具有固有的 对病变大小的几何扭曲和局限性的敏感性。符合HIPAA的IRB批准的目的 研究是为了比较乳房高分辨率DWI的灵敏度和特异性与“常规”动态对比度 增强了MRI和病理学。 要了解卢卡斯中心正在进行的其他项目，请访问http://rsl.stanford.edu/（卢卡斯年度报告和 ISMRM 2011摘要）