ACCURACY OF HIGH-RESOLUTION MULTI-SHOT DWI FOR THE DETECTION OF BREAST CANCER

高分辨率多次 DWI 检测乳腺癌的准确性

• 批准号: 8362920
• 负责人: JOHANNES D VELDHUIS
• 金额: $ 1.95万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362920
• 关键词: Annual Reports; Breast; Cancer Center; Detection; Diffusion weighted imaging; Funding; Grant; Health Insurance Portability and Accountability Act; Institutional Review Boards; Lesion; Magnetic Resonance; Magnetic Resonance Imaging; National Center for Research Resources; Pathology; Principal Investigator; Reading; Research; Research Infrastructure; Resolution; Resources; Sensitivity and Specificity; Source; Specificity; Techniques; Technology; United States National Institutes of Health; Visit; abstracting; breast cancer diagnosis; cost; improved

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Diffusion-weighted imaging (DWI) may provide information - physically unrelated to microvascular changes detected by contrast-enhanced MRI - that can improve the specificity of MRI for breast cancer diagnosis. Attempts thus far to benefit from the information content that DWI may offer have been limited by the use of single-shot techniques, with inherent sensitivity to geometric distortions and limitations in detected lesion size. The aim of this HIPAA-compliant, IRB-approved study was to compare the sensitivity and specificity of high-resolution DWI of the breast to 'conventional' dynamic-contrast enhanced MRI, and to pathology. To read about other projects ongoing at the Lucas Center, please visit http://rsl.stanford.edu/ (Lucas Annual Report and ISMRM 2011 Abstracts)

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 弥散加权成像 (DWI) 可以提供与微血管检测到的物理变化无关的信息。 对比增强 MRI - 可以提高 MRI 对乳腺癌诊断的特异性。迄今为止尝试受益 从 DWI 可能提供的信息内容来看，由于使用单次技术，固有的 对几何变形的敏感性和检测到的病变大小的限制。该目标符合 HIPAA 标准、IRB 批准 该研究旨在比较乳房高分辨率 DWI 与“传统”动态对比的敏感性和特异性 增强MRI，并进行病理学检查。 要了解卢卡斯中心正在进行的其他项目，请访问 http://rsl.stanford.edu/（卢卡斯年度报告和 ISMRM 2011 摘要）