Detroit Research on Cancer Survivors (Detroit ROCS)

底特律癌症幸存者研究（底特律 ROCS）

• 批准号: 9107577
• 负责人: TERRANCE L ALBRECHT
• 金额: $ 166.67万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-27 至 2022-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9107577
• 关键词: Address; Adherence; Adult; Affect; African American; Aftercare; Alcohol consumption; Annual Reports; Area; Behavioral; Breast; Cancer Burden; Cancer Prognosis; Cancer Survivor; Cancer Survivorship; Caregivers; Caring; Cessation of life; Characteristics; Collection; Colon; Colon Carcinoma; Communities; Community Networks; Comorbidity; Comprehensive Cancer Center; County; Data; Death Records; Depressed mood; Diagnosis; Diet; Disease; Early Diagnosis; Early treatment; Economic Burden; Emotional; Enrollment; Evaluation; Fibrinogen; Frequencies; Funding; Genetic; Grant; Healthcare Systems; Home environment; Incidence; Individual; Length; Lung; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Medical; Medical Record Linkage; Medical Records; Michigan; Minority; National Cancer Institute; Newly Diagnosed; Online Systems; Outcome; Participant; Patient Outcomes Assessments; Patients; Pattern; Phonation; Physical activity; Population; Population-Based Registry; Poverty; Prostate; Provider; Quality of life; Recurrence; Registries; Reporting; Research; Retrieval; SEER Program; Saliva; Severity of illness; Smoking; Social support; Spouse Caregiver; Surveys; System; Telephone; Telephone Interviews; Testing; Treatment outcome; United States; Work; anticancer research; cancer diagnosis; cancer health disparity; cancer type; cohort; community based participatory research; cost; design; experience; family support; follow up assessment; follow-up; improved; indexing; individual patient; malignant breast neoplasm; medically underserved; metropolitan; minority communities; mortality; neoplasm registry; population based; programs; public health relevance; response; social; survival outcome; survivorship; tumor; tumor progression

 DESCRIPTION (provided by applicant): Despite progress made in early detection and treatment, African Americans continue to experience disproportionately higher cancer incidence rates, are first diagnosed with more advanced stage disease, and suffer higher mortality rates than other populations. The determinants of cancer progression, recurrence, mortality and quality of life in African American cancer survivors are not well studied, with biologic, genetic, environmental, social and behavioral factors contributing. The ~25,000 cancers reported annually among residents of metropolitan Detroit provide the basis for a unique cohort of African American cancer survivors that will include cancer types with both poor outcomes overall (lung cancer and colon cancer) and better outcomes overall (breast and prostate cancer) to study both short term and longer term determinants of survival. The cohort will also include caregivers of a subset of the cases to develop research in the areas of family support and economic burden. The specific aims are to: 1) Enroll a total of 5,560 lung, prostate, breast, and colon population-based African American cancer cases into the Detroit Research on Cancer Survivors (Detroit ROCS) cohort. Participation at baseline will include a web-based or telephone interview, saliva collection, and tumor block retrieval. 2) Enroll a total of 2,780 caregivers of these cases. For 50% of the cancer cases, one spouse/caregiver will be asked to participate in a web-based or telephone interview. 3) Conduct yearly follow-up for all cancer cases and their caregivers. 4) Evaluate the need for more frequent follow-up and assessment by collecting patient reported outcome data early in the disease course. This will enable more accurate identification of determinants of outcomes. Most cohorts are followed annually or less often. For this cancer cohort, more frequent follow-up will be tested in a subset of the population to evaluate the most valid and least burdensome strategies for participants to report quality of life data during the fist year post treatment. The resulting population-based, African American cancer cohort will support studies addressing determinants of cancer prognosis and progression, survival, and outcomes of cancer-directed therapies. It will be one of the few cohorts to include a large minority community already actively engaged in cancer research, providing substantial data and biospecimens to facilitate studies aimed at understanding and addressing determinants of poor outcomes in this population. This work will be conducted in the context of a community uniquely engaged through our: 1) Community Network Program Center grant (U54) supporting a community based participatory research (CBPR) approach to addressing cancer disparities; 2) NCI-funded SEER cancer registry for population-based ascertainment of cancer cases in an economically depressed area with a large minority population; and 3) an NCI-designated Comprehensive Cancer Center with a strong transdisciplinary research program in cancer health disparities.

 描述（由适用提供）：尽管在早期检测和治疗方面取得了进展，但非裔美国人仍会继续经历更高的癌症发病率，首先被诊断出患有更晚期的舞台疾病，并且与其他人群相比，死亡率更高。非裔美国人癌症生存中癌症进展，复发，死亡率和生活质量的决定者的研究效果不佳，生物学，遗传，环境，社会和行为因素有助于促成。底特律大都会居民每年报告的约25,000次癌症为非裔美国人癌症生存的独特群体提供了基础，其中包括癌症类型的整体癌症类型（肺癌和结肠癌）较差（肺癌和结肠癌），以及更好的总体结果（乳腺癌和前列腺癌），以研究短期和长期生存的确定者。该队列还将包括一部分案件的护理人员，以在家庭支持和经济伯伦领域进行研究。具体目的是：1）将总共5,560个肺，前列腺，乳腺癌和基于结肠的非裔美国人癌症病例纳入底特律癌症幸存者（底特律ROC）的研究。基线的参与将包括基于网络或电话采访，唾液收集和肿瘤块检索。 2）总共注册了这些案件的2,780名护理人员。 对于50％的癌症病例，将要求一名配偶/照顾者参加基于网络或电话采访。 3）对所有癌症病例及其护理人员进行年度随访。 4）通过收集患者报告的疾病课程中报告的结果数据来评估对更频繁的随访和评估的需求。这将使结果更准确地识别结果。每年或更少遵循大多数队列。对于这种癌症队列，将在一部分人群中进行更频繁的随访，以评估参与者在治疗后拳头一年报告生活质量数据的最有效和最不磨光的策略。由此产生的基于人群的非裔美国癌症队列将支持研究癌症进展和进展，生存和癌症指导疗法结果的决定者。这将是包括已经积极从事癌症研究的大型少数民族社区的少数队列之一，为旨在理解和解决该人群中不良结果的宿主研究提供了大量的数据和生物测量。这项工作将在我们的社区通过我们的独特社区进行：1）社区网络计划中心赠款（U54）支持基于社区的参与研究（CBPR）方法来解决癌症分布； 2）NCI资助的SEER癌症登记处，用于基于人群的癌症病例，在经济沮丧的地区，少数人口较少； 3）NCI指定的综合癌症中心，具有强大的跨学科研究计划。