Detroit Research on Cancer Survivors (Detroit ROCS)

底特律癌症幸存者研究（底特律 ROCS）

• 批准号: 9107577
• 负责人: TERRANCE L ALBRECHT
• 金额: $ 166.67万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-27 至 2022-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9107577
• 关键词: Address; Adherence; Adult; Affect; African American; Aftercare; Alcohol consumption; Annual Reports; Area; Behavioral; Breast; Cancer Burden; Cancer Prognosis; Cancer Survivor; Cancer Survivorship; Caregivers; Caring; Cessation of life; Characteristics; Collection; Colon; Colon Carcinoma; Communities; Community Networks; Comorbidity; Comprehensive Cancer Center; County; Data; Death Records; Depressed mood; Diagnosis; Diet; Disease; Early Diagnosis; Early treatment; Economic Burden; Emotional; Enrollment; Evaluation; Fibrinogen; Frequencies; Funding; Genetic; Grant; Healthcare Systems; Home environment; Incidence; Individual; Length; Lung; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Medical; Medical Record Linkage; Medical Records; Michigan; Minority; National Cancer Institute; Newly Diagnosed; Online Systems; Outcome; Participant; Patient Outcomes Assessments; Patients; Pattern; Phonation; Physical activity; Population; Population-Based Registry; Poverty; Prostate; Provider; Quality of life; Recurrence; Registries; Reporting; Research; Retrieval; SEER Program; Saliva; Severity of illness; Smoking; Social support; Spouse Caregiver; Surveys; System; Telephone; Telephone Interviews; Testing; Treatment outcome; United States; Work; anticancer research; cancer diagnosis; cancer health disparity; cancer type; cohort; community based participatory research; cost; design; experience; family support; follow up assessment; follow-up; improved; indexing; individual patient; malignant breast neoplasm; medically underserved; metropolitan; minority communities; mortality; neoplasm registry; population based; programs; public health relevance; response; social; survival outcome; survivorship; tumor; tumor progression

 DESCRIPTION (provided by applicant): Despite progress made in early detection and treatment, African Americans continue to experience disproportionately higher cancer incidence rates, are first diagnosed with more advanced stage disease, and suffer higher mortality rates than other populations. The determinants of cancer progression, recurrence, mortality and quality of life in African American cancer survivors are not well studied, with biologic, genetic, environmental, social and behavioral factors contributing. The ~25,000 cancers reported annually among residents of metropolitan Detroit provide the basis for a unique cohort of African American cancer survivors that will include cancer types with both poor outcomes overall (lung cancer and colon cancer) and better outcomes overall (breast and prostate cancer) to study both short term and longer term determinants of survival. The cohort will also include caregivers of a subset of the cases to develop research in the areas of family support and economic burden. The specific aims are to: 1) Enroll a total of 5,560 lung, prostate, breast, and colon population-based African American cancer cases into the Detroit Research on Cancer Survivors (Detroit ROCS) cohort. Participation at baseline will include a web-based or telephone interview, saliva collection, and tumor block retrieval. 2) Enroll a total of 2,780 caregivers of these cases. For 50% of the cancer cases, one spouse/caregiver will be asked to participate in a web-based or telephone interview. 3) Conduct yearly follow-up for all cancer cases and their caregivers. 4) Evaluate the need for more frequent follow-up and assessment by collecting patient reported outcome data early in the disease course. This will enable more accurate identification of determinants of outcomes. Most cohorts are followed annually or less often. For this cancer cohort, more frequent follow-up will be tested in a subset of the population to evaluate the most valid and least burdensome strategies for participants to report quality of life data during the fist year post treatment. The resulting population-based, African American cancer cohort will support studies addressing determinants of cancer prognosis and progression, survival, and outcomes of cancer-directed therapies. It will be one of the few cohorts to include a large minority community already actively engaged in cancer research, providing substantial data and biospecimens to facilitate studies aimed at understanding and addressing determinants of poor outcomes in this population. This work will be conducted in the context of a community uniquely engaged through our: 1) Community Network Program Center grant (U54) supporting a community based participatory research (CBPR) approach to addressing cancer disparities; 2) NCI-funded SEER cancer registry for population-based ascertainment of cancer cases in an economically depressed area with a large minority population; and 3) an NCI-designated Comprehensive Cancer Center with a strong transdisciplinary research program in cancer health disparities.

 描述（通过应用程序证明）：尽管在早期发现和治疗方面取得了进展，y癌症的癌症率更高，但被诊断出患有晚期疾病，并且比其他癌症进展，复发，死亡率和生命更高。癌症幸存者没有很好地研究生物，环境，社交因素。在家庭支持和经济负担方面发展研究的一部分的护理人员。 Rocs）kretiever。 对于50％疾病的结局基于人群的非裔美国人癌症队列将支持针对癌症预后和疾病的决定因素，生存和癌症指导疗法的结果，从而为旨在使贫困人口决定因素的研究提供了实质性的数据和生物测量。人口。中心具有强大的癌症健康差异的跨学科研究预言计划。