FUNCTIONAL CONNECTIVITY IN PATIENTS WITH CHRONIC NEUROPATHIC PAIN

慢性神经病理性疼痛患者的功能连接

• 批准号: 8362903
• 负责人: SEAN C MACKEY
• 金额: $ 1.3万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362903
• 关键词: Annual Reports; Attention; Behavioral; Chronic; Cognitive; Cognitive Therapy; Functional Magnetic Resonance Imaging; Funding; Grant; Imaging Techniques; Limb structure; Magnetic Resonance; Magnetic Resonance Imaging; National Center for Research Resources; Neuropathy; Pain; Pain Clinics; Patients; Principal Investigator; Reading; Research; Research Infrastructure; Resources; Rest; Scanning; Source; Technology; Time; Training; United States National Institutes of Health; Visit; abstracting; chronic pain; cost; distraction; relating to nervous system

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Cognitive behavioral therapy has long been used as a strategy for modulating chronic pain. Functional connectivity is an imaging technique to examine the strength of timecourse covariance of two neural entities. To better understand connectivity in the supraspinal modulation of pain, we looked at functional connectivity of the "pain matrix" as chronic pain patients modulated pain intensity with cognitive behavioral therapy. Five patients with chronic NP in a limb were instructed and trained on the cognitive behavioral strategies of attention, distraction, and positive and negative reappraisal. Each subject completed 4 scans using each strategy to modulate their pain, and a resting state scan. After performing resting state fMRI using a 3T MRI, the connectivity for each subject was calculated as the pair-wise correlation between average ROI time-courses. Subsequently, the average connectivity was determined by averaging across subjects. Finally, connectivity in different scans was compared using the Fisher's Z transformation. To read about other projects ongoing at the Lucas Center, please visit http://rsl.stanford.edu/ (Lucas Annual Report and ISMRM 2011 Abstracts)

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 认知行为疗法长期以来一直用作调节慢性疼痛的策略。功能连接是 成像技术，以检查两个神经实体的时代协方差的强度。更好地理解 疼痛上脊柱上的连通性，我们将“疼痛矩阵”的功能连通性视为慢性疼痛 患者通过认知行为疗法调节疼痛强度。 指示五名慢性NP患者在肢体中的认知行为行为策略，并训练 分心，正面和负面重新评估。每个受试者都使用每种策略完成了4次扫描，以调制其 疼痛和休息状态扫描。使用3T MRI执行静止状态fMRI后，每个受试者的连接性为 计算为平均ROI时间表之间的成对相关性。随后，平均连通性是 通过平均跨受试者的平均确定。最后，使用Fisher的Z比较了不同扫描中的连通性 转型。 要了解卢卡斯中心正在进行的其他项目，请访问http://rsl.stanford.edu/（卢卡斯年度报告和 ISMRM 2011摘要）