Mentoring in Discovery and Validation of Clinical Chronic Pain Biomarkers

指导临床慢性疼痛生物标志物的发现和验证

基本信息

批准号：
10429456
负责人：
SEAN C MACKEY
金额：
$ 32.4万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-24 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10429456
关键词：
Accelerometer Adult Affect American Anxiety Applications Grants Biological Biological Markers Chronic Clinical Computer Analysis Data Data Collection Data Set Demographic Factors Development Diagnostic Doctor of Medicine Doctor of Philosophy Enrollment Functional disorder Funding Future Goals Helping to End Addiction Long-term Immune Individual Infrastructure Interdisciplinary Study Journals Machine Learning Medicine Mentors Mentorship Mid-Career Clinical Scientist Award (K24)Musculoskeletal National Institute of Drug Abuse Neuraxis Outcome Pain Pain Research Pain interference Pain management Paper Parents Patients Phase Physicians Pilot Projects Preventive treatment Process Prognostic Marker Psychology Public Health Publications Publishing Recovery Refractory Research Research Personnel Research Project Grants Research Training Resources Risk Self Care Sensory Severities Sleep Social isolation Societies Structure Subgroup Substance Use Disorder Time Training Training Activity Training Programs United States National Institutes of Health Universities Validation Work Writing actigraphy analysis pipeline base biomarker signature candidate marker career career development chronic musculoskeletal pain chronic pain cohort conditioned pain modulation cost design diagnostic biomarker individualized medicine large datasets machine learning algorithm meetings microbiome multidisciplinary multiple omics neuroimaging new therapeutic target novel marker parent project patient oriented patient oriented research professor prognostic prognostic signature programs psychosocial research and development research study responsible research conduct risk stratification social treatment strategy treatment stratification

项目摘要

The primary goal of this K24 application is to allow Sean Mackey, M.D., Ph.D., to build and expand on his high- quality and intensive mentorship of early-career investigators in patient-oriented research (POR). Dr. Mackey is the Redlich Professor and Chief, Division of Pain Medicine at Stanford University. This K24 provides Dr. Mackey with the critical protected time for POR and mentoring that would otherwise be spent on administrative and clinical responsibilities. Dr. Mackey's mentoring plan for this K24 application builds on his currently funded HEAL project entitled: “Diagnostic and prognostic biomarkers for high-impact chronic pain: Development and validation”. Chronic pain represents a public health crisis that affects more than 100 million Americans and costs over $500 billion annually. An estimated 8% of US adults suffer from high-impact chronic pain, or pain associated with substantially restricted work, social, and self-care activities for six or more months. Subgroups of individuals respond entirely, do not change, or even worsen following pain management. Thus, robust and validated diagnostic and prognostic biomarkers are needed to identify those with high-impact chronic pain and determine the trajectory of outcome (i.e., recovery versus persistence), respectively. Therefore, our overall goal is to discover and validate diagnostic and prognostic biomarkers for musculoskeletal high-impact chronic pain. This goal will require comprehensive, multidimensional assessments with an integrated dataset and a sophisticated computational analysis pipeline to yield reliable and validated diagnostic and prognostic biomarkers. To this end, we have assembled an interdisciplinary research and clinical team to implement the HEAL initiative. Dr. Mackey's mentoring plan includes training his mentees in: 1) designing and implementing pain research studies; 2) preparing scientific papers and presentations; 3) writing successful grant applications; 4) the responsible conduct of research; and 5) successful navigation of the academic process to achieve scientific independence. This mentoring plan will be applied to the K grantees he mentors and those he oversees as the Program Director for his NIDA T32 “Interdisciplinary Research Training in Pain and Substance Use Disorders.” The mentees will engage in the training activites in three manners. The first is through direct involvement in the parent R61/R33 biomarker project via participation in aspects of the research project. The second is through seminars, journal clubs, meetings, and coursework that expands on our T32 Training Program focusing on this HEAL biomarker project. The third is through trainee-led pilot projects that leverage the parent project resources and associated multidisciplinary infrastructure. The funded HEAL project, combined with the additional mentoring time provided by the K24, will provide an exceptional POR training and mentoring platform for our large group of current and future K awardees, T32 fellows, and other trainees – and facilitate their transition into independent patient-oriented pain researchers.

该K24应用程序的主要目标是允许M.D.，Ph.D. M.D. Sean Mackey建立和扩展其高级早期研究人员面向患者研究（POR）的质量和密集思想。麦基博士是斯坦福大学的雷德里奇教授兼疼痛医学部长。该K24为博士提供了。麦基（Mackey）与POR和心理的关键时期有关，否则将花在行政上和临床责任。 Mackey博士针对此K24应用程序的心理计划建立在其目前资助的HEAL项目的基础上： “高影响力慢性疼痛的诊断和预后生物标志物：发育和验证”。慢性疼痛代表一种影响超过1亿美国人的公共卫生危机，成本超过5亿美元估计有8％的美国成年人患有高影响的慢性疼痛或与之相关的疼痛六个月或更长时间的工作，社会和自我保健活动实质上受到限制。个体的亚组完全反应，不要改变，甚至在疼痛管理之后担心。那是强大的和验证的需要诊断和预后生物标志物来识别那些患有高影响的慢性疼痛并确定的人结果的轨迹（即恢复与持久性）的轨迹。因此，我们的总体目标是发现并验证肌肉骨骼高影响慢性疼痛的诊断和预后生物标志物。这目标将需要全面的，多维的评估，并具有集成的数据集和复杂的计算分析管道以产生可靠且经过验证的诊断和预后生物标志物。对此最后，我们组建了一个跨学科研究和临床团队，以实施HEAL计划。麦基博士的心理计划包括培训他的月经：1）设计和实施疼痛研究研究； 2）准备科学论文和演讲； 3）编写成功的赠款申请； 4）负责任的研究； 5）成功导航学术过程以实现科学独立。该心理计划将适用于他指导的K授予者以及他在海外的人 NIDA T32的计划主管“疼痛和药物使用障碍的跨学科研究培训”。 Menies将以三种方式从事培训活动。首先是直接参与家长R61/R33生物标志物项目通过参与研究项目的各个方面。第二个是在我们的T32培训计划上扩展的SEMIAR，期刊俱乐部，会议和课程，重点是治愈生物标志物项目。第三个是通过实习生领导的飞行员项目来利用父母项目资源和相关的多学科基础架构。资助的治疗项目，结合 K24提供的额外心理时间将提供出色的POR培训和心理我们当前和未来的K获奖者，T32研究员和其他学员的平台，并促进他们过渡到独立的面向患者的疼痛研究人员。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

CHOIRBM: An R package for exploratory data analysis and interactive visualization of pain patient body map data.

DOI：
10.1371/journal.pcbi.1010496
发表时间：
2022-10
期刊：
PLoS computational biology
影响因子：
4.3
作者：
通讯作者：

The impact of COVID-19 on patients with chronic pain seeking care at a tertiary pain clinic.

DOI：
10.1038/s41598-022-10431-5
发表时间：
2022-04-19
期刊：
SCIENTIFIC REPORTS
影响因子：
4.6
作者：
Ziadni, Maisa S.;You, Dokyoung S.;Cramer, Eric M.;Anderson, Steven R.;Hettie, Gabrielle;Darnall, Beth D.;Mackey, Sean C.
通讯作者：
Mackey, Sean C.

Altered resting-state functional connectivity within corticostriatal and subcortical-striatal circuits in chronic pain.

DOI：
10.1038/s41598-022-16835-7
发表时间：
2022-07-25
期刊：
SCIENTIFIC REPORTS
影响因子：
4.6
作者：
Park, Su Hyoun;Baker, Anne K.;Krishna, Vinit;Mackey, Sean C.;Martucci, Katherine T.
通讯作者：
Martucci, Katherine T.

Utilizing a learning health system to capture real-world patient data: Application of the reliable change index to evaluate and improve the outcome of a pain rehabilitation program.

利用学习健康系统捕获真实世界的患者数据：应用可靠的变化指数来评估和改善疼痛康复计划的结果。