CHARACTERIZATION OF NEW METABOLITES FROM IN VIVO BIOTRANSFORMATION

体内生物转化新代谢物的表征

• 批准号: 8361399
• 负责人: FONG-FU HSU
• 金额: $ 4.79万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361399
• 关键词: Carcinogenesis Mechanism; Electrospray Ionization; Funding; Grant; Heterocyclic Amines; Ions; Mass Spectrum Analysis; Metabolic Biotransformation; Metabolic Pathway; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; biomedical resource; cost; in vivo; quinoline

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In studying the metabolic pathways underlying the mechanism of carcinogenesis of the heterocyclic amine of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), we recently found a new metabolite which gave an [M + H](+) ion of m/z 217 when subjected to electrospray ionization (ESI) in positive-ion mode.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 在研究2-氨基-3-甲基咪唑[4,5-f]喹啉（IQ）杂环胺致癌机制的代谢途径时，我们最近发现了一种新的代谢物，其具有[M + H](+ ) 在正离子模式下进行电喷雾电离 (ESI) 时 m/z 217 的离子。