TULANE COBRE: TRANSGENIC & GENE-TARGETED ANIMAL CORE

TULANE COBRE：转基因

• 批准号: 8360254
• 负责人: Luis Gabriel Navar
• 金额: $ 15.49万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360254
• 关键词: Animals; Biology; Blood Pressure; Cardiovascular Diseases; Cardiovascular system; Centers of Research Excellence; Core Facility; Faculty; Functional disorder; Funding; Gene Targeting; Genetically Engineered Mouse; Grant; Homeostasis; Hypertension; Maintenance; Methods; Molecular; Mus; National Center for Research Resources; Principal Investigator; Rat Strains; Renal Hypertension; Research; Research Infrastructure; Research Personnel; Resources; Source; Transgenic Organisms; United States National Institutes of Health; blood pressure regulation; cost; mouse model; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION: The transgenic and gene-targeted Animal Core Facility serves as a valuable resource for the maintenance and study of genetically engineered mouse and the rat strains that will contribute to the understanding of the pathophysiology of hypertension and the molecular mechanisms regulating blood pressure and cardiovascular disease states. This facility provides investigators access to unique resources and standardized methods to characterize transgenic and gene-targeted mice. Overall, the animal core provides access to unique state-of-the-art standardized methods to further characterize the novel transgenic and gene-targeted mouse models to study the blood pressure regulation and cardiovascular homeostasis. The core helps support project from junior faculty investigators as well as several of the senior faculty.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 描述： 转基因和基因靶向动物核心设施是维持和研究基因工程小鼠和大鼠品系的宝贵资源，这将有助于了解高血压的病理生理学以及调节血压和心血管疾病状态的分子机制。该设施为研究人员提供了独特的资源和标准化方法来表征转基因和基因靶向小鼠。总体而言，动物核心提供了独特的最先进的标准化方法，以进一步表征新型转基因和基因靶向小鼠模型，以研究血压调节和心血管稳态。该核心有助于支持初级教师研究人员以及几位高级教师的项目。