Translational Research in Hypertension and Renal Biology

高血压和肾脏生物学的转化研究

基本信息

批准号：
9113033
负责人：
Luis Gabriel Navar
金额：
$ 103.29万
依托单位：
TULANE UNIVERSITY OF LOUISIANA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-01 至 2019-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9113033
关键词：
Achievement Affect Area Award Basic Science Biology Biomedical Research Cardiovascular Diseases Cardiovascular system Cause of Death Centers of Research Excellence Cessation of life Clinical Investigator Clinical Research Core Facility Country Development Disease Environment Equipment Faculty Foundations Funding Goals Grant Health Sciences Hormonal Hypertension Injury Interdisciplinary Study Kidney Kidney Diseases Lead Link Louisiana Medical Students Mentors Mus Outcome Phase Phenotype Pilot Projects Population Sciences Positioning Attribute Postdoctoral Fellow Renal function Research Research Activity Research Infrastructure Research Personnel Research Project Grants Research Support Resources Scientist Training Transgenic Animals Translational Research United States United States National Institutes of Health Universities disability experience graduate student kidney vascular structure member mid-career faculty molecular imaging multidisciplinary professor success summer research

项目摘要

Because hypertension and associated kidney & cardiovascular diseases are highly prevalent in Louisiana, Tulane Health Sciences Center established a Hypertension and Renal Center of Excellence, which has developed rapidly as a consequence of the substantial support received by the COBRE award. COBRE Phases I and II provided support for 16 junior faculty members, of which 7 received NIH research funding, 19 postdoctoral fellows, 12 graduate students, and 29 medical students. In addition, the research infrastructure was markedly enhanced by the Molecular, Imaging, and Analytical Core, with state-of-the art facilities, and Transgenic Animal Core serving members of the Hypertension and Renal Center. For Phase III, the long-term goals are to provide an enriched environment to all investigators so that they can maintain nationally competitive status and to augment and strengthen the biomedical research capacity and infrastructure for Tulane investigators in hypertension, renal and cardiovascular disease. Our long term goals will be achieved through the following aims: 1) To provide support for maintaining the COBRE research CORES developed during Phases I and II that are essential for continuing the center's basic, clinical, and translational research. 2) To enhance the research infrastructure at Tulane Health Sciences Center in the multidisciplinary area of hypertension, renal and vascular biology thus maintaining and increasing national competitiveness for NIH and other federal grants by our faculty investigators. 3) To encourage and facilitate collaborative interactions between basic science investigators and clinical translational scientists in hypertension and related areas at Tulane Health Sciences Center. 4) To sustain a collaborative multidisciplinary research environment by providing support for research pilot projects and mentoring and training components. Collectively, the results will contribute to an increased understanding of the multiple interaction leading to the pathophysiological derangements that lead to hypertension and associated kidney and cardiovascular diseases. This COBRE will continue to increase the number of competitive scientists in a disease specific area of extremely high biomedical relevance in this region.

由于高血压及相关的肾脏和心血管疾病在路易斯安那州非常普遍，杜兰健康科学中心建立了高血压和肾脏卓越中心，该中心在 COBRE 奖的大力支持下发展迅速。 COBRE 第一期和第二期为 16 名初级教员提供了支持，其中 7 名获得了 NIH 研究经费，19 名博士后研究员，12 名研究生和 29 名医学生。此外，拥有最先进设施的分子、成像和分析核心以及为高血压和肾脏中心成员提供服务的转基因动物核心显着增强了研究基础设施。对于第三阶段，长期目标是为所有研究人员提供一个丰富的环境，以便他们能够保持全国竞争地位，并增强和加强杜兰大学研究人员在高血压、肾脏和心血管疾病方面的生物医学研究能力和基础设施。我们的长期目标将通过以下目标来实现： 1) 为维护第一阶段和第二阶段开发的 COBRE 研究核心提供支持，这对于继续中心的基础、临床和转化研究至关重要。 2) 加强杜兰健康科学中心在高血压、肾脏和血管生物学多学科领域的研究基础设施，从而保持和提高我们的教员研究人员在 NIH 和其他联邦资助方面的国家竞争力。 3) 鼓励和促进杜兰健康科学中心高血压及相关领域的基础科学研究人员和临床转化科学家之间的合作互动。 4) 通过为研究试点项目以及指导和培训提供支持，维持协作的多学科研究环境。总的来说，这些结果将有助于加深对导致高血压及相关肾脏和心血管疾病的病理生理紊乱的多重相互作用的理解。该 COBRE 将继续增加该地区生物医学相关性极高的疾病特定领域的有竞争力的科学家数量。