CHAGAS DISEASE: AN EMERGING FATAL DISEASE IN TEXAS

恰加斯病：德克萨斯州新出现的致命疾病

• 批准号: 8357671
• 负责人: JOHN L VANDEBERG
• 金额: $ 2.71万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357671
• 关键词: Affect; Animals; Blood; Brazil; Chagas Disease; Diagnostic; Diagnostic Procedure; Disease; Disease Progression; Funding; Genetic; Goals; Grant; Health; Heart; Heart Diseases; Housing; Human; Insecta; Latin America; Modeling; Monkeys; Morbidity - disease rate; National Center for Research Resources; Parasites; Pathology; Population; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Rural; Source; Texas; United States National Institutes of Health; Work; cost; human subject; mortality; nonhuman primate; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goals of this project are to generate tools and population resources for research on Chagas disease in human subjects and nonhuman primate models. Chagas disease affects 16-18 million people in Latin America, where it is the most prevalent cause of morbidity and mortality from heart disease. Chagas disease is an emerging disease in the US. Nonhuman primates housed in outdoor caging in southern US are naturally exposed to the insects that carry the disease-causing parasite and 2-10% of animals at the SNPRC are infected (percentage dependent on species). The grant provides bridge funding for an NIH grant on the genetics of Chagas disease in a human population in rural Brazil. It also funds the establishment of sensitive PCR diagnostic methods, the genetic characterization of the parasites endemic to Texas, the determination of feasibility of transporting infected blood from human subjects in Brazil to Texas for diagnostic work on the parasites, and assessment of disease progression by determining pathology in hearts from infected monkeys that die spontaneously or are euthanized for health reasons.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 该项目的目标是为人类受试者和非人类灵长类动物模型研究恰加斯病提供工具和人口资源。 恰加斯病影响拉丁美洲的 16-1800 万人，是导致心脏病发病和死亡的最普遍原因。 查加斯病是美国一种新出现的疾病。 美国南部户外笼养的非人类灵长类动物自然会接触携带致病寄生虫的昆虫，SNPRC 中 2-10% 的动物受到感染（百分比取决于物种）。 该赠款为美国国立卫生研究院 (NIH) 一项关于巴西农村人口恰加斯病遗传学的赠款提供过桥资金。 它还资助建立灵敏的 PCR 诊断方法、德克萨斯州特有寄生虫的遗传特征、确定将受感染的血液从巴西受试者运送到德克萨斯州进行寄生虫诊断工作的可行性，以及通过确定来评估疾病进展受感染猴子的心脏出现病理变化，这些猴子自然死亡或因健康原因被安乐死。